Workshop of the latest development on the evaluation method of Environmental Fate & Bioaccumulation (original) (raw)

Towards the Definition of Specific Protection Goals for the Environmental Risk Assessment of Chemicals: A Perspective on Environmental Regulation in Europe

Integrated environmental assessment and management, 2016

This critical review examines the definition and implementation of environmental protection goals for chemicals in current European Union (EU) legislation, guidelines and international agreements to which EU countries are party. The European chemical industry is highly regulated and prospective environmental risk assessments (ERAs) are tailored for different classes of chemical, according to their specific hazards, use patterns and environmental exposure profiles. However, environmental protection goals are often highly generic, requiring the prevention of 'unacceptable' or 'adverse' impacts on 'biodiversity' and 'ecosystems' or the 'environment as a whole'. This review aims to highlight working examples, challenges, solutions and best practices for defining specific protection goals (SPGs), which are seen to be essential for refining and improving ERA. SPGs hinge on discerning acceptable versus unacceptable 'adverse' effects on the ke...

The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 150. Silicon carbide

2018

The main task of the Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals (NEG) is to produce criteria documents to be used by the regulatory authorities as the scientific basis for setting occupational exposure limits for chemical substances. For each document, NEG appoints one or several authors. An evaluation is made of all relevant published, peer-reviewed original literature found. The document aims at establishing dose-response/dose-effect relationships and defining a critical effect. No numerical values for occupational exposure limits are proposed. Whereas NEG adopts the document by consensus procedures, thereby granting the quality and conclusions, the authors are responsible for the factual content of the document.

Memorandum on the Use of in Silico Methods for Assessment of Chemical Hazard

2016

SCCS MEMORANDUM ON THE USE OF IN SILICO METHODS FOR ASSESSMENT OF CHEMICAL HAZARD SCCS The Committee shall provide Opinions on questions concerning health and safety risks (notably chemical, biological, mechanical and other physical risks) of non-food consumer products (for example cosmetic products and their ingredients, toys, textiles, clothing, personal care and household products such as detergents, etc.) and services (for example: tattooing, artificial sun tanning, etc.).

A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement

Environmental Health, 2023

The manufacture and production of industrial chemicals continues to increase, with hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact; all compounded by regulatory delays to the detriment of public health. Multiple authoritative bodies and scientific consensus groups have called for actions to prevent harmful exposures via improved policy approaches. We worked across multiple disciplines to develop consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures, which can be applied to current US policies governing industrial chemicals and environmental pollutants. This consensus identifies five principles and scientific recommendations for improving how agencies like the US Environmental Protection Agency (EPA) approach and conduct hazard and risk ^K en Zarker is deceased.

The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals

2013

The main task of the Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals (NEG) is to produce criteria documents to be used by the regulatory authorities as the scientific basis for setting occupational exposure limits for chemical substances. For each document, NEG appoints one or several authors. An evaluation is made of all relevant published, peer-reviewed original literature found. The document aims at establishing dose-response/dose-effect relationships and defining a critical effect. No numerical values for occupational exposure limits are proposed. Whereas NEG adopts the document by consensus procedures, thereby granting the quality and conclusions, the authors are responsible for the factual content of the document.

Towards a future regulatory framework for chemicals in the European Union - Chemicals 2.0

Regulatory Toxicology and Pharmacology, 2023

The body of EU chemicals legislation has evolved since the 1960s, producing the largest knowledge base on chemicals worldwide. Like any evolving system, however, it has become increasingly diverse and complex, resulting in inefficiencies and potential inconsistencies. In the light of the EU Chemicals Strategy for Sustainability, it is therefore timely and reasonable to consider how aspects of the system could be simplified and streamlined, without losing the hard-earned benefits to human health and the environment. In this commentary, we propose a conceptual framework that could be the basis of Chemicals 2.0-a future safety assessment and management approach that is based on the application of New Approach Methodologies (NAMs), mechanistic reasoning and cost-benefit considerations. Chemicals 2.0 is designed to be a more efficient and more effective approach for assessing chemicals, and to comply with the EU goal to completely replace animal testing, in line with Directive 2010/63/EU. We propose five design criteria for Chemicals 2.0 to define what the future system should achieve. The approach is centered on a classification matrix in which NAMs for toxicodynamics and toxicokinetics are used to classify chemicals according to their level of concern. An important principle is the need to ensure an equivalent, or higher, protection level.