Prevalence of diabetes among tuberculosis patients (original) (raw)
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Prevalence of Diabetes among Tuberculosis Patients and Associated Risk Factors in Kathmandu Valley
SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS
Introduction: Diabetes among tuberculosis patients is a growing concern. The prevalence of diabetes among tuberculosis patients in Nepal is not known. The objective of this study was to determine the prevalence of diabetes among tuberculosis patients and to identify the associated risk factors. Methodology: A descriptive, cross-sectional study was conducted in Kathmandu valley of Nepal. Face to face interviews using structured questionnaire were conducted to collect socio-demographic and behavioral risk factors. A random blood sugar test was carried out using glucometer. Measurements on height, weight and waist circumference were taken to obtain the anthropometric information. Results: Out of 407 tuberculosis patients recruited in the study, 37 (9.1%) were found to have diabetes. Among them 28 (6.9%) were self reported cases of diabetes while 9 (2.2%) were found with random blood sugar level >200mg/dl. Tuberculosis patients aged 50 years and above (OR 7.5; 95% CI 2.72-20.66), ever tobacco users (OR 3.5; 95% CI 1.19-10.74), high income status (OR 5.2; 95% CI 1.59-17.26) and self history of high blood pressure (OR 20.0; 95% CI 5.07-79.50) were found significantly associated with diabetes. Conclusion: Overall, the prevalence of diabetes among tuberculosis patients was 9.1%. Older age, tobacco use, high income status and history of high blood pressure were identified as associated risk factors.
BMC Public Health
Background WHO addresses the infectious disease like Tuberculosis, and non- communicable disease like Diabetes among the top 10 causes of death worldwide, which collectively leads to increasing mortality and premature death especially in developing countries. Hence, the present study aims to assess the prevalence of diabetes and its associated risk factors among the tuberculosis patient of Morang, Eastern Nepal. Methods A cross-sectional study was carried out among the 320 respondents undergoing tuberculosis treatment of Morang district. Respondents from eight randomly selected DOTS centers were selected purposively. The Fasting Blood Sugar and 2-h Post-Prandial Blood Sugar were assessed in the laboratory of respective DOTS center by the glucose oxidase method. An interview for socio-demographic and other variables was conducted using a pretested semi-structured questionnaire based on WHO-STEP Instrument for chronic disease and excerpt from DASS-21 was used for the variable stress. ...
Kathmandu University Medical Journal, 2021
Background Since prehistoric time to the earlier 20th century, diabetes was accounted as comorbidity among tuberculosis patients, which is reducing the treatment efficiency. Objective To investigate the prevalence and determinants of type 2 diabetes mellitus among tuberculosis patients in central development region of Nepal. Method An analytical cross-sectional study was conducted by using structured questionnaire. Face to face interview as well as reviewing of the medical records of the tuberculosis cases has been performed during September 2018-February 2019. The systematic random sampling was applied to select 306 tuberculosis cases. Then the respondents were examined for blood glucose level as well as Glycated haemoglobin (HbA1c) level to identify TB with Diabetes Mellitus. The proportion of respondents with fasting blood glucose level ≥ 126 mg/dl or a random blood glucose ≥ 200 mg/dl was considered as Tuberculosis with Diabetes Mellitus cases. Similarly, haemoglobin A1C ≥ 7% was accessed as amplified risk for tuberculosis. Multiple logistic regression was performed to analyse the factors associated with Tuberculosis with Diabetes Mellitus by using STATA. P value < 0.05 was taken as statistically significant. Result A total of 306 tuberculosis patients were included in the study. The mean ± standard deviation of age of participants was 36.82±15.94 years. The proportion of male slightly exceeded than that of female with a ratio of 1.73:1. The prevalence of TBDM was 17.32% (95% CI: 13.05-21.58) of all diagnosed tuberculosis cases. Our multivariable analysis identified the factors those were associated with TBDM were age ≥ 45 years (adj.OR=3.97, 95% CI 1.81-8.71, p value 0.001), patients residing in the urban areas (adj.OR=9.75, 95% CI 1.99-47.6, p value 0.005), had Body Mass Index (BMI) <18.5 Kg/m 2 (adj.OR=3.20, 95% CI 1.58-6.51, p value 0.001), had diastolic blood pressure ≥ 80 mmHg (adj.OR=2.34, 95% CI 1.17-4.66, p value 0.015) and patients who were treated with Cat II and Cat III tuberculosis treatment regimens (adj.OR=2.65, 95% CI 1.22-5.73, p value 0.013). Conclusion The prevalence of type 2 diabetes mellitus among tuberculosis patients was higher than prevalence of diabetes in general population of Nepal and it was higher among male, urban residents, patients with low BMI and the older aged tuberculosis patients.
