Takayasu arteritis in Turkey (original) (raw)
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Takayasu's arteritis in Turkey - clinical and angiographic features of 248 patients
Clinical and experimental rheumatology
Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement patterns and clinical manifestations. The objective of this study was to evaluate the demographic, clinical, angiographic and prognostic features of TA patients in Turkey. Clinical and angiographic findings of 248 TA patients (228 female, 27 male) followed at 15 Rheumatology Centers were prospectively evaluated according to a predefined protocol. The mean age was 40.1 years (30.2 years at the clinical onset). Clinical manifestations included constitutional symptoms in 66%, absent or diminished pulses in 88%, bruits in 77%, extremity pain in 69%, claudication in 48%, hypertension in 43% and cerebrovascular accidents (CVA) in 18% of the patients. Renal artery stenosis, aortic regurgitation and pulmonary hypertension were present in 26%, 33% and 12%...
Takayasu's arteritis: results of a university hospital of 45 patients in Turkey
International journal of …, 2004
Background: Takayasu's arteritis (TA) is a rare disease which appears to be most common in East Asia. However, the disease has been reported to be worldwide. The clinical features of the disease can show variations in different geographical areas. The aim of this study is to ...
Cureus, 2021
Takayasu's arteritis is a rare form of chronic inflammatory disorder involving large vessels, with an unclear etiology. Common early signs and symptoms are weakness, malaise, and fever. Takayasu's arteritis mainly involves the aorta and its branches as well as the subclavian and carotid arteries. While radiologic methods can identify diseased vessels, they can't tell the difference between active and chronic lesions. This study reviews the characteristics of Takayasu's arteritis to identify any possible changes in the prevalence of symptoms of the disease. We conducted a literature review of case reports on Takayasu arteritis from PubMed and Google Scholar. Variables of interest were age, gender, symptoms, blood pressure (BP) measurement, diminished pulses, and radiological findings. Data were transferred to an Excel spreadsheet (Microsoft Corporation, Redmond, WA), and mean, median, and standard deviation, frequencies, and proportions were calculated using R version 1.1.456 (RStudio: Integrated Development for R. RStudio, PBC, Boston, MA). There were 43 cases, and females accounted for 88.3% of the presentations. The average age was 25 years, SD 12.5 years. Fever was the most frequent symptom (20.93%), followed by chest pain (13.95%), claudication (13.95%), and headache (13.95%). Less frequent complaints included shortness of breath (11.62%), weight loss (9.30%), syncope (6.98%), and night sweats (4.65%). On the right side, the average BP was 142/87 mmHg, and the left-sided finding averaged 115/72 mmHg. Decreased pulses were primarily seen in the radial artery with 15 cases. Radiological findings showed narrowing of the vessels in the following order: aorta (22), carotid (11), renal (10), subclavian (9), celiac (2), mesenteric (2), axillary (2), and tibial (1). The characteristics of Takayasu's arteritis were analyzed in this study. It identified several findings, ranging from fever symptoms to the signs of claudication, as well as the involvement of major vessels, such as the aorta and its branches, and a summary of radiological findings. This depicts the picture of Takayasu's arteritis and what physicians should expect when dealing with the disease.
Reumatismo, 2022
Takayasu arteritis (TA) is an extremely uncommon vasculitis that primarily affects the aorta and its branches. Due to the genetic and ethnicity effect, a diverse array of TA clinical manifestations has been reported worldwide. The purpose of the present study was to compare the clinicodemographic characteristics and pattern of vascular involvement of Iranian and Turkish TA patients. This study was a retrospective, cross-sectional investigation of 126 TA patients in Iran and Turkey. All of the variables analyzed were extracted from historical medical records. In 126 TA patients, the ratio of females to males was 8.6:1, and the average age at onset of disease was 30.5±11.1 years. Fatigue (49.2%) and a weak or absent pulse (79.4%) were the most prevalent symptoms and signs, respectively. The most prevalent angiographic classifications were types V and I in Iranian patients (41.09%) and type I in the Turkish population (47.7%) The left subclavian artery was the vessel most frequently affected by TA (66.6%). Our findings indicated that there were no significant differences between the two countries in terms of clinicodemographic characteristics or vascular involvement. Some clinical manifestations, such as claudication, were more prevalent in the Turkish population due to a higher incidence of occlusive lesions in the right subclavian artery.
