The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia (original) (raw)
Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia
Malay Mandal
Nature Medicine, 2007
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T Cell Leukemia-associa ted Human Notch/ Translocation-associated Notch Homologue Has IKB-like Activity and Physically Interacts with Nuclear Factor-KB Proteins in T Cells
Jorge Laborda
2000
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Notch and Ikaros: Not Only Converging Players in T Cell Leukemia
Diana Bellavia
Cell Cycle, 2007
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Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia
Maria Pia Felli
The EMBO Journal, 2006
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Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells
SUDHIR RAO
Cancer Research, 2009
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Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice
Alexis Dumortier
Molecular and Cellular Biology, 2006
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NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity
AndrÉ Baruchel
Blood, 2009
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Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
Jacques Ghysdael
Blood, 2010
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Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia
Julie Gorenstein
British Journal of Pharmacology, 2009
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A wide role for NOTCH1 signaling in acute leukemia
Raffaella Chiaramonte
Cancer Letters, 2005
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Jon Aster
Science, 2004
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Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond
Svenja Dannewitz
Cancers
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Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia
Antony Holmes
Proceedings of the National Academy of Sciences of the United States of America, 2017
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The Tumor Suppressor Gene hCDC4 Is Frequently Mutated in Human T-Cell Acute Lymphoblastic Leukemia with Functional Consequences for Notch Signaling
Martin Corcoran
Cancer Research, 2007
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Investigation of deregulated genes of Notch signaling pathway in human T cell acute lymphoblastic leukemia cell lines and clinical samples
mahdi paryan
Molecular Biology Reports, 2013
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NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome
Falastick Gamers
Frontiers in Immunology, 2014
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Notch signaling as a therapeutic target for acute lymphoblastic leukemia
Diana Bellavia
Expert opinion on therapeutic targets, 2018
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Notch Partners in the Long Journey of T-ALL Pathogenesis
Maria Toribio
International Journal of Molecular Sciences
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Growth Suppression of PreT Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling
Yunsun Nam
Molecular and Cellular Biology, 2003
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KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
hassan bjeije
Leukemia
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Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation
Freddy Radtke
Immunity, 2010
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Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model
Shigeo Masuda
Cancer Science, 2009
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PI3Kγ/δ and NOTCH1 cross-regulate pathways that define the T-cell acute lymphoblastic leukemia disease signature
Irina Lebedeva
Molecular cancer therapeutics, 2017
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In Silico Evidence of Signaling Pathways of Notch Mediated Networks in Leukemia
Kaiser Jamil, Kaiser Jamil
Computational and Structural Biotechnology Journal, 2012
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Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
Steven Chan
Blood, 2007
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Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia
Ute Koch
Blood, 2021
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Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation
J. Garcia-marco
Haematologica, 2014
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The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model
Maria Toribio
The Journal of clinical investigation, 2018
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