A Rare Case of Breast Cancer Metastasis to Oral Cavity Soft Tissue (original) (raw)
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Metastasis of Breast Cancer to the Mandibular Gingiva: Report of a Rare Case
Middle East Journal of Cancer, 2020
Metastatic tumors to the oral cavity are rare and account for only 1% of all oral cavity malignancies, and if occurs, it involves the jaws rather than the soft tissue. Diagnosis of a metastatic lesion in gingiva can be challenging owing to its rarity and atypical appearance. In this paper, we describe a rare case of breast cancer metastasis to the gingival soft tissue of mandible. A 68-year-old female referred to the department of oral and maxillofacial surgery with the chief complaint of a painful mass in the right buccal and lingual anterior region of the mandible with the mobility of the involved teeth. The patient also reported the history of a breast cancer dating back to eight years ago. Histopathologic findings and immunohistochemistry results supported a metatatic lesion. As a result, it is important to have a great clinical suspicion to diagnose such lesions in order to receive the most proper treatment to patients as soon as possible.
A Case Report on Mandibular Metastasis From a Breast Carcinoma
Cureus
Despite the rise in the number of cases of breast cancer in recent years, clinical diagnosis of a primary tumor in cases presenting with metastasis to the oral cavity poses a challenge in modern medicine because of its rare presentation. We report a case of breast cancer which presented as a painless swelling in the jaw. A 37-year-old multiparous woman consulted her dentist with complaints of toothache and swelling over the right cheek. On examination, she was diagnosed with dental caries and an orthopantomogram (OPG) was done to evaluate the swelling which revealed an area of rarefaction with an irregular margin on the right angle of the mandible. With suspicion of malignancy, the head, neck, oral and pharyngeal regions were thoroughly inspected and palpated. An ultrasonogram (USG) of the neck was done, which was normal and a core needle biopsy of the oral swelling was performed which showed metastatic carcinomatous deposits with pancytokeratin (PAN-CK) positivity, estrogen receptor (ER) positivity, and the Ki-67 value was 10% to 20% which was suggestive of breast carcinoma metastasis. Thereafter, the patient was referred for a surgeon's opinion. A breast examination was then done which revealed a lump in the right breast with a retracted nipple. A core needle biopsy of the lump revealed that it was ER and progesterone receptor (PR) positive and human epidermal growth factor receptor 2 (HER-2/neu) negative which confirmed the clinical diagnosis of breast cancer. Since the incidence of oral metastatic tumors is low, the likelihood of an early diagnosis of the distant primary tumor is reduced. Hence, all lesions of the oral cavity should be evaluated with due diligence considering the possibility of it being secondary metastases from distant tumors.
Breast carcinoma metastasis to the cheek: a case report
Journal of Medical Case Reports, 2022
Background Breast carcinoma is a common tumor in women, but it rarely metastasizes to the oral region. Furthermore, metastases to the oral region occur mainly to the maxillary and mandibular bone and rarely to soft tissue. Case presentation We describe a case of breast cancer metastasis to the buccal area. Examination of the right buccal mass of a 66-year-old Japanese woman was suggestive of breast cancer metastasis, and a breast lump was detected. Since receiving hormone-based treatment, the patient has survived more than 5 years and is now in remission. Conclusions An oral metastatic lesion may be the first sign of breast carcinoma; oral surgeons should be aware of this possibility.
Rare metastasis of breast cancer to mandible - a case report
Libri Oncologici Croatian Journal of Oncology, 2019
Breast cancer is the most common cancer in the female population. In Croatia, breast cancer makes up to 26% of all newly diagnosed cases of cancer in females. Breast cancer primarily metastasizes to bones, lungs, liver, brain and lymph nodes. We report a case of isolated metastasis of breast cancer to mandible in a 76-year-old female patient, who was diagnosed with cancer eleven years ago, which presented with diffi cult chewing, discrete pain, and continuing increase in tumor marker Ca15-3. Pathohistology of intraoral biopsy confi rmed a breast cancer metastasis. The patient received with palliative radiotherapy and hormone therapy. Every oncological patient complaining about the disorders in the mandibular area must be subject to thorough examination and metastasis should be included in the diff erential diagnosis. Metastatic lesion in the mandible is a sign of disseminated disease, and the treatment is most often palliative.
