Restoring function in exhausted CD8 T cells during chronic viral infection (original) (raw)
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
Gordon Freeman, A. Rudensky
The Journal of experimental medicine, 2014
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Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection
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Proceedings of the National Academy of Sciences, 2011
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PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells
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The Journal of Immunology, 2015
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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Gordon Freeman
Nature Immunology, 2009
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Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults
Shubham Gupta
The Journal of …, 2011
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4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection
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The Journal of Immunology, 2011
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Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection
Rafi Ahmed
Journal of Experimental Medicine, 2008
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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
Gordon Freeman
Proceedings of the National Academy of Sciences, 2010
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Role of PD-1 during effector CD8 T cell differentiation
Jeanne Cheung
Proceedings of the National Academy of Sciences of the United States of America, 2018
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Modulation of PD-L1 and CD8 Activity in Idiopathic and Infectious Chronic Inflammatory Conditions
Flavia Pichiorri
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry, 2016
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Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
Kirsten Dietze, Kathrin Gibbert
The Journal of Immunology, 2011
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Gordon Freeman, Quentin Eichbaum
Nature, 2006
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Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load
Silvia Calpe
Immunity, 2011
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PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
David Price
Journal of Experimental Medicine, 2006
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Faculty of 1000 evaluation for Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy
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F1000 - Post-publication peer review of the biomedical literature
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Dual Control of Antitumor CD8 T Cells through the Programmed Death-1/Programmed Death-Ligand 1 Pathway and Immunosuppressive CD4 T Cells: Regulation and Counterregulation
Amanda Cleaver
The Journal of Immunology, 2009
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Viral acute lower respiratory infections impair CD8+ T cells through PD-1
Pavlo Gilchuk
Journal of Clinical Investigation, 2012
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The Role of CD80/CD86 in Generation and Maintenance of Functional Virus-Specific CD8+ T Cells in Mice Infected with Lymphocytic Choriomeningitis Virus
Jan Christensen
The Journal of Immunology, 2010
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Chronic Lymphocytic Choriomeningitis Virus Infection Actively Down-Regulates CD4 T Cell Responses Directed against a Broad Range of Epitopes1
Carla Oseroff
2000
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Chronic Lymphocytic Choriomeningitis Virus Infection Actively Down-Regulates CD4+ T Cell Responses Directed against a Broad Range of Epitopes
Edith Janssen
The Journal of Immunology, 2007
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The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection
Jonathan Chen
Immunity, 2014
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Dynamics of CD8+ T Cell Responses during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection
Rob J de Boer
The Journal of Immunology, 2007
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CD160-Associated CD8 T-Cell Functional Impairment Is Independent of PD-1 Expression
Denis Comte, Matthieu Perreau
PLoS Pathogens, 2014
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Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection
Friederike Berberich-siebelt
Immunity, 2017
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Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
Paul David
PLOS Pathogens, 2020
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Elevated Expression Levels of Inhibitory Receptor Programmed Death 1 on Simian Immunodeficiency Virus-Specific CD8 T Cells during Chronic Infection but Not after Vaccination
Gordon Freeman
Journal of Virology, 2007
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CD4+T-cell inhibitory ligands: a tool for characterizing dysfunctional CD4+T cells during chronic infection
Ryan Henderson
Immunology, 2013
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Human CD8+ and CD4+ T Cell Memory to Lymphocytic Choriomeningitis Virus Infection
Eddie James
Journal of Virology, 2011
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Independent Regulation of Lymphocytic Choriomeningitis Virus-Specific T Cell Memory Pools: Relative Stability of CD4 Memory Under Conditions of CD8 Memory T Cell Loss
Liisa Kaarina Selin
The Journal of Immunology, 2001
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