PLoS ONE, 2012
Background: Diabetes mellitus (DM) is recognised as an important risk factor to tuberculosis (TB). India has high TB burden, along with rising DM prevalence. There are inadequate data on prevalence of DM and pre-diabetes among TB cases in India. Aim was to determine diabetes prevalence among a cohort of TB cases registered under Revised National Tuberculosis Control Program in selected TB units in Tamil Nadu, India, and assess pattern of diabetes management amongst known cases. Methods: 827 among the eligible patients (n = 904) underwent HbA1c and anthropometric measurements. OGTT was done for patients without previous history of DM and diagnosis was based on WHO criteria. Details of current treatment regimen of TB and DM and DM complications, if any, were recorded. A pretested questionnaire was used to collect information on sociodemographics, habitual risk factors, and type of TB. Findings: DM prevalence was 25.3% (95% CI 22.6-28.5) and that of pre-diabetes 24.5% (95% CI 20.4-27.6). Risk factors associated with DM among TB patients were age (31-35, 36-40, 41-45, 46-50, .50 years vs ,30 years) [OR (95% CI) 6.75
Journal of family medicine and primary care
Tuberculosis (TB) and diabetes mellitus (DM) remains a worldwide global public health problem. About 95% of patients with TB live in the low and middle-income countries and more than 70% of patients with DM also live in the same countries, especially in South East Asia. Screening for diabetes in patients with TB will not only ensure early case detection but also better management of diabetes and will lead to better TB treatment outcome. This study aims to determine the prevalence and its associated factors of diabetes and prediabetes among diagnosed cases of TB patients registered under Revised National Tuberculosis Control Programme (RNTCP) in Bhopal city. The current study was a longitudinal follow-up study conducted among registered TB patients under RNTCP in all 5 TB units of Bhopal District. Participants were contacted and interview was conducted after obtaining consent using predesigned and pretested Performa during October 2013-September 2014. Continuous variable were summari...
