Effect of Eight Weeks of Aerobic Training with Moqlenjan Supplementation on Lipid Profile and Glycemic Indices of Overweight Men (original) (raw)
Related papers
The Effect of Tongkat Ali Supplementation on Body Composition in Exercise-Trained Males and Females
Applied sciences, 2024
Background: It has been suggested that supplementation with Tongkat Ali may affect testosterone concentrations; moreover, whether this influences body composition is unclear. Thus, the purpose of this investigation was to determine if four weeks of Tongkat Ali (400 mg daily dose) supplementation affected body composition and salivary free testosterone concentrations. Methods: Thirty-three exercise-trained males (n = 19) and females (n = 14) volunteered for this investigation (mean ± standard deviation: age 33.1 ± 13.0 years; height 171.1 ± 11.3 cm; body mass 77.4 ± 16.8 kg; average total years of training 13.9 ± 13.2; average hours of resistance training/week 4.2 ± 2.5; average hours of aerobic exercise/week 3.4 ± 2.8; average hours of other exercise/week 1.1 ± 2.0). Research participants were pre-and post-tested for body composition (InBody 270), Profile of Mood States (POMS), handgrip strength, and sleep (Pittsburgh Sleep Quality Index [PSQI]). In a subset of the research participants, saliva samples were collected and analyzed for cortisol and free testosterone. The research participants consumed 400 mg of Tongkat Ali or a placebo (rice flour) daily for four weeks. Results: There were no between-group differences (p > 0.05) for body composition (delta score, mean ± SD: lean body mass kg-treatment -0.5 ± 1.9, placebo -0.4 ± 0.7; fat mass kg-treatment -0.5 ± 1.6, placebo 0.3 ± 1.0, % fat treatment -0.1 ± 1.4, placebo 0.5 ± 1.1). Moreover, there were no differences between groups for any additional assessments (e.g., handgrip strength, mood, sleep, and salivary free testosterone and cortisol). Conclusions: Four weeks of supplementation with Tongkat Ali in exercise-trained males and females does not affect body composition, mood, sleep, vigilant attention, handgrip strength, cortisol, and free testosterone.
International Journal of Pharmacy, 2017
Kutajarista (KTJ) is an Ayurvedic preparation used as a traditional medicine in the South Asian countries for the treatment of diarrhoea, dysentery and irritable bowel syndrome. The effect of chronic administration of KTJ on the serum lipid profile was studied in this experiment. After 28 days of chronic administration of the KTJ preparation to the male Sprague-Dawley rats at a dose of 40 ml/kg the following biochemical changes were noted. There was a statistically very highly significant (p=0.001) increase in serum LDL-C level whereas a significant increase was noted in case of total cholesterol (TC) level (p=0.013). A significant (p=0.039) decrease was noticed in HDL-C level but in case of Non-HDL-C level, a highly significant (p=0.002) increase was noticed. Besides, a statistically very highly significant (p=0.001) decrease was noted in case of serum triglyceride (TG) and VLDL-C level; thus leading to a statistically highly significant increase (p=0.004) in Cardiac Risk Ratio (CRR) (TC/HDL-C) and Atherogenic Coefficient (AC) ((TC-HDL-C)/HDL-C), a statistically very highly significant (p=0.001) increase in Castelli's Risk Index-II (CRI-II) (LDL-C/HDL-C) but a statistically very highly significant decrease (p=0.001) in case of Atherogenic Index of Plasma (AIP) ((log (TG/HDL-C)).
