Metastasis to Paranasal Sinuses as the First Presenting Sign of Renal Cell Carcinoma (original) (raw)
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Renal Cell Carcinoma Metastasis to the Sinonasal Cavity: Case Report
Acta clinica Croatica, 2015
Renal cell carcinoma accounts for 3% of all adult malignant tumors. Common sites of metastases are lungs, bone, liver, brain and adrenal glands. Metastatic disease to the head and neck ranges from 15% to 30%. The 5-year survival rate after nephrectomy is 60%-75%, but with multiorgan metastases the 5-year survival rate is significantly lower, 0-7%. A case is presented of a female patient diagnosed with renal cell carcinoma metastases to the paranasal sinuses, diagnosed and treated at the Department of ENT and Head and Neck Surgery, Zadar General Hospital, Zadar, Croatia. The tumor was surgically removed. Unfortunately, the patient died one year after the procedure due to multiorgan failure. Although metastases of renal cell carcinoma to the head and neck are very rare, it should be first suspected when investigating a metastatic tumor in this region. Surgical excision offers the best hope for long term survival. In case of unresectable tumor, other treatment options should be conside...
Distant metastases to nasal cavities and paranasal sinuses case series
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2011
Metastatic tumors to the nasal cavity and paranasal sinuses are far less common than primary cancer in this location. Review of the 2004-2010 pathology records of patients with sinonasal malignancy, revealed three cases with distant metastases to this region from primary sites in kidney, prostate and breast. The clinical presentation, histopathological findings and clinical outcome is presented for each patient. Metastases to the nose and paranasal sinuses usually respond poorly to treatment and have a poor prognosis. This report highlights the importance of suspecting metastases in patients with a previous history of malignancy. Therefore, thorough history and clinical evaluation is mandatory in any known/treated case of cancer.
Ear, nose, & throat journal, 2012
The paranasal sinuses are a rare location for metastases. The most frequent infraclavicular primary tumor to metastasize to the nose and paranasal sinuses is renal cell carcinoma. Three cases of bilateral renal cell carcinoma with metastases to the paranasal sinuses and with destruction of the skull base are reported. These patients had a primary renal cell carcinoma on the left side for which they had undergone a left nephrectomy many years previously. Right-sided renal cell carcinoma was diagnosed only after the patients had developed symptoms secondary to their metastases. These patients presented with the unusual manifestations of frontal swelling, proptosis, and epistaxis. They were offered palliative treatment in the form of radiotherapy and interferon therapy.
Paranasal Sinus Malignancies – A 6 Year Tertiary Hospital Experience
Indian Journal of Applied Research, 2011
To illustrate our experience in the demographics, tumour characteristics and management of paranasal sinus malignancies during an 6-year time period. MATERIALS AND METHODS: This is a retrospective, observational study where clinical data of 41 patients diagnosed and treated for paranasal sinus malignancies were analysed. RESULTS: The male:female ratio was 1.6:1 and the median age of presentation was 48 years. The most common presenting symptom was epistaxis (46.4%). The median time gap between the onset of symptoms and presentation was 3 months. The maxillary sinus was the most commonly affected site (68%) and the most common malignancy was squamous cell carcinoma(39%). 90% of the patients underwent surgery as part of a multimodality curative treatment plan or alone as curative treatment. CONCLUSION: Advanced T stage, regional and distant metastasis of paranasal sinus malignancies are highly predictive of poor survival. Hence early diagnosis and treatment is of immense value in decreasing the morbidity and mortality due to these tumors.
Management of malignant tumours of the paranasal sinuses
Indian Journal of Otolaryngology and Head & Neck Surgery, 1984
Observations stasis. Besides, one more case paranasal sinuses are fortunately undeveloped nodal metastasis a few common. Lewis (1972) mentioned Age and sex : The age of patients months after the treatment of primary that cancer of the nasal cavity and varied from 8 years to 75 years lesion in the maxillary sinus. Thus, paranasal sinuses comprise about 2% (Table I). nine cases had nodal involvement at of cancers of the human body. some stage of their disease. Of According to Sisson and Becker TABLE I these, eight cases had squamous-cell (1981), malignant tumours of the Age and sex prevalence-_ carcinoma and one had adenocarcinose and paranasal sinuses make up Age groups No. of cases noma. 0.5% of all body tumours and 3% of 0-20 years 8 all tumours of the respiratory tract.
Background: Inadequate epidemiologic investigations of the paranasal sinuses malignancies prompted this retrospective study with special emphasis on a major group of 111 tumors. Material and Methods: Clinical records of 111 patients with histologically confirmed malignant tumors of the paranasal sinuses were investigated retrospectively from April 2000 to January 2012. Collection of data included demographic information, clinical manifestations, treatment plans, and histopathology of the tumor. Results: There were 69 (62.16%) male and 42 (37.83%) female patients (male-to-female ratio of 1.6:1), with a median age of 49±12.2 years (range 21 to 88 years). A high level of occurrence was noticed in the fifth (26.3%) decade of life. The most frequent histological types were squamous cell carcinoma (43.5%) and adenoid cystic carcinoma (19%). Among clinical manifestations, nasal obstruction was the most frequent followed by diplopia, and facial swelling. Fifty three patients (47.74%) were treated with combined approach of surgery and radiation therapy. Conclusions: Paranasal sinuses malignancies are rare conditions with nonspecific symptoms which make early diagnosis of the lesions more challenging. The optimal therapeutic protocol for patients suffering from these tumors is still a somewhat controversial entity and requires further studies.
Transitional Cell Carcinoma Paranasal Sinuses- Significance
Indian Journal of Applied Research, 2011
The transitional cell sinonasal carcinomas are rare, non keratinizing variant of squamous cell carcinoma. This commonly involves the sinonasal tract and estimated incidence is 2-11 percent. But it can aiso involve the nasopharynx, base of tongue and hypopharynx. There are little data on the biological behaviour of these tumours. Treatment is usually on the lines of squamous cell carcinoma. In this paper we attempt to discuss the clinical presentation, radiology, histopathological features and clinical features of this infrequently encountered tumor by means of three cases, which we encountered