Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension (original) (raw)
Related papers
Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension
Clinical Biochemistry, 2003
Objectives: Aim of this study was to evaluate implication of pregnancy induced hypertension on maternal plasma lipid, lipoprotein, apolipoprotein concentrations and lipid peroxidation products by a comparison of normal pregnancy vs. preeclampsia. Design and methods: Thirty-four women with preeclampsia and 32 healthy pregnant women (controls) in the third trimester were recruited for this study. Results: In the preeclamptic group plasma total triglyceride, low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) and apolipoprotein B (apo-B) were significantly increased, while plasma high density lipoprotein cholesterol (HDL-C) was significantly decreased compared to that of control group. There was no significant difference in total cholesterol and apolipoprotein A1 (apo-A1) concentrations. Conclusion: Our findings suggest that preeclampsia share some metabolic characteristics with coronary artery disease such as dislipidemia and increased lipid peroxidation. However lipoprotein concentrations may be better biochemical markers of dislipidemia in the preeclamptic state than the corresponding apolipoproteins.
Serum lipids and malondialdehyde levels in primiparous patients with pregnancy induced hypertension
Indian Journal of Clinical Biochemistry, 2006
BACKGROUND : Pregnancy induced hypertension (PIH) contributes to 15.6% maternal mortality in India. In Behrampur, Orissa, maternal deaths due to PIH was 32%, which is twice the national incidence. Hence in this population, some factors associated with severity of PIH were studied. Serum lipid concentrations and malondialdehyde (MDA) levels were correlated with severity of PIH and birth weight of the neonate Patients & Methods : 70 primiparous PIH patients and 20 healthy controls were studied. Serum lipids and MDA were estimated. Maternal blood pressures and birth weights of the neonate were recorded.
LIPID PEROXIDATION AND LIPOPROTEIN CONCENTRATIONS IN CORD BLOOD OF PREGNANCY INDUCED HYPERTENSION
ABSTRAC¬T Hypertensive disorders complicating pregnancy are common and form one of the deadly triad, along with hemorrhage and infection that contribute greatly to maternal morbidity and mortality. The present study was undertaken to determine the changes in lipid peroxidation and lipoprotein concentrations in cord blood of pregnancy induced Hypertensive patients. The MDA levels in cord blood of Pregnancy induced Hypertension patients. MDA levels were significantly elevated (p < 0.001). Supporting a concept of elevated oxidative stress in fetal circulation in pregnancy induced hypertension. Hydrolysis of Tgs compared with normal gestation, resulting in impaired Generation of LDL particles from Tg rich lipoproteins. Plasma Uric acid in Pregnancy induced Hypertension cases were raised significantly in comparison with controls (p < 0.001). KEYWORDS: lipid peroxidation,pregnancy induced hypertension, lipoprotiens.
Pregnancy induced hypertension: lipid peroxidation and antioxidant status
International Journal of Research in Medical Sciences
Background: Pregnancy is a stressful condition accompanied by a high energy demand and increased oxygen requirement. Oxidative stress has been recognized as a significant factor linked to hypertension. Elucidation of anti-oxidant cascade in patients with pregnancy induced hypertension (PIH). can give insights about the oxidative stress and lead to better management of the condition. It was a prospective case control study to elucidate the parameters of oxidative stress in patients with PIH.Methods: Levels of Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were eludidated using enzyme linked immunosorbent assay (ELISA) in hypertensive mothers and their age matched pregnant and non-pregnant controls to determine the lipid peroxidation and oxidative stress.Results: A total of four hundred and twenty study subjects were enrolled in the study. Malondialdehyde levels from mothers with hypertension were significantly higher than their age matched pregnant controls. The...
Study of serum lipid profile in pregnancy induced hypertension
Indian Journal of Clinical Biochemistry, 2006
Four groups of subjects: normal healthy normotensive nonpregnant women (Group A), normal normotensive pregnant women (Group B), women with preeclamptic toxaemia (Group C) and eclamptic women (Group D): with fifty subjects in each group, were investigated for serum lipid profile in the third trimester of pregnancy. There was significant increase in serum triglyceride and VLDL cholesterol level as well as decrease in LDL cholesterol in normal pregnancy, while total cholesterol and HDL cholesterol levels did not show any statistically significant alteration. The preeclampsia (Group C) was associated with a significant rise in triglyceride and VLDL cholesterol and fall in HDL cholesterol concentration, while eclamptic women showed significant fall in HDL cholesterol and rise in LDL cholesterol as compared to normal pregnant women. However, interestingly, elevation of the ratios of total cholesterol : HDL cholesterol and triglyceride : HDL cholesterol as well as diminuition of the ratio of HDL cholesterol : VLDL cholesterol showed statistical significance in pregnancy induced hypertension in both Groups C and D, while eclamptic women showed significant elevation of LDL cholesterol : HDL cholesterol ratio in addition.