Clinical Safety of Selected Ayurvedic Formulations in Obesity and Dyslipidemia
Journal of research in ayurvedic sciences, 2017
Introduction: Obesity is a condition of abnormal or excessive fatness, and dyslipidemia is a condition with abnormal raised levels of any one or all lipids in the blood. Ayurveda compares signs and symptoms of obesity and dyslipidemia with the disease Sthaulya/Medoroga. Vyoshadi Guggulu and Haritaki Churna are the most commonly used medicines in the management of Sthaulya. However, the safety of these drugs was not evaluated until now through clinical trials. Objective: The objective of this study was to assess clinical safety of Vyoshadi Guggulu and Haritaki Churna in the management of obesity (Sthaulya) and dyslipidemia. Materials and methods: A prospective, open-label multicentric study was carried out at peripheral institutes of the Central Council for Research in Ayurvedic Sciences (CCRAS). Total 306 patients satisfying selection criteria were randomly selected from the outpatient department of respective centers and were administered Vyoshadi Guggulu (3 tablets of 500 mg) and Haritaki Churana (3 gm twice daily) in case of obesity, and Vyoshadi Guggulu (2 tablets of 500 mg thrice in a day) and Haritaki Churana (3 gm twice daily in cases of dyslipidemia) with lukewarm water for 12 weeks. So, the daily intake of the medicine was similar in all these cases. Hematological para
Iranian Journal of Pharmaceutical Research
Background: The prevalence of obesity has almost tripled since 1975, and obesity places a heavy economic burden on healthcare systems. There is a high tendency to use a variety of complementary medicine modalities for weight management among obese patients. Persian Medicine is an ancient medical school practiced for thousands of years in Iran. Found in reliable Iranian traditional resources, Komouni formulation (KF) is a compound medicine that can be effective in the treatment of obesity. It comprises black caraway (Bunium persicum Boiss.), anise (Pimpinella anisum L.), fennel (Foeniculum vulgare Miller), and ajwain (Trachyspemum ammi L.) Objectives: This study aimed to determine the effects of KF on anthropometric indices and metabolic parameters in overweight and obese women. Methods: This triple-blinded randomized controlled clinical trial was performed on 70 overweight or obese women aged 20 - 40 years, with a body mass index (BMI) of 25 - 34.9 kg/m2. The subjects were randomly ...
Kutajarista (KTJ) is an Ayurvedic preparation used as a traditional medicine in the South Asian countries for the treatment of diarrhoea, dysentery and irritable bowel syndrome. The effect of chronic administration of KTJ on the serum lipid profile was studied in this experiment. After 28 days of chronic administration of the KTJ preparation to the male Sprague-Dawley rats at a dose of 40 ml/kg the following biochemical changes were noted. There was a statistically very highly significant (p=0.001) increase in serum LDL-C level whereas a significant increase was noted in case of total cholesterol (TC) level (p=0.013). A significant (p=0.039) decrease was noticed in HDL-C level but in case of Non-HDL-C level, a highly significant (p=0.002) increase was noticed. Besides, a statistically very highly significant (p=0.001) decrease was noted in case of serum triglyceride (TG) and VLDL-C level; thus leading to a statistically highly significant increase (p=0.004) in Cardiac Risk Ratio (CRR) (TC/HDL-C) and Atherogenic Coefficient (AC) ((TC -HDL-C)/HDL-C), a statistically very highly significant (p=0.001) increase in Castelli’s Risk Index-II (CRI- II) (LDL-C/HDL-C) but a statistically very highly significant decrease (p=0.001) in case of Atherogenic Index of Plasma (AIP) ((log (TG/HDL-C)).
Agriculture and Biology Journal of North America, 2010
Ardhabilva Kvatha Curna (ADR) is a poly herbal Ayurvedic preparation that is traditionally used in Bangladesh for the treatment Malabandha (obstructed feces). The present study was undertaken to observe the effect of this formulation on lipid profile reveals that it possesses hypotriglyceridemic property. The change in the lipid profile both in the male and female rats was in the same trend except Very Low Density Lipoprotein. In the male rats there was a statistically significant decrease in the Triglycerides (p=0.001***). Similar trend was observed in case of total cholesterol (p=0.491), Very Low Density Lipoprotein (p=0.673) and Low Density Lipoprotein (p= 0.211) but these decrease was not statistically significant. There was statistically insignificant increase was observed incase of High Density Lipoprotein (p=0.784). In the female rats there was a statistically significant decrease in the Triglycerides (p=0.001***). In case of total cholesterol (p=0.381) High Density Lipoprotein (p= 0.714), Low Density Lipoprotein (p= 0.131), there was not remarkable change in comparison with control groups. In the female rats the amount of Very Low Density Lipoprotein was increased that was different from male rats.
