Targeted inactivation of the major positive regulatory element (HS-40) of the human alpha-globin gene locus (original) (raw)
Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster
Stephen Liebhaber
Proceedings of the National Academy of Sciences, 1990
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Coactivation of human α1- and α2-globin genes in single induced MEL cells containing one human α-globin locus
Francois Morle
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1997
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Analysis of enhancer function of the HS-40 core sequence of the human α-globin cluster
Huimin Chen
1997
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Analysis of the human alpha-globin gene cluster in transgenic mice
Dominic Wells
Proceedings of the National Academy of Sciences, 1993
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The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
Andreas Reik
Molecular and Cellular Biology, 1998
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Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice
Dominic Wells
Nucleic Acids Research, 1994
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The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells
Andreas Reik
Molecular and cellular biology, 1998
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Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region
W. Forrester, Elliot Epner
Genes & Development, 1992
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Transcriptional activation of human adult alpha-globin genes by hypersensitive site-40 enhancer: function of nuclear factor-binding motifs occupied in erythroid cells
Thalia Papayannopoulou
Proceedings of the National Academy of Sciences, 1995
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The Locus Control Region Is Necessary for Gene Expression in the Human b-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
Andreas Reik, Elliot Epner
1998
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Deletion of the mouse alpha -globin regulatory element (HS -26) has an unexpectedly mild phenotype
Jacqueline Sharpe
Blood, 2002
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Human ?-globin gene expression is silenced by terminal truncation of chromosome 16p beginning immediately 3? of the ?-globin gene
Stephen Liebhaber
Human Genetics, 1992
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The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers
Michael Antoniou
The EMBO journal, 1988
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A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus
W. Forrester, Elliot Epner
Genes & Development, 1990
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The Chromatin “Landscape” of a Murine Adult β-Globin Gene Is Unaffected by Deletion of Either the Gene Promoter or a Downstream Enhancer
Kathleen McGrath, Steven Fiering
PLoS ONE, 2014
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Distribution of the globin gene in active and inactive chromatin fractions from friend erythroleukemia cells
Anthony Faras
Experimental Cell Research, 1978
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Tissue-specific histone modification and transcription factor binding in globin gene expression
Jacqueline Sharpe
Blood, 2007
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Multiple elements in human β-globin locus control region 5′ HS 2 are involved in enhancer activity and position independent, transgene expression
Dominic Ciavatta
Nucleic Acids Research, 1994
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Epigenetic analysis of the human α- and β-globin gene clusters
Hassana Fathallah
Blood Cells, Molecules, and Diseases, 2008
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An embryonic-specific repressor element located 3′ to the Aγ-globin gene influences transcription of the human β-globin locus in transgenic mice
Eleni Katsantoni
Experimental Hematology, 2004
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Regulation of the Globin Genes
Paolo Moi
Pediatric Research, 2002
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Activation of the beta globin locus by transcription factors and chromatin modifiers
Frank Grosveld
The EMBO Journal, 2000
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Promoters of the murine embryonic -like globin genes Ey and h1 do not compete for interaction with the -globin locus control region
Steven Fiering
Proceedings of the National Academy of Sciences, 2003
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Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region
Ajay Bhargava
Blood, 1994
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Derepression of human embryonic ζ-globin promoter by a locus-control region sequence
Bryan Huang
Proceedings of the National Academy of Sciences, 1998
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Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus
Karin Diderich
Molecular Cell, 2000
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Full Activity From Human β-Globin Locus Control Region Transgenes Requires 5′HS1, Distal β-Globin Promoter, and 3′ β-Globin Sequences
Dylan Pannell
Blood, 1998
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Studies on the in vitro and in vivo expression of a dysfunctional α- globin gene
Surinder Safaya
American Journal of Hematology, 1992
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Analysis of Mice Containing a Targeted Deletion of b-Globin Locus Control Region 59Hypersensitive Site 3
Elliot Epner
1996
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Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes
Michael Antoniou
Genes & Development, 1993
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Regulatory factors specific for adult and embryonic globin genes may govern their expression in erythroleukemia cells
N. Anagnou
Blood, 1985
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Conservation of position and sequence of a novel, widely expressed gene containing the major human α-globin regulatory element
D. Picketts
1995
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Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expression
Dominic Ciavatta
Nucleic acids research, 1994
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High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells
W. Forrester
Proceedings of the National Academy of Sciences, 1990
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DNA sequences required for regulated expression of β-globin genes in murine erythroleukemia cells
A. Athanassiadou
Cell, 1984
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