Lipid Profile in Normotensive and Hypertensive Pregnant Women-A Randomized prospective study
Hypertension (HTN) during pregnancy is one of the leading causes of maternal and perinatal morbidity and mortality. The aim of our study was to evaluate the alteration of serum lipid profile during normotensive and hypertensive pregnancy. A cross-sectional comparative study was performed at tertiary care teaching hospital. Blood samples were collected from normal pregnant women(Group 1, n=50) & women with already diagnosed preeclampsia(Group 2, n=50) in third trimesters of pregnancy& concentration of serum triglyceride, VLDL, LDL, totalcholesterol & HDL was compared. Results: Group2 was associated with a significant rise in triglyceride (208.80±7.30 mg%vs. 109.20±1.29 mg %) compared to group1. There wasfall in mean HDL cholesterolconcentration in group2 (37.52 ± 0.74 mg % as against 38.9 mg ± 0.37mg % in group1) (P<0.05). The mean values of total cholesterol in normotensives was 169.74 ± 3.98 mg/dl and in hypertensive 235.40±6.02 mg %) (P<0.0001). Also LDL-cholesterol was significantly increased in group2 (mean 153.88±6.21mg %) and 129.94 ± 3.73 mg % in group1 (P < 0.0001). Very LDL-C was significantly increased in hypertensive pregnancies with mean 45.36 ± 1.99) mg% while in normotensives it was 22.24± 0.71 mg%. We conclude that human gestation is associated with an 'atherogenic' lipid profile that is further enhanced in preeclampsia and this profile may be a potential contributor to endothelial cell dysfunction. We recommend that pregnant female with serum lipid concentrations higher than normal pregnancy should be suspected to development of preeclampsia.
Lipid Profile Changes in Pregnancy Induced Hypertension
Basrah Journal of Surgery
W e tested the hypothesis that the plasma lipid and lipoproteins concentrations are increased markedly in women with pregnancy induced hypertension (PIH) relative to women with uncomplicated pregnancy and that these lipids de crease postpartum and to clarify the relation of lipid profile changes with the severity of pregnancy induced hypertension. This study is a prospective, case-control study conducted at Basrah Maternity and Child Hospital extended through a period of 12 mo nths from the first of August 2000 till the first of August 2001. Pre-labor venous blood samples were collected for 90 women with pregnancyinduced hypertension and 110 women with normal uncomplicated pregnancy with an age range (16-40) years and gestational age range (34-42) weeks after 12 hours fasting. Venous blood samples were also collected from only 30 women with PIH and 30 women with normal uncomplicated pregnancy after 24-48 hours postpartum. Serum was analyzed for concentrations of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C). Pre-labor serum (TG), (TC), (LDL-C) and (VLDL-C) were increased in women with PIH relative to uncomplicated pregnancies respectively P value (<0.001). (HDL-C) concentration does not differ between studied groups (P = 0.1). Concentrations of all lipids decreased significantly (P value <0.001) in both groups within the first 24-48 hours postpartum. However the levels of these lipids remained higher in women with PIH but were statistically not significant. Serum triglyceride and VLDL concentrations but not total cholesterol, HDL-C and LDL-C were significantly higher in severe PIH group in comparison with mild PIH. There was no correlation between the age, parity and the lipid profiles changes in both groups. There was a positive correlation between each of the (TG), (TC), (LDL-C) and (VLDL-C). (HDL-C) does not correlate significantly with other different types of lipid. In conclusion, plasma lipids and lipoproteins but not HDL-C are increased in PIH relative to normal pregnancy and hypertriglyceridemia found in severely PIH may contribute to endothelial dysfunction in PIH.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Pregnancy induced hypertensive disorders are one of the commonest complication of pregnancy which accounts for 12% of the maternal and perinatal mortality and morbidity. Dyslipidemias are associated with endothelial dysfunction that may result in proteinuria and hypertension which is a clinical hallmark of PIH. It affects both maternal health as well as fetal growth. Hence, this study was done to assess the role of altered lipid profile in the development of PIH.Methods: A Case Control study was conducted at the Department of Biochemistry, Kurnool Medical College and Govt General Hospital, Kurnool in collaboration with its Obstetrics Dept during the period of November 2015-2017. A total of 300 pregnant women, primigravida /multigravida with singleton pregnancy, in the age group of 18‐ 35 years with >20 weeks of gestation were included in the study. Subjects were divided into gestational hypertensives, n=39 (BP ≥140/80) and preeclamptic women, n=111 (≥140/80 and protei...
Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia
Gynecological Endocrinology, 2005
Aims. To evaluate changes in lipid profile, serum levels of malondialdehyde (MDA) and lipoprotein(a) (Lp(a)) and placental MDA in preeclamptic women, and to evaluate the atherogenic role of these changes in the pathophysiology of preeclampsia. Method. A cross-sectional study was performed in 20 normal pregnant women, 25 women with mild preeclampsia and 28 women with severe preeclampsia in the third trimester. MDA, which is the endproduct of lipid peroxidation, was measured in placental tissue by the thiobarbituric acid (TBA) method of Ohkawa and colleagues and in serum by the TBA method of Asakawa and Matsushita. Serum lipid levels were measured by with an autoanalyzer, serum apolipoprotein (Apo) A-I and Apo B were measured by nephelometric assay and serum Lp(a) level using a nephelometric agglutination assay method. In preeclamptic and normal pregnant women, multiple comparisons between groups were performed by one-way analysis of variance supplemented with Tukey's HSD post hoc test. The association between placental and serum concentrations among groups was analyzed using the Pearson correlation test. Results. Serum levels of MDA, Lp(a), total cholesterol, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and placental MDA were significantly higher, and high-density lipoprotein cholesterol (HDL-C) and Apo A-I levels were significantly lower, in severely preeclamptic and mildly preeclamptic women than in the normal pregnant women, but no difference was observed in Apo B among groups. Serum level of Lp(a) was positively correlated with body mass index in severely preeclamptic women (r = 0.489, p = 0.008). A significant positive correlation was also found between serum level of MDA and systolic blood pressure in women with severe preeclampsia (r = 0.375, p = 0.049). Conclusions. Our findings suggest that high Lp(a), lipid peroxidation, LDL-C and TG, and low HDL-C and Apo A-I levels, are important risk factors for atherosclerosis among preeclamptic women.