Medicina Oral Patología Oral y Cirugia Bucal
Background: Metastases in the oral cavity are rare and account for only 1 to 3% of all malignant lesions in this area. The primary location from which most metastases have been described in the oral cavity in adult patients include lungs, breasts, kidneys and colon. Material and Methods: A systematic search of the literature was carried out following the PRISMA statement in PubMed database. Clinical trials and case series published in the last 10 years [2010-2020] were eligible to be selected. The headings and keywords used in the searches were "cancer" AND "oral metastases", "incidence" AND "oral metastases", "oral metastases" AND "jaw bone", "oral metastases" AND "soft tissue". Results: For the study of the incidence of metastases in the oral cavity, 9 reports of clinical trials and 7 retrospective studies of case series have been included in this article. The primary locations from which more metastases have been described in the oral cavity are lungs (30.6% or 183 cases), breasts (22.2% or 133 cases), liver (15.5% or 93 cases), prostate (9 % or 54 cases), thyroid glands (8.1% or 49 cases), kidneys (7.3% or 44 cases), skin (2.3% or 14 cases), soft tissues (2% or 12 cases), colon (2% or 12 cases) and gastrointestinal (0.6% or 4 cases). These metastases have a predilection for hard tissues. The clinical presentation of these lesions varies from painless granulomatous lesions to lytic areas in the jaws. Conclusions: Although metastases in the oral cavity is an uncommon pathology, early diagnosis is needed so that in the event that it is the first manifestation, it allows the primary tumor to be diagnosed as soon as possible.
Metastasis from breast cancer presenting as an epulis in the upper gingiva
Journal of oral and maxillofacial pathology: …, 2009
Oral metastasis of breast cancer is less common than metastasis to other sites like the lung and liver. Breast cancer can metastasize to the oral cavity, with presentation like a benign oral lesion. We present an interesting case of breast cancer involving the gingiva with sparing of the underlying bone.
2022
Background: Buccal mucosa metastasis is rare in breast cancer patients. Case Presentation: A 50-year-old female breast cancer patient with invasive lobular carcinoma (ILC) in his eight years follow-up period presented with a swelling in the right eye. Head and neck MRI was showed soft tissue formation with dimensions of 59x31 mm was detected in the axial plane, extending from the level of the right infratemporal fossa to the right buccinator muscle and right maxillary sinus in front of the alveolar process. In the right periorbital region, there was a thickness increase of up to 1 cm in the thickest part of the globe, which was evident in the anterolateral. In addition, there was no bone destruction in the right infratemporal region in maxillofacial CT, and no additional organ metastasis was detected in PET-CT performed for systemic scanning. In the histopathological examination of the tissue, carcinoma infiltration was detected. Radiotherapy was applied to the right buccal and orbital region of the patient as 30 Gy in 12 fractions (2.5 Gy per fraction) with volumetric modulated arc therapy technique and then 15 Gy in 6 fractions (2.5 Gy per fraction) boost radiotherapy with the adaptive technique were applied. At the follow-up 2 months later, clinical response was observed in the patient, and significant regression of the lesion was observed in facial and orbital MRI. At the 15th month follow-up of the patient, clinical and radiological remission continues. All clinical complaints regressed. Conclusion: ILC is a subtype of breast cancer that is characterized by unusual metastasis. Therefore, during the follow-up of these patients, it is necessary to monitor both laboratory values and clinical complaints very carefully.
Oral and maxillofacial metastasis of male breast cancer: Report of a rare case and literature review
Oral surgery, oral medicine, oral pathology and oral radiology, 2018
Oral and maxillofacial metastatic tumors are uncommon, with the breast, prostate, lung, and kidney representing the most common primary sites. Less than 1% of all breast cancers occur in male patients, and to date, only 8 cases of metastatic breast adenocarcinoma to the oral and maxillofacial region in a male patient have been reported in the literature. An 88-year-old male with previous history of a successfully treated primary breast adenocarcinoma 12 years earlier was referred for evaluation of an oral swelling lasting 6 months. Intraoral examination revealed a 2-cm reddish, pedunculated nodule with a smooth surface located in the left retromolar region. Imaging revealed maxillary sinus involvement. The patient underwent incisional biopsy, and microscopic evaluation revealed invasive tumor islands compounded by malignant epithelial cells, sometimes exhibiting ductal arrangement, which were positive for the estrogen receptor and gross cystic disease fluid protein 15. The final dia...
From the breast to the upper jaw: A rare case of metastatic breast cancer
South Sudan Medical Journal, 2021
Breast cancer is the commonest malignancy in women globally. Metastases of advanced breast carcinoma to bones, lungs and liver are well known but spread to maxillary bone presenting as maxillary sinus and palatal swelling is rare. We present a case of advanced breast carcinoma in a female Nigerian with clinical, radiological and histopathological features of lung and right maxillary bone metastases. To the best of our knowledge, this is the first reported case of metastatic breast cancer to the lungs and maxilla in Nigeria. The debilitating sequelae of advanced untreated breast carcinoma in a resource limited setting with suboptimal comprehensive cancer care are highlighted.
Maxillofacial metastasis from breast cancer
Pan African Medical Journal, 2014
Metastatic tumors to paranasal sinuses are exclusively rare. In this paper, we report acase of breast carcinoma metastasizing to the right maxilla.