The checkpoint for agonist selection precedes conventional selection in human thymus (original) (raw)

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

Zvi Grossman

Proceedings of the National Academy of Sciences, 1996

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T cell self-reactivity during thymic development dictates the timing of positive selection

Ellen Robey

eLife

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Author response: T cell self-reactivity during thymic development dictates the timing of positive selection

Ellen Robey

2021

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Positive selection of T cells, an in vitro view

Dzana Dervovic

Seminars in Immunology, 2010

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T‐cell selection in the thymus: a spatial and temporal perspective

Ellen Robey

Immunological Reviews, 2016

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Negative Selection in the Thymus Includes Semimature T Cells

J. Sprent

Journal of Experimental Medicine, 1997

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Signaling in thymic selection

Nicholas Gascoigne

Current Opinion in Immunology, 2011

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Thymocytes Positively Select Thymocytes in Human System

Jon Kim

Human Immunology, 1997

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Molecular signature of recent thymic selection events on effector and regulatory CD4 + T lymphocytes 1

Joost Van Meerwijk

2000

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Induction of thymocyte positive selection does not convey immediate resistance to negative selection

Judit Pongracz

Immunology, 2002

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Molecular Signature of Recent Thymic Selection Events on Effector and Regulatory CD4+ T Lymphocytes

Paola Romagnoli

The Journal of Immunology, 2005

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Signaling Life and Death in the Thymus: Timing Is Everything

Ed Palmer

Science, 2003

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Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus

Tom Taghon

Immunity, 2006

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Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR-repertoire 1

Joost Van Meerwijk

2006

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Agonist Ligands Expressed by Thymic Epithelium Enhance Positive Selection of Regulatory T Lymphocytes from Precursors with a Normally Diverse TCR Repertoire

Joost Van Meerwijk, Paola Romagnoli

The Journal of Immunology, 2006

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Extrathymic signals regulate the onset of T cell repertoire selection

HERMAN WALDMANN

European Journal of Immunology, 2000

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Thymocytes between the β-Selection and Positive Selection Checkpoints Are Nonresponsive to IL-7 as Assessed by STAT-5 Phosphorylation

Justin Van De Wiele

The Journal of Immunology, 2004

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Thymic selection

Ana Carrera

Current Opinion in Immunology, 1992

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Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

Stephen Jameson

Journal of Experimental Medicine, 1998

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Positive selection of a T-cell subpopulation in the thymus in which it develops

Kazuya Iwabuchi

Proceedings of the National Academy of Sciences, 1989

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The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

Willi Born

Cell, 1989

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The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

J. Sprent

Immunity, 1999

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Distinct Temporal Patterns of T Cell Receptor Signaling During Positive Versus Negative Selection in Situ

Ellen Robey

Science Signaling, 2013

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Temporal Predisposition to and T Cell Fates in the Thymus

Ana Cumano

The Journal of Immunology, 2012

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Alteration of T-cell Receptor Repertoires During Thymic T-cell Development

Takeshi Yoshioka

Scandinavian Journal of Immunology, 2006

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Thymic stromal cells and positive selection

Richard Boyd

APMIS, 2008

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How Many Thymocytes Audition for Selection?

Daniel Graf

Journal of Experimental Medicine, 1997

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

Georg Holländer

Nature, 2006

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Activation events during thymic selection

Polly Matzinger

Journal of Experimental Medicine, 1992

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Thymic selection of the human T cell receptor V beta repertoire in SCID- hu mice

Bart Vandekerckhove

Journal of Experimental Medicine, 1992

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Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor

Arkadiusz Miazek

The Journal of experimental medicine, 1995

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Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation

Gilles Marodon

European Journal of Immunology, 1994

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An Opposite Pattern of Selection of a Single T Cell Antigen Receptor in the Thymus and among Intraepithelial Lymphocytes

Wills Hetzel

2010

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The influence of the thymic environment on the CD4-versus-CD8 T lineage decision

Matilde Canelles

Nature Immunology, 2003

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T-cell receptor affinity in thymic development

Amy Moran

Immunology, 2012

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