Breast fibromatosis: Making the case for primary vs secondary subtypes (original) (raw)
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Desmoid-type fibromatosis of the breast: A report of 2 cases
Oncology Letters, 2017
Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imaging examinations are not specific for fibromatosis and often imitate breast cancer. The current study presents 2 cases of women with breast fibromatosis, the first of which exhibited a locally advanced aggressive form of the disease, where breast surgery and en bloc resection of the underlying regions of the thoracic wall were required. In the second case, breast imaging examinations suggested an invasive breast tumor, probably carcinoma, infiltrating the muscles of the chest wall. An ultrasound-guided core needle biopsy revealed a low-grade myofibroblastic proliferation consistent with breast fibromatosis. The patient underwent a right quadrantectomy, with a partial resection of the underlying musculature. The patients remain disease-free at the time of writing. As involvement of the breast in patients with desmoid-like fibromatosis as rare, the present study reports 2 cases with clinical features and histological findings in order to improve and add to the knowledge of this disease.
Fibromatosis of the Breast: Case Report and Current Concepts in the Management of an Uncommon Lesion
The Breast Journal, 2006
Fibromatosis is an uncommon breast lesion that can mimic breast carcinoma in its clinical presentation. We present a case in which excisional biopsy was necessary to establish a diagnosis of fibromatosis. Clinical, diagnostic imaging, and pathologic features are discussed. Magnetic resonance imaging (MRI) has emerged as a tool for further characterization of breast lesions and as a screening modality in high-risk patient populations. Ours marks the second case in which dynamic MRI has been correlated with histologically confirmed primary mammary fibromatosis. Unlike the previous report, MRI in this case mimics breast carcinoma in its morphologic and pharmacokinetic features of enhancement. Wide local excision with clear margins remains the treatment of choice. Current data on radiotherapy and pharmacologic therapy for mammary fibromatosis are reviewed.
Fibromatosis of the breast: a 10-year multi-institutional experience and review of the literature
Breast Cancer, 2020
Background Breast fibromatosis is a rare clinical entity, but poses significant diagnostic and therapeutic challenges. In light of recent changes in management practices, the aim was to review our institutional experience of breast fibromatosis and provide a review of current available literature on such management. Methods A search of pathological databases within two tertiary institutions for all patients diagnosed with fibromatosis of the breast over a 10-year period (2007-2016) was performed. Clinicopathological characteristics and modes of treatment were recorded for each patient. Concurrently a comprehensive literature search was performed and studies relating to breast fibromatosis and its management were identified and reviewed. Results Sixteen patients were identified. Median age at diagnosis was 42 (range 21-70) and all patients were diagnosed with core biopsy. The most useful imaging modality in diagnosis was ultrasonography and magnetic resonance imaging. 13/16 were treated surgically whilst 3/16 were treated using a watch-and-wait approach. 6/13 (46%) required re-excision of margins and 2/13 (15%) had recurrence after surgery. On review of the literature, there is no dedicated guideline in place for the management of breast fibromatosis. Currently a 'watch and wait' approach is favoured over surgical intervention due to high levels of recurrence and associated surgical morbidity. All cases should be discussed at a sarcoma multidisciplinary team meeting and tyrosine kinase inhibitors should be considered in advanced cases. Conclusions Breast fibromatosis is rare but affects young patients. Active surveillance is now favoured over surgical resection due to high recurrence rates and extensive morbidity. Dedicated guidelines are required to ensure best outcomes.
Mammary Fibromatosis: Case Report and Review of the Literature
MOH Journal of Medical Case Reports, 2024
Breast fibromatosis (BF) is a rare, low-grade infiltrative spindle cell neoplasm from the breast connective tissue composed of fibroblasts and myofibroblasts. It is benign but has locally aggressive proliferation within the breast. It accounts for less than 0.2% of all breast tumors. Clinically, it often presents as a firm, painless, and immobile mass, which can be mistaken for malignancy due to its infiltrative growth pattern. In breast pathology, distinguishing between various conditions is crucial for effective diagnosis and appropriate treatment. Two such conditions that are often confused are BF and breast desmoid tumor (BDT). While they may share similarities, understanding their differences is essential for accurate medical management. BF arises from the fibrous connective tissue within the breast. However, BDT originates from deep fascial planes within the breast and exhibits an infiltrative growth pattern into surrounding tissues, analogous to soft tissue desmoids elsewhere in the body. It is generally accepted to consider BDT a more infiltrating form of BF. We present a case of a 38-year-old woman diagnosed with BF, and we review the relevant literature.