BMC complementary medicine and therapies, 2024
Background Several studies showed the hypoglycemic and hypolipidemic effects of Satureja Khuzestanica (SK) in animal models. This study aimed to determine the effect of SK supplementation on glycemic and lipid outcomes of patients with type 2 diabetes mellitus (T2DM). Methods The study was designed as a double-blind, placebo-controlled, randomized clinical trial using block randomization. Seventy-eight T2DM patients were randomly assigned to intervention (n = 39) or placebo (n = 39) groups. They received SK or placebo in 500 mg capsules daily for 12 weeks. Anthropometric, blood pressure, liver enzymes, glycemic, and lipid outcomes were measured before and after the intervention. Results At baseline, there were no significant differences in age, sex, or glycated hemoglobin (HbA1c) levels between the groups. SK supplementation led to a significant decrease in FBS (-12.6 ± 20.7 mg/dl in the intervention group versus 3.5 ± 31.9 mg/dl; p = 0.007), HbA1c (-0.28 ± 0.45 in the intervention group versus 0.11 ± 0.54% in the placebo group; p = < 0.001), insulin (-1.65 ± 6.18 in the intervention group versus 2.09 ± 5.90 mIU/L in the placebo group; p = 0.03), total cholesterol (-14.6 ± 21.1 mg/dl in the intervention group versus 8.2 ± 30.9 mg/dl in the placebo group; p < 0.001), LDL-cholesterol (-4.6 ± 15.2 mg/dl in the intervention group versus 5.8 ± 14.6 mg/dl in placebo group; p < 0.001) levels, and significant increase in HDL-cholesterol (3.9 ± 4.9 mg/dl in the intervention group versus 0.9 ± 5.2 mg/dl in placebo group; p = 0.005). Conclusion Based on the study results, SK supplementation may improve glycemic indices and lipid profile of patients with T2DM. Our findings may provide novel complementary treatments without adverse effects for diabetes complications. These results need to be further confirmed in clinical trials. Registration : This trial has been registered in the Iranian Registry of Clinical Trials (IRCT ID: IRCT20190715044214N1, registration date: 21/02/2021).
Pathophysiology of Metabolic Syndrome – Its Management by Ayurvedic Formulation
Metabolic syndrome (Met S) is a disorder of energy and storage containing of risk factor for various complications such as Type 2 diabetes mellitus and cardio vascular disease. In Met S combined effect of atherogenic property, insulin resistance, hypertension and obesity occurs. Obesity significantly influences the onset of cardiovascular disorders particularly in the presence of type 2 diabetes mellitus giving rise to Met S. Various plant based remedies are known to treat metabolic syndrome by virtue of their antihyperlipidemic, antitumour, antioxidant, anorexia, anti-inflammatory and antihyperglycemic activities. Present study was designed to assess the effect of herbal test formulation of five plants viz., Dioscorea bulbifera, Termenalia chebula, Termenalia arjuna, Hippophae rhamnoids and Nardostachys jatamansi in hyperglycemic and hyperlipidemic (atherogenic property) albino Wistar rats. D. bulbifera (bulb), T. chebula (berries), T. arjuna (dried fruit pulp), N. jatamansi (rhizome) and H. rhamnoids (bulb) were collected, dried and powered. Distilled water and alcohol (60:40) was used to extract the active constituents present in the plant samples and were mixed in a definite proportion to make test formulation. Two studies were designed to assess the anti hyperglycemic and anti-atherogenic activity of the test formulation in high cafeteria and high cholesterol rich diet induced experimental rats respectively. In study I body weight, systolic blood pressure, total cholesterol, triglycerides , plasma insulin decreases significantly on the administration of ayurvedic formulation dose dependent with control group while in study II significantly reduction in LDL-c and increase in level of HDL –c giving treatment with conventional anti – obesity drug. Obesity is a multi factorial disorder and is a major risk factor for T2DM, hypercholesterolemia and ischemic heart disease. Present study revealed that the administration of test formulation in hyperglycemic and hyperlipidemic rat models mitigates the body weight, cholesterol, triglycerides, blood glucose, LDL-c, and HDL-c towards the normal values. The test formulation showed anti-hyperglycemic, insulin sensitivity enhancing, and anti atherogenic activity in hyperglycemic and hyperlipidemic induced rats. Keywords: Metabolic syndrome, Ayurvedic formulation, Hyperlipidemia, Hyperglycemia, lipid profile.
