Association of Vitamin D Level with Fasting Plasma Glucose in Type 2 Diabetic Patients (original) (raw)
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Association Of Vitamin D Status And Diabetes Mellitus
2012
To evaluate the association of 25-hydroxyvitamin D3 (25OHD)inadequacyand hyperglycaemia in a Pakistani adult population.Study Design:Case control studyPlace & Period of Study:Department of Pathology, PNS SHIFA Hospital, Karachi; Aug 2011 to Nov 2011.Method and Material:Plasma Glucose levels were measured in 86 patients divided on the basis of their 25-hydroxyvitamin D3(25OHD)levels in three groups, normal (>31 ng/ml), insufficient (20-31ng/ml) and deficient (<20ng/ml). Vitamin D insufficiency (VDI)and Vitamin D Deficiency (VDD) are collectively called Vitamin D inadequacy. 25OHD was measured by electrochemiluminescenceusing Roche Elecsys® Systems while glucose was estimated by routine methods on Roche Hitachi® Autoanalyser.Results:.Vitamin D levels were inversely correlated with plasma glucose levels(r=-0.38;p<0.01) with an Odd Ratio of 3.59(95%confidence interval 1.29 to 8.70).Fasting plasma glucose was significantly higher in VDD patientsas compared to patients withnormal...
Asian Journal of Pharmaceutical and Clinical Research, 2017
Objective To investigate the existence of vitamin D deficiency (VDD) among type 2 diabetes, non-diabetes subjects and its effect on both glycemic and lipid profiles.MethodsA case control study was conducted on 200 subjects of both gender (100 type 2 diabetes and 100 non-diabetes individuals) aged 40 to 60 years. Fasting serum 25(OH) D levels, Fasting Blood Sugar (FBS), HbA1C, lipid profile including total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein TC/HDL and very low density lipoprotein were estimated. Atherogenic Index of Plasma (AIP) was calculated. Group comparisons were done by one way ANOVA followed by post hoc Tukey’s test and Student’s independent T test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. P < 0.05 was considered significant.Results The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficie...
Prevalence and severity of vitamin D deficiency in type 2 diabetic patients
International Journal of Advances in Medicine, 2020
Background: The current worldwide epidemic of diabetes mellitus is a serious health problem because of the high toll of vascular complications. Vitamin D deficiency as emerging epidemic have effect on pathophysiology of diabetes mellitus by various mechanisms, so we have taken up this study with aim to see effect of both high prevalent diseases on each other and to observe prevalence and pattern of vitamin D deficiency in diabetics.Methods: In this case-control study 70 type 2 diabetic patients were taken as cases and 70 healthy individuals as controls. All participants included in this study were subjected to complete history taking and clinical examination and routine laboratory Investigations were done for all participants. The data was analyse using appropriate statistical tests.Results: The prevalence of low vitamin D level (inclusive of insufficiency and deficiency) was 18.57% in healthy controls, while 84.29% in diabetic group. Mean level of vitamin D in cases was 25.73±7.27 ...
A Study on Vitamin D Levels in Patients with Type II Diabetes compared to Normal Subjects
2015
Vitamin D deficiency is highly prevalent in the world and in Asian countries including Iran. There is a great deal of evidence suggesting the relationship between serum Vitamin D level and prevalence of type II diabetes. The objective of this study was to assess the serum level of Vit D in diabetics and non-diabetics and to compare the results of the two groups. This descriptive epidemiological study was carried out on 79 participants including 40 diabetic patients and 39 healthy individuals. The participants were randomly selected from the participants of the Ahwaz Metabolic Syndrome project. The serum vitamin D level, FBS, PTH, and insulin level were measured in the participants. The insulin resistance (HOMA-IR index) was also calculated for all participants. In general, 97.1% of healthy participants and 88.1% of diabetics were diagnosed with vitamin D deficiency or inadequacy. No difference was observed between the levels of vitamin D in the two groups (P=0.23). There was a stati...
Association of serum Vitamin D level with Glycemic Status in Patients of Type 2 Diabetes Mellitus
Endocrinology & Metabolic Syndrome
Introduction: For development of Type 2 Diabetes mellitus, Vitamin D is thought to be a risk factor. Various studies have established the fact that Vitamin D replenishment improves glycemic status and insulin secretion in patients with Type 2 Diabetes mellitus with established hypovitaminosis D. This study was done to find out the degree of association between glycemic status and vitamin D levels in type 2 Diabetes Mellitus patients in a tertiary care center. Patient and methods: The study was done in the Department of Biochemistry, SCB Medical College, and Cuttack 48 patients of type 2 Diabetes Mellitus were taken as cases 42 healthy subjects were taken as controls. Biochemical parameters like FBS, PPBS, Urea, Creatinine, HbA1c, Lipid profile parameters were measured in both cases and controls. Results: The serum urea and creatinine levels were significantly elevated in complicated type 2 Diabetes mellitus patients as compared to healthy controls. Serum cholesterol, triglycerides, LDL Cholesterol levels also showed significant increase Vitamin D and FBS levels showed a significant negative correlation in cases and vitamin D levels were decreased in cases as compared to controls. Conclusion: As Vitamin D and FBS levels showed a significant negative correlation, and vitamin D levels were decreased in cases as compared to controls, so it can be proved that vitamin D can lead to good glycemic control and hypovitaminosis D can thereby lead to Type 2 Diabetes Mellitus.