Aggressive Fibromatosis of Breast: A Rare Case Report
Fibromatosis, a locally aggressive but non-metastasizing neoplastic proliferation of fibroblastic cells, commonly encountered in the abdominal wall and extra-abdominal sites but rarely occurs in the breast. Here we report a case of aggressive fibromatosis of breast, which presented as a palpable mass in the right breast of a 53-year-old female. The physical examination revealed a 12x10 cm sized ovoid mass in the right upper outer quadrant. Ultrasonogram demonstrated an 8x5 cm sized hypoechoic mass with peripheral increased vascularity on doppler imaging. Wide local excision was done and pathology revealed aggressive fibromatosis.
World journal of surgical oncology, 2006
Fibromatosis or desmoid tumor of the breast is an extremely rare entity. While it lacks a metastatic potential, it can grow aggressively in a locally infiltrating pattern. The failure to recognize this as a finite entity within the breast can lead to local recurrence after incomplete excision. We report a case of a 70 year old patient with a remote history of invasive breast cancer (treated twelve years earlier by lumpectomy, axillary lymph node dissection, postoperative radiation therapy, and five years of tamoxifen) who developed fibromatosis within another quadrant of the same breast that clinically, mammographically, and sonographically mimicked that of the development of an ipsilateral metachronous breast cancer. After the initial diagnosis of fibromatosis was made on a minimally invasive ultrasound guided biopsy, it was successfully treated by wide local excision. After appropriate recognition, wide local excision can be the appropriate surgical management strategy for fibroma...
Fibromatosis of the Breast: Report of a Case with Cytohistological Correlation
Archives of Breast Cancer, 2022
Background: Breast fibromatosis is a very rare, locally infiltrative lesion, without metastatic potential that arises from either stromal fibroblasts or myofibroblasts of the breast or from the pectoral fascia, extending into the breast, with its cytological and histological features only rarely being described. Case Presentation: A 58-year-old woman, with no past medical/surgical or family history, was diagnosed on regular mammographic and ultrasound examination with a nodular tumor density, in the upper inner part of her right breast. There were no calcifications or apparent lymph nodes in the right axilla. The woman underwent FNA and US-guided biopsy and final resection biopsy under hook marking. We reviewed the cytological findings of fibromatosis of the breast, as they presented in FNAC aspirates of a non-palpable mammographic finding and the histological findings in both preoperative core-needle biopsy and excision specimen. The final diagnosis was of fibromatosis of the breas...
Breast fibromatosis, an unusual breast disease
Journal of surgical case reports, 2017
Fibromatosis is a benign tumor that rarely affects the breast and is an unusual site for its occurrence. Whilst the definite etiology of breast fibromatosis is unclear, it may present itself following surgical trauma or silicone implant. Wide local excision with adequate safety margins is considered the standard of care. We review three cases of breast fibromatosis who were presented to and operated in the Oncology center, Mansoura universty (between April 2014 and August 2016). Two of these cases underwent wide local excision and primary closure of the defect whilst the other one was reshaped by mini latismuss dorsi flap.
Desmoid Fibromatosis Mimicking Breast Cancer After Nipple-Sparing Mastectomy
Turkiye Klinikleri Journal of Case Reports
ABS TRACT Desmoid fibromatosis is an uncommon fibroproliferative condition and classified as an intermediate tumor because of low metastatic potential and risk of mortality. In this article, we present a rare condition with desmoid fibromatosis mimicking breast cancer in a 52 years old patient after nipple-sparing mastectomy. A 52-year old multiparous patient referred to the outpatient clinic due to gradually growing mass on the outer quadrant of her right breast. A core needle biopsy was performed and invasive ductal carcinoma was revealed. We did therapeutic mastectomy to the right and contralateral prophylactic mastectomy to the left breast. After one-year follow-up period, the patient applied to our clinic because of a palpable mass on the inferior quadrant of her right breast and chest pain while breathing. Gross pathology results showed a 5.5x1x0.4 cm tumor. Microscopic identification of the lesion showed a nonencapsulated mass with fibrous, gray and white nodular parenchyma. The diagnosis was desmoid type fibromatosis. When desmoid tumor occurs in the chest wall, especially after conservative breast surgery operations, these tumors may resemble the recurrent breast cancer.