Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors (original) (raw)
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
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Bioorganic & Medicinal Chemistry, 2010
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Bioorganic & Medicinal Chemistry, 2013
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Bioorganic & Medicinal Chemistry, 2012
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Bioorganic & Medicinal Chemistry Letters, 2016
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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives
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Bioorganic & Medicinal Chemistry, 2012
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Bioorganic & Medicinal Chemistry Letters, 2020
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4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors
Merryl Cramer
Bioorganic & Medicinal Chemistry Letters, 2011
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Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors
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European journal of medicinal chemistry, 2016
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Design, Synthesis of N-(Substituted Imidazo [1, 2-b] Pyridazine) Acetamides and Their Anti-Proliferative Studies on BRAFV600E Mutated A375 and Colo-205 Cell Lines
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Synthesis 2-Bromo-6-(4,5-Diphenyl-1-((1-Phenyl-1H-1,2,3-Triazol-4-yl) Methyl)-1H-Imidazol-2-yl) Pyridine Derivatives: Evaluation of Anticancer Activity and Molecular Docking Studies
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Mechanism of Dimer Selectivity and Binding Cooperativity of BRAF inhibitors
evangelia matenoglou
bioRxiv (Cold Spring Harbor Laboratory), 2023
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Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
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Bioorganic & Medicinal Chemistry, 2012
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Discovery of 3-[2-(Imidazo[1,2- b ]pyridazin-3-yl)ethynyl]-4-methyl- N -{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant
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Bioorganic & Medicinal Chemistry Letters, 2013
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Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma
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Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton′s Tyrosine Kinase (BTK), LFM-A13 [α-Cyano-β-Hydroxy-β-Methyl-N-(2,5-Dibromophenyl)Propenamide]
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CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity
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Molecular Cancer Therapeutics, 2012
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Design, synthesis and docking study of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors
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Small molecule inhibitors of BRAF in clinical trials
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Bioorganic & Medicinal Chemistry Letters, 2012
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Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors
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International Journal of Molecular Sciences
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