A Comprehensive Review On Pelletization Technology: A Novel Strategy For Formulation Development (original) (raw)

Recent Advances In Pelletization Technique for Oral Drug Delivery: A Review

Current Drug Delivery, 2009

Multiparticulate dosage forms are receiving a great deal of attention as alternative system for oral drug delivery. The present review outlines the recent findings on the manufacturing and evaluation of spherical pellets published over the past decade. The techniques namely extrusion-spheronization, hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with parameters affecting pelletization. Evaluation of quality of the pellets is discussed with reference to the size distribution, shape, surface morphology, specific surface area, friability, tensile strength, density, porosity, disintegration time and in vitro dissolution studies of pellets. The use of multiparticulate dosage forms as a promising system for the oral delivery of many therapeutic agents has also been examined in the current review.

Controlled-Release Pelletized Dosage Forms Using the Extrusion-Spheronization Process

Journal of Pharmaceutical Investigation, 2010

Pellets, which are multiple-unit dosage systems, have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. This review focuses on the current status and explores extrusion-spheronization technique with special attention to controlled-release application of pellets including coated pellets for delayed release formulations, coated pellets for colon delivery, coated pellets for sustained drug delivery, sustained-release matrix pellets, pellets compressed into tablets, bioadhesive pellets, floating pellets, and pelletization with solubilization techniques.

Pelletization Techniques for Oral Drug Delivery

Multiparticulates are discrete particles that make up a multiple unit system. Although pellets have been used in the pharmaceutical industry for more than four decades, with the advent of controlled release technology, that the full impact of the inherent advantages of pellets over single unit dosage forms have been realized, not only has focused on refining and optimizing existing pelletization techniques, but also focused on the development of novel approaches and procedures for manufacturing of pellets. The present review outlines the manufacturing and evaluation of pellets. The manufacturing techniques include layering, cryopelletization, freeze pelletization, extrusion spheronization and hot melt extrusion have been discussed. Characterization of pellets is discussed with reference to the particle size distribution, surface area, porosity, density, hardness, friability and tensile strength of pellets.

An Outline of Variables in Pelletization by Extrusion and Spheronization

International Journal of Applied Pharmaceutics

Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs into small, free-flowing, spherical units, known as pellets. The pelletization can be achieved either through agitation, compaction (extrusion-spheronization), drug layering and globulation. Among the various pelletization techniques extrusion–spheronization process is preferred over other methods for the preparation of pellets as it allows the incorporation of the higher amount of drug, modified physical characteristics of the drug (density, sphericity, narrow size distribution, smoother surface) and multiple drugs can be easily combined in the same unit. This current review summarizes the findings or investigations by the researchers on various variables, including process parameters, equipment parameters and formulation parameters influencing the quality of pellets. The article also focuses on process optimization and additives used in pellets formulation. To prepare the current review...

AN OUTLINE OF VARIABLES IN PELLETIZATION BY EXTRUSION AND SPHERONIZATION Review Article

International Journal of Applied Pharmaceutics, 2020

Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs into small, free-flowing, spherical units, known as pellets. The pelletization can be achieved either through agitation, compaction (extrusion-spheronization), drug layering and globulation. Among the various pelletization techniques extrusion-spheronization process is preferred over other methods for the preparation of pellets as it allows the incorporation of the higher amount of drug, modified physical characteristics of the drug (density, sphericity, narrow size distribution, smoother surface) and multiple drugs can be easily combined in the same unit. This current review summarizes the findings or investigations by the researchers on various variables, including process parameters, equipment parameters and formulation parameters influencing the quality of pellets. The article also focuses on process optimization and additives used in pellets formulation. To prepare the current review search criterion used was the parameters affecting final pellet characterization in the extrusion spheronization process. The sources were peer-reviewed relevant scientific articles of recognized journals. Keywords used as filters were extrusion, spheronization, formulation parameters, process parameters, equipment parameters, moisture content, granulating liquid, drying rate, extrusion temperature, spheronizer load, pelletization. Literature survey has been done in a range of years (1992-2019) regarding the various variables of the extrusion spheronization process, which affects and has foremost impact on the final quality of pellets so as to make the review updated and comprehensive.

Pelletization Techniques. The Pharma Review

International Journal of Scientific Research in Science and Technology

Pellets are spherical or nearly spherical, free-flowing granules with a narrow size distribution, typically varying between 500 and 1500 µm for pharmaceutical applications. They are generally produced via a pelletization process whereby a powder blend consisting of an API and excipients particles is agglomerated into spherical granules. This review article deals with various aspects of the extrusion–spheronization technique. Pelletization is a technique to convert drugs or excipients to small free flowing, spherical or semi spherical units, which are produced by agglomerating fine powdered drugs/ excipients with a binder solution. Pellets range in size, typically, between 0.5 – 2 mm. In relation to pharmaceuticals, pellets offer high degree of flexibility in design and development of oral dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage form...

Pharmaceutical Pellets: A Versatile Carrier for Oral Controlled Delivery of Drugs

Indian Journal of Pharmaceutical Education and Research, 2016

In pharmaceutical industries, pellets are multiparticulate dosage form which was formed by the agglomeration of fine powdered excipient and drugs together that leads to the formation of small free flowing spherical or semi spherical particles. This technique is called as pelletization process. Pellets are typically varied between 500-1500 µm in size for pharmaceutical applications. It is of great interest over other similar techniques due to its uniformity of dose, less susceptibility of dose dumping, less friability etc. With the advent of controlled release technology, drug loaded pellets have been widely investigated for its control release property in gastrointestinal tract. This review will provide an insight into previous studies on pelletization techniques, investigation of various pelletization techniques namely: layering, extrusion spheronization, cryopelletization, hot melt extrusion. It also gives a brief idea about the evaluation of pellets; parameters affecting pelletization, the different available marketed pellet formulation.

Influence of microstructure on drug release from extrusion-spheronization pellets

Journal of Drug Delivery Science and Technology, 2010

The microporous structure of pellets produced by extrusion-spheronization is the outcome of the combination of all the variables involved in the process, including composition and every technological step. Frequently, the result of such a combination of variables is complex and barely studied, and thus there is still a paucity of information regarding the influence of the microporous structure on features as relevant as mechanical resistance, adhesion to substrates and, importantly, drug release kinetics. This review aims to gain an insight into these issues through an analysis of the studies carried out in recent years on this topic. These include the microstructure and drug release behavior of conventional pellets based on microcrystalline cellulose (MCC) and matrix pellets based on acrylic polymers (Carbopol), all of them prepared by extrusion-spheronization. These topics are examined in detail and, when possible, correlations between parameters are highlighted. Examples of the incidence of pellet microstructure on the features of tablets are also given.

MULTIPLE UNIT DOSAGE FORM -PELLET AND PELLETIZATION TECHNIQUES: AN OVERVIEW

Pellets have been used in the pharmaceutical industry for more than four decades, with the advent of controlled release technology, that the full impact of the inherent advantages of pellets over single unit dosage forms have been realized, not only has focused on refining and optimizing existing pelletization techniques, but also focused on the development of novel approaches and procedures for manufacturing of pellets. The present review outlines the manufacturing and evaluation of pellets. There are various types of pelletization techniques like spheronization and extrusion, pelletization