Analysis of Vitamin D in Patients with Diabetes Mellitus Type 2
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
Diabetes Mellitus is a metabolic disease which is still a public health problem till now. World Health Organization (WHO) and International Diabetes Federation (IDF) predict an increase in the number of diabetics which become one of the global threats. Some evidences showed that vitamin D deficiency might influenced in pathogenesis of Type 2 Diabetes Mellitus that caused by insulin resistence and dysfunction of pancreatic beta cell. The objectives of this study is To analyze Vitamin D levels in Type 2 Diabetes Patients that consist of prediabetic group, controlled Type 2 Diabetes Mellitus Group, and uncontrolled Type 2 Diabetes Mellitus. The method used is a cross sectional study. During the study period, a total of 93 samples were obtained which met the study criteria. The sample consist of 33 prediabetic subjects, 30 controlled Type 2 DM subejcts, and 30 uncontrolled Type 2 DM. The study sample consist of 49(52,7%) men and 44(47,3%) women with minimum age 20 years and maximum 79 y...
Vitamin D status Association with newly diagnosed Type2 Diabetes Mellitus: A Case Control Study
Fayoum University Medical journal, 2018
Diabetes mellitus is one of the most common metabolic diseases in the world that can affect nearly every organ system in the body. Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. The aim of study; to investigate vitamin D level in type 2 diabetes and controls. A retrospective case control study with 47 newly diagnosed diabetic patients aged (35-70 years) and 54 controls matching age±5years and gender. Measuring HbA1c, FBG, assay serum 25(OH) D level were done for patients and/or controls. Results of current study, showed a more severe vitamin D deficiency in newly diagnosed diabetes than controls (46.8% vs.33.3%) and difference between vitamin D level in newly diagnosed diabetes compare to controls was not statistical significant (p=0.108). Conclusion: no statistical significant difference between newly diagnosed diabetes and controls concerning to vitamin D level.
Vitamin D Deficiency in Uncontrolled Obese Type II Diabetics
Zenodo (CERN European Organization for Nuclear Research), 2023
Vitamin D deficiency is epidemic in India.Due to industrial revolution and sedentary lifestyle less exposure to sunlight.Therefore Vit.D deficiency is very commonly observed in rural areas.Keeping this in mind this study is designed.This is a single centre study to know the Vit.D levels in diabetics and healthy individual's and also to understand the correlation between serum Vit D3 levels and index of glucose metabolism in patients of uncontrolled diabetes. Total 240 subjects were enrolled for this study. Comparison between 120 diabetic patients and 120 healthy controls were matched with age, sex and other details like BMI, waist/hip ratio, HbA1C, Vit.D were noted. Structured questionnaire prepared to collect information from selected subjects. The serum Vitamin-D3 i.e. [25(OH)D3] was detected by Maglumi 1000 (Snibe Diagnostic) technique. Statistical analysis done by IBM SPSS Software (latest version). As the significance is less than 0.05 (p<0.05, F = 4.432). It clearly reveals the fact that the model which was taken for study is statistically significant. Compared with the control group a higher rate of 25 (OH) D3 deficiency was found in uncontrolled Type 2DM subjects.Hence we conclude,higher the BMI lower the Vitamin D.
Vitamin D Deficiency and Type 2 Diabetes Mellitus
2014
Vitamin D has skeletal as well as non-skeletal effects including those on the endocrine system. Diabetes Mellitus, a leading cause of morbidity and mortality, has recently been linked to vitamin D status. It has been suggested that vitamin D deficiency is one of the modifiable risk factors for diabetes. We therefore designed this study to look at the relationship between vitamin D levels and diabetes control in type 2 South Asian diabetics from Pakistan. The objective of the study was to determine if correcting vitamin D deficiency improves diabetes control in type 2 diabetics. This analytical cross-sectional study, with prospective follow-up, included 200 subjects with type 2 diabetes (age range 27-76 years), who were deficient in vitamin D. 100 of these were treated with vitamin D and were assigned to the study group, while the rest did not receive treatment with vitamin D and so were placed in the control group. The subjects had their history taken and underwent clinical examinat...
Vitamin D deficiency and its relationship with Type II Diabetes Mellitus (Atena Editora)
Vitamin D deficiency and its relationship with Type II Diabetes Mellitus (Atena Editora), 2023
Hypovitaminosis D exceeds 50% of the Brazilian population, causing major implications for public health in the country. Low vitamin D levels are associated with worse glycemic control. Therefore, the aim of this study is to review the literature on the effect of vitamin D on glycemic control. It has been observed that a low concentration of vitamin D is associated with a decrease in both production and sensitivity to insulin. In patients with type II diabetes, there is a high prevalence of hypovitaminosis D. In this sense, studies with diabetics who underwent vitamin D supplementation still show contradictory data on the effectiveness of supplementation in glycemic control. Thus, it is of paramount importance to carry out research in the area for a reliable result that can cause a direct response in the population.