Tropical Journal of Natural Product Research (original) (raw)
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Jos Journal of Medicine, 2016
BACKGROUND: The role of herbal remedies and Non-Steroidal Anti-inflammatory Drugs in the development and progression of chronic kidney disease are yet to be fully studied in our environment despite their indiscriminate use. We set out to determine the prevalence and pattern of use of herbal remedies and NSAIDs and their relationship (if any) to chronic kidney disease. METHODS: Adults at a screening exercise in a village in Ondo State, Nigeria were studied. Their bio-data, history of herbal usage and NSAIDs, cigarette smoking, alcohol intake, diabetes mellitus and essential hypertension were obtained. Their blood pressure and anthropometry were measured. Urinalysis was conducted with Combi-Uriscreen®. Data was analysed using SPSS 20. RESULTS: One hundred and sixteen subjects were studied (M:F, 1:1.8). 51.7% were farmers. Their mean age was 42.5±14.7 years (range, 17-78 years). Their mean systolic and diastolic blood pressures were 125.2±20.4mmHg and 77.3±12.3mmHg respectively. Their mean body mass index was 26.2±6.0 kg/m2. Usage of herbs was found among 78.4% of subjects. 68.1% used NSAIDs, 11.2% had a history of cigarette smoking, 25.0% used alcohol, 50.0% had pre-hypertension, 28.0% had essential hypertension and 7.8% had diabetes mellitus. Undiagnosed hypertension was present in 24.1%. Proteinuria (ranging between 100mg/dl and 500mg/dl) was present in 12.5% of the subjects. Central obesity was present in 21.9% of the subjects. There was a significant association between proteinuria and use of herbs (p=0.023, chi square 5.188), use of NSAIDs (p=0.01, chi square 6.722), and pre-hypertension (p=0.039, chi square 4.261). CONCLUSION: The rates of use of herbal remedies and NSAIDs in the rural community are high. Our study suggests that they may cause significant proteinuria among users. There is therefore a need to conduct more high powered studies on this subject.
Awareness of chronic kidney disease: a community survey in Ado Ekiti, South Western Nigeri
2015
Chronic kidney disease (CKD) is a growing public health problem worldwide. Awareness about the disease has been documented to lead to early recognition, prompt treatment and halt progression to end-stage renal disease (ESRD). This study was carried out to determine the knowledge of CKD among inhabitants of Ado Ekiti, South Western Nigeria. Using a semi-structured questionnaire, the participants were interviewed during a public medical screening and scored on 13 items to determine their knowledge of anatomy, physiology, clinical features and treatment of CKD. The mean age of the participants was 36.04 ± 12.75years. A large proportion of the respondents 76.3% were able to identify correctly some functions of the kidney. The majority (78.4%) of the respondents have no idea about common symptoms associated with CKD. Few respondents knew that habitual use of NSAID and herbal concoction among others are potential causes of CKD. Overall, only 14.5% of the respondents had good knowledge abo...
Kidney International Supplements, 2013
Chronic kidney disease (CKD) is a global problem with increasing prevalence. End-stage renal disease (ESRD) accounts for 8% of all medical admissions and 42% of renal admissions in Nigeria. Screening for CKD facilitates early detection, evaluation, and treatment of CKD. There is a dearth of community-based data on the magnitude of CKD in Nigeria. This was an epidemiological study to define CKD and its risk factors in rural and semiurban communities in Southeast Nigeria. Obesity was defined as body mass index (BMI) 430 kg/m 2 . The metabolic syndrome was evaluated using the National Cholesterol Evaluation Programme Adult Treatment Panel III definition; hypertension was defined as systolic blood pressure (SBP) X140 mm Hg and/or diastolic blood pressure (DBP) X90 mm Hg. Diabetes mellitus (DM) was defined as fasting plasma glucose X7.0 mmol/l or 2-h plasma glucose X11.1 mmol/l. Proteinuria was regarded as significant if 1 þ and above, and hematuria was considered present if positive using urine strips. The glomerular filtration rate (GFR) was estimated using the CKD-EPI formula. A total of 2182 respondents aged 25-64 years were screened; 1941 with mean age of 43.7 ± 13.2 years were analyzed. Of this number, 26.1% had hypertension, 5.9% had DM, 10.4% had the metabolic syndrome, 14.9% were obese and 19% had proteinuria and/or hematuria. The prevalence of CKD was 11.4%. This study documented high prevalence of CKD and its risk factors. Routine screening of patients for risk factors for CKD at each contact with the doctor will help to identify early CKD patients who may benefit from preventive measures.