The Role of Mollucas Traditional Food on the Improvement of Risk Factors of Coronary Heart Disease
American Journal of Medical Sciences and Medicine, 2015
Background: More than 60% of the global burden of coronary heart disease occurs in developing countries and approximately 75% of cardiovascular disease can be attributed to conventional risk factors, most of which is modifiable. The Indonesia Diabetes-Obesity-Cardiovascular disease (DOCAR) Prevent Study has started from 2005 focusing on finding ways with local wisdom in preventing DOCAR. Purpose: The purpose of this study is to examine the association between the Mollucas Traditional Food (MTF) diet and the risk factors of CHD. Methods: The design of the study is cross sectional. All participants were only men, pure mollucas ethnic, age ranging from 40 to 60 years old. The participants were devided into two group; 73 were in Ambon city with Non-MTF diet and 73 in Taniwel Village, West Seram district with MTF diet. Data were collected through measurements of physical and laboratory parameters (Lipid profile, adiponectin, free fatty acid [FFA], oxLDL, hsCRP) and analysed using univariat, independent -sample T-test, linier regression and double linier regression methods. Results: The CHD risk factors in non-MTF compare to MTF diet group are: waist circumference are 93.35 ±9.57 and 78.84±7.8 cm respectively (p=0.000); adiponectin level are 5.53±2.83 ng/mL and 12.06 ± 4.64 ng/mL respectively (p=0.000); hs-CRP level are 4.52 ± 9.69 mg/L and 3.61 ± 6.37 mg/L respectively (p=0.507); FFA level are 0.43 ± 0.24 mM and 0.37 ±0.47 mM respectively (p=0.379); Ox-LDL level are 66.14 ± 31.11 ug/mL and 66.09 ± 27.55 ug/mL respectively (p=0.991). The correlation analisis revealed that food consumption i.e. non-MTF and MTF have significant impact on waist circumference (r=0,642, p=0.000) and adiponectin (r=0.649, p=0.000); but not with hsCRP (r=0.003; p-0.97), free fatty acids (r=0.073, p=0.379), as well as oxidized LDL (r=0.001, p=0.991). Conclusion: These results might indicate that Mollucas Traditional Food (MTF) provide better protective value than non-MTF through adiponectin level and body weight instead of inflammation (hsCRP) and lipid (FFA and oxLDL) mechanisms.
Current Nutrition & Food Science, 2020
Background: Hyperlipidemia is the major precursor of lipid-related diseases. Consumption of high fiber foods may decrease lipid profiles. The fiber content in tempeh gembus is three times higher than regular tempeh. Objective: This study was conducted to investigate the effect of tempeh gembus on lipid profiles in women with hyperlipidemia. Methods: This research used the quasi-experimental design with nonequivalent control group design. Subjects were 41 women with hyperlipidemia, classified into 3 groups: control group, treatment group 1 given 103 g/day tempeh gembus, and treatment group 2 given 206 g/day tempeh gembus for 14 days. All of the groups received nutrition education. Total cholesterol and HDL-C were determined by CHOD-PAP method, triglyceride determined by enzymatic GPO-PAP method after subjects had been fasting for approximately 10 hours. LDL-C was calculated by Friedewald equation. Results: These results showed that consumption of tempeh gembus 103 g/day and 206 g/day...