TAKAYASU ARTERITIS: CLINICAL FEATURES AND MANAGEMENT: REPORT OF 272 CASES
Anz Journal of Surgery, 2005
Background: Takayasu's arteritis is a condition of unknown aetiology with an unpredictable natural history. Most of the literature available has originated from Asia, with a few contributions from Africa where the pattern of the disease may be different. This is a single institution's experience review. Methods: Data were obtained retrospectively from the angiographic and medical records of patients treated at Groote Schuur Hospital over the period 1952-2002. The criteria for inclusion were those proposed by the Aortitis Syndrome Research Committee of Japan and the American College of Rheumatology. Results: Two hundred and seventy-two patients were identified. The mean age at presentation was 25 years (range 14-66 years) and 75% were female. Only 8% were Caucasian. Hypertension was the most common presentation (77%) and was usually a consequence of renal artery stenosis or aortic coarctation. Cardiac failure was the most common problem. Cerebrovascular symptoms were recorded in 20%. Convincing evidence of tuberculosis was present in 20%. The entire aorta was involved in 70% of cases. Thirty per cent had aortic bifurcation involvement. Occlusions were noted in 93% and aneurysms in 46%. Vascular reconstruction was performed on 115 occasions in 99 patients, with an operative mortality of 4%. Cardiac failure was the usual cause of death. One hundred and six patients (39%) were followed for a minimum of 5 years. No further progression of disease was noted in 70 patients. Conclusion: The natural history and prognosis of Takayasu's arteritis still remain poorly defined.
Diagnosis and treatment of Takayasu arteritis in Turkey: A single center results
Turkish Journal of Thoracic and Cardiovascular Surgery, 2015
Takayasu's arteritis (TA) is a chronic, inflammatory disease that primarily affects large vessels such as the aorta and its main branches. The etiology of this disease is still not completely known, but various factors may have an impact on the pathophysology. [1,2] The most common finding of TA is granulomatous inflammation in the adventitia and medial wall of the involved vessels. In turn, this can lead to stenosis or occlusion in the lesions because of fibrosis followed by vessel dilatation via the deformation of ÖZ Amaç: Bu çalışmada hastanemizdeki Takayasu arteritli hastaların klinik, laboratuvar ve radyolojik özellikleri ile beraber cerrahi ve endovasküler girişim sonuçları incelendi. Ça lış mapla nı:Nisan 2002-Ocak 2014 tarihleri arasında Takayasu arteriti tanısı ile takip edilen 38 hastanın hastane kayıtları geriye dönük olarak incelendi. Kayıtlar Takayasu arteritinin klinik öyküsünü, eşlik eden hastalıkları, tanı sırasındaki laboratuvar bulgularını, anjiyografik bulguları ve tedavi şeklini içeriyordu. Bul gu lar: Kadın/erkek oranı 3.75:1 idi. Anjiyografik sınıflamaya göre; 11 hasta tip 1, üç hasta tip 2a, üç hasta tip 2b, dört hasta tip 3, altı hasta tip 4 ve 11 hasta tip 5 idi. Otuz sekiz hastanın 18'ine endovasküler veya cerrahi girişim uygulandı (8 cerrahi, 10 endovasküler girişim). Erken mortalite olmadı. So nuç: Hastalarımızın demografik ve anjiyografik özellikleri Japonya ve Akdeniz toplumları ile benzerdi. Endovasküler işlemlerin uzun dönem sonuçları ve restenoz yönetimi gelecekte karşılaşılabilecek zorluklardan olabilir. Baypas cerrahisi uzun dönem açıklık elde etmek için altın standart olmaya devam etmektedir. Endovasküler tedavi, cerrahi tedaviye uygun olmayan hastaların semptomlarında kısa süreli rahatlama sağlayabilir.
