Desmoid Fibromatosis Mimicking Breast Cancer After Nipple-Sparing Mastectomy (original) (raw)
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Desmoid-type fibromatosis of the breast: A report of 2 cases
Oncology Letters, 2017
Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imaging examinations are not specific for fibromatosis and often imitate breast cancer. The current study presents 2 cases of women with breast fibromatosis, the first of which exhibited a locally advanced aggressive form of the disease, where breast surgery and en bloc resection of the underlying regions of the thoracic wall were required. In the second case, breast imaging examinations suggested an invasive breast tumor, probably carcinoma, infiltrating the muscles of the chest wall. An ultrasound-guided core needle biopsy revealed a low-grade myofibroblastic proliferation consistent with breast fibromatosis. The patient underwent a right quadrantectomy, with a partial resection of the underlying musculature. The patients remain disease-free at the time of writing. As involvement of the breast in patients with desmoid-like fibromatosis as rare, the present study reports 2 cases with clinical features and histological findings in order to improve and add to the knowledge of this disease.
World journal of surgical oncology, 2006
Fibromatosis or desmoid tumor of the breast is an extremely rare entity. While it lacks a metastatic potential, it can grow aggressively in a locally infiltrating pattern. The failure to recognize this as a finite entity within the breast can lead to local recurrence after incomplete excision. We report a case of a 70 year old patient with a remote history of invasive breast cancer (treated twelve years earlier by lumpectomy, axillary lymph node dissection, postoperative radiation therapy, and five years of tamoxifen) who developed fibromatosis within another quadrant of the same breast that clinically, mammographically, and sonographically mimicked that of the development of an ipsilateral metachronous breast cancer. After the initial diagnosis of fibromatosis was made on a minimally invasive ultrasound guided biopsy, it was successfully treated by wide local excision. After appropriate recognition, wide local excision can be the appropriate surgical management strategy for fibroma...
Desmoid Tumor of the Breast : a Case Report and Review of the Literature
The International Annals of Medicine, 2017
Fibromatosis or desmoid tumor (DT) is a rare entity, which constitutes 0.02% of all tumors. Desmoid tumor is frequently locally aggressive with frequent recurrence even if without metastatic potential. Breast is an unusual location of this entity, and only a few cases of breast desmoid tumors have been reported. We present a case of a desmoid tumor of the left breast in a 24-years-old woman, with a review of the literature.
Mammary Fibromatosis: Case Report and Review of the Literature
MOH Journal of Medical Case Reports, 2024
Breast fibromatosis (BF) is a rare, low-grade infiltrative spindle cell neoplasm from the breast connective tissue composed of fibroblasts and myofibroblasts. It is benign but has locally aggressive proliferation within the breast. It accounts for less than 0.2% of all breast tumors. Clinically, it often presents as a firm, painless, and immobile mass, which can be mistaken for malignancy due to its infiltrative growth pattern. In breast pathology, distinguishing between various conditions is crucial for effective diagnosis and appropriate treatment. Two such conditions that are often confused are BF and breast desmoid tumor (BDT). While they may share similarities, understanding their differences is essential for accurate medical management. BF arises from the fibrous connective tissue within the breast. However, BDT originates from deep fascial planes within the breast and exhibits an infiltrative growth pattern into surrounding tissues, analogous to soft tissue desmoids elsewhere in the body. It is generally accepted to consider BDT a more infiltrating form of BF. We present a case of a 38-year-old woman diagnosed with BF, and we review the relevant literature.
Toward a new strategy in desmoid of the breast?
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2015
To report initial results of observation as well as surgery in patients with desmoid tumors (DTs) of the breast, a rare tumor for which data are scarce. The initial approaches were categorized as either front-line loco-regional treatment [(surgery or radiotherapy group, SRG) n = 20] or initial observation [(no surgery/no radiotherapy group, NSRG) n = 11]. A total of 27 women and 4 men were assessed between 1992 and 2013 and included in this study. Patient characteristics were adequately balanced in the 2 groups. Fifteen patients (48.4%) had a past history of breast surgery in the previous 24 months. The median initial DT size on MRI was 50 mm. The median follow-up was 36 months. In the SRG, 8/20 patients (40%) experienced recurrence. The median time to recurrence was 29 months. During the study period, 6 patients in the SRG (30%) received a mastectomy at the time of diagnosis (n = 3) or at relapse (n = 3), 7 patients (35%) received a thoracic wall resection and 8 patients (40%) rece...
Unique Treatment Considerations for Chest Wall Desmoid Tumor Invading the Breast
Archives of Surgery and Clinical Case Reports, 2018
Desmoid Tumors (DT) are rare tumors, characterized by infiltrative growth and a tendency toward local recurrence but with an inability to metastasize. Although surgery is the primary treatment modality, there remains significant controversy amongst surgeons regarding the management of disease involving adjacent breast given the possibility for significant functional and aesthetic compromise [1]. This is a rare and interesting case of a young woman with a massive chest wall DT displacing the breast necessitating extensive chest wall resection and right partial mastectomy.
Breast fibromatosis: Making the case for primary vs secondary subtypes
The Breast Journal, 2019
Fibromatosis of the breast is a rare extra-abdominal desmoid tumor that typically lacks metastatic potential, but can be locally aggressive and lead to failure of loco-regional control if not adequately treated. Reports of fibromatosis of the breast are often discussed only in case reports and small case series. The consensus on treatment remains wide local excision; however, other therapies have been described. In discussion of an interesting case presentation of what we have defined as secondary breast fibromatosis, we reviewed relevant treatment modalities and discussed proper treatment for this patient. Our aims of this review of breast fibromatosis were fourfold. First, we present an interesting case report of a secondary breast fibromatosis with an aggressive surgical resection strategy. Second, we prompt a comprehensive discussion of fibromatosis with a review of the literature. Third, we offer the delineation between primary and secondary breast fibromatosis and determine if the behavior of the two is different. Finally, we present a case series. Overall, this comprehensive review highlights past and present recommendations in the treatment of this locally aggressive disease.