Journal of Clinical and Diagnostic Research, 2019
Introduction: Tuberculosis (TB) ranks as the seventh leading cause of death in Nepal. Similarly, the prevalence of Diabetes Mellitus (DM) has also shown an increasing trend in the country and it has been observed that diabetes is strongly associated with falling treatment outcome of tuberculosis. Hence, the association of tuberculosis with Type 2 Diabetes Mellitus (T2DM) might be higher than the assumption and it needs more attention as well as appropriate measures to improve treatment outcomes of both diseases. Aim: To determine the risk factors of T2DM comorbidity among TB patients in the Central Development Region of Nepal. Materials and Methods: A case-control study was conducted by administration of structured questionnaire interview among all forms of pulmonary tuberculosis patients. A total of 102 tuberculosis patients with T2DM who met the inclusion criteria were considered as cases and 306 non-diabetes tuberculosis cases were considered as controls. The study was conducted among the patients attending the tuberculosis treatment centres of all 19 districts of central Nepal. The risk factors of diabetes among tuberculosis patients was estimated by using unconditional multiple logistic regression, adjusted odds ratio and their 95% CI were measured. Results: This present study found that the risk factors of type 2 DM comorbidity among tuberculosis patients were; age ≥45 years (adj. OR=8.00, 95% CI: 4.21-15.21, p-value <0.001), formal education (adj. OR=2.12, 95% CI: 1.08-4.15, p-value is 0.027), being underweight {Body Mass Index (BMI) <18.5 Kg/m 2 } (adj. OR=2.61, 95% CI: 1.49-4.59, p-value <0.001) and with diastolic blood pressure ≥80 (adj. OR=3.05, 95% CI: 1.72-5.43, p-value <0.001). In addition, tuberculosis patients who visited more than two health facilities for diagnosis and treatments (adj. OR=2.06, 95% CI: 1.10-3.85, p-value is 0.024) and had medium level of knowledge (60-80%) on tuberculosis and diabetes (adj. OR=2.19, 95% CI: 1.09-4.39, p-value is 0.027) were more prone to having tuberculosis and diabetes. Conclusion: Tuberculosis with diabetes is strongly associated with age, education, hypertension comorbidity as well as delayed diagnosis. Therefore, regular DM screening program as well as timely health monitoring system of tuberculosis patients will enhance the tuberculosis control program in reducing TB burden from delayed cure in Nepal.
Prevalence of diabetes mellitus among tuberculosis patients in Urban Puducherry
North American Journal of Medical Sciences, 2014
Background: Diabetes and Tuberculosis often present together and complicate each other at many levels. A collaborative framework for care and control of diabetes and tuberculosis developed by World Health Organisation and International Union against Tuberculosis and Lung Diseases emphasizes routine bi-directional screening for the two diseases. Aims: The study was to assess the prevalence of diabetes in tuberculosis patients currently on treatment. Materials and Methods: This facility-based cross-sectional study was undertaken in four randomly selected peripheral health institutions providing directly observed treatment short-course, treatment for tuberculosis patients. All cases of tuberculosis, more than 18 years of age were screened for diabetes. Risk factors like age, sex, family history of diabetes, alcohol, smoking and obesity were assessed. Results The prevalence of diabetes in tuberculosis patients was found to be 29% (known diabetics -20.7%, new Diabetes cases -8.3%). Diabetes was signifi cantly associated with older age, family history of diabetes, consumption of alcohol and sputum positivity. Conclusions: Screening patients with Tuberculosis for fasting blood sugar estimation will help in early detection of diabetes
Diabetes among tuberculosis patients increases the risk of tuberculosis treatment failure, death, and development of multidrug-resistant tuberculosis. Yet, there is no data is available in Bangladesh on the prevalence of diabetes among tuberculosis patients. The objective of the current study was to estimate prevalence and identify factors associated with tuberculosis-diabetes co-morbidity among TB patients enrolled in the Directly Observed Treatment, Short course program.
Collision of two epidemics: prevalence of diabetes in tuberculosis patients in urban Ludhiana
International Journal Of Community Medicine And Public Health
Background: Co-association between tuberculosis (TB) and diabetes has been observed for more than 2000 years. The burden of the both diabetes and tuberculosis is very high in India. Diabetes in TB patient decreases the success of anti-tubercular therapy and overall cure rates, which causes social and economic burden to country. The objective of the study was to find out the prevalence of diabetes mellitus in patients with tuberculosis under RNTCP treatment.Methods: This cross-sectional study was conducted in DOTS centers under Civil Hospital TU of Ludhiana, Punjab. 300 TB cases, above 18 years of age were included and screened for diabetes. Patients were interviewed regarding demographic profile and family history of diabetes. Height, weight, blood pressure, BMI and waist hip ratio were recorded.Results: The prevalence of diabetes in tuberculosis patients was found to be 21.3% (known diabetics- 6.3%, new diabetes cases- 15%). There was a statistically significant association of diab...