Objective: To analyse the clinical presentation, angiographic findings and outcome following intervention (endovascular and open surgical) in patients with Takayasu?s arteritis. Methods: This is a retrospective observational study of 28 patients who were diagnosed with Takayasu?s Arteritis and who presented to the department of Vascular Surgery, between January 2012 to January 2018. Their clinical presentation , angiographic findings, and outcome following intervention was analyzed. Results: 28 patients were analysed during study period. Among 28 patients, 25(89%) were female and 3(11%) were male. Average age of presentation was 29.34 years. Constitutional symptoms were reported in 13 patients(46.43%) and claudication in 11 patients(32%) .The commonest finding was hypertension in (57%) followed by absent pulses in 10 patients (42%). Major organ involvement was seen as cerebrovascular accident in 1 patient(7.14%) and cardiac findings included - chest pain 2(10.71%), aortic regurgitation 4(14.29%), mitral regurgitation or valve prolapse 2(7%) and pulmonary hypertension 2(7%) . According to the new angiographic classification,type I(32.14%) was encountered most frequently, followed by type III (25%), type IV (21.4%), type V (14%) and type IIb(7%) .The commonly involved vasculature was abdominal aorta(32%) , renal artery(25%) ,left subclavian (25%) followed by thoracic aorta(14%) and right subclavian (10%). Renal artery angioplasty was done in 5 patients and aneurysm repair was done in 1 patient with good outcome. Conclusion:-Takayasu?s Arteritis is a rare disease, with female predominance and varied clinical presentation. Angiography findings and clinical symptoms are integrated to decide management. Angiographic evaluation and percutaneous transluminal angioplasty with stenting is useful in selected cases; while majority of the patients are managed medically.
Takayasu's arteritis - a summary of current, clinically relevant knowledge of the disease
Journal of Education, Health and Sport
Takayasu's disease, also known as pulseless disease or aortic arch syndrome, is a rare inflammation of the aorta and its branches, and sometimes the pulmonary arteries, which, according to studies, occurs most frequently in people from the Far East and Asian countries. In addition, its incidence is significantly higher in women, and the mean age of affected patients is 45.4 years [1]. The first official clinical case report of the disease by Shimizu and Sano appeared in 1951, while the name of the disease was proposed by Cassamise and Okuda in 1954 to honour the first clinician, Mikito Takayasu, who as early as 1908 presented a case of a young female patient with characteristic fundus lesions associated with pulse disturbances [2].
Retrospective evaluation of 22 patients with Takayasu’s arteritis
Rheumatology International
Takayasu’s arteritis (TA) is a rare, idiopathic, inflammatory, granulomatous vasculitis that affects the aorta and its primary branches. Clinical features and the pattern of arterial involvement show differences in different regions of the world according to ethnic influences. Our aim in this retrospective study was to evaluate the demographic, clinic, laboratory, and angiographic findings of 22 patients with TA followed by our clinic and also compare our results with series from the literature. The hospital files of the 22 patients followed by our clinic between 1998 and 2009 were retrospectively evaluated. We also compared our results with the series from the literature that we were able to reach by US National Library of Medicine, National Institute of Health. Gender distribution, age at diagnosis, and type of aortic involvement were similar with the study from Turkey. Different clinical manifestations of Takayasu’s arteritis have been described in different ethnic groups. We also want to underline the coincidence of TA and other rheumatic diseases such as sarcoidosis, SLE, RA, and psoriatic arthritis, different from other published series.
A CASE OF TAKAYASU ARTERITIS IN ELDERLY MALE PATIENT
Takayasu arteritis is an inflammatory and stenotic disease of medium and large sized arteries characterized by strong predilection for the aortic arch and its branches. It is an uncommon disease with an estimated annual incidence rate of 1.2-2.6 cases per million. It is most prevalent in adolescent girls and young women and rarely seen in male. Here we present a case of 57 year old male, diagnosed to have takayasu arteritis involving the right subclavian artery. Keywords: takayasu arteritis, inflammatory, stenosis, aortic arch, right subclavian artery.