The Nigerian postgraduate medical journal, 2017
Chronic kidney disease (CKD) is defined as kidney damage or glomerular filtration rate (GFR) <60 ml/min/1.73 m 2 for more than 3 months with implications for health. [1] The incidence and prevalence of CKD have increased in the recent years in developed and developing nations and are consuming a huge proportion of health-care finances in developed countries while contributing significantly to morbidity, mortality and decreased life expectancy, particularly in developing countries. [2-5] There is a paucity of data on CKD from West Africa subregion. In Nigeria, lack of a national registry network and a coordinated national programme on kidney disease have restricted efforts toward the effective planning and control of renal diseases. In addition, it has also affected equitable allocation of resources. Studies aimed at quantifying the magnitude of CKD and determining the risk factors have been conducted in different parts of Nigeria with varying results. Some of these studies were hospital-based, and the definition of chronicity of the disease was based on the duration of suggestive symptoms and radiological evidence of chronic disease process thus assessing advanced stages of CKD in most instances. [6-8] Among the studies that were community-based, most of the studies did not repeat the laboratory investigations after 3 months to confirm CKD based on the generally accepted definition. [9-13] The objective of this study was to determine the prevalence
Néphrologie & Thérapeutique, 2019
Background Traditional medicine, which includes plants, has been increasingly used worldwide, especially in people with chronic conditions [1-4]. The prevalence of herbal medicine use in the previous 12 months of 2008 was 33.9% in Malaysia [3], 18.9% of the US adult population reported using natural herbs in past 12 months of 2002 [4], 10% in Australia used at least once herbal medicines in 1993 [5]. Patients with kidney disease have shown a higher prevalence of herbal medicine usage [3,7]. According to a study in northern Tanzania between December 2013 and June 2014, the prevalence of traditional medicine use in patients with chronic kidney disease (CKD) was 70.3% [8]. This use may be a risk factor of this pathology, knowing that about 35% of acute kidney injury cases are caused by traditional remedies in the developing world [9,10]. Additionally, it has been documented in many recent studies that several herbal medicine induce adverse renal effects ranging from worsening kidney function to renal failure [11-13].
PREVALENCE OF CHRONIC KIDNEY DISEASE IN A NIGERIAN FAMILY PRACTICE POPULATION
Background: Chronic kidney disease (CKD) is a global public health problem, with a greater burden and prohibitive cost of care particularly in developing countries. This study determined the prevalence of chronic kidney disease and identified its associated risk factors in patients attending the Family Practice Clinic, Wesley Guild Hospital, Ilesa, Nigeria.
Herbal medicines and chronic kidney disease
2010
ABSTRACT Alternative and indigenous systems of medicine are popular amongst the poorer sections of society in the developing world. Their use in the developed world has also increased in recent times. The source and composition of these medicines vary in different parts of the world, but herbs and other botanicals are central to these systems. Largely outside the ambit of regulatory control, herbal remedies are prepared by quasi-trained herbalists and not tested for safety.
Journal of Tropical Medicine, 2010
Background. The magnitude of the problem of chronic kidney disease (CKD) is enormous, and the prevalence keeps rising. To highlight the burden of CKD in developing countries, the authors looked at end-stage renal disease (ESRD) patients seen at the University of Nigeria Teaching Hospital (UNTH), Enugu, South-East Nigeria. Method. ESRD patients seen from 01/05/1990 to 31/12/2003 were recruited. Records from A&E Department, medical-out-patients, wards and dialysis unit were used. Results. A total of 1001 male versus 537 female patients were reviewed. About 593 male versus 315 female patients had haemodialysis. The mean age was 42.55 ± 15.43 years and 86.5% were <60 years. Primary renal disease could not be determined in 51.6% while hypertension and glomerulonephritis accounted for −17.2% and 14.6%, respectively. Death from renal causes constituted 22.03% of medical deaths. Conclusion. The prognosis for CKD patients in Nigeria is abysmal. Only few patients had renal-replacementtherapy (RRT). The prohibitive cost precludes many patients. This underscores the need for preventive measures to reduce the impact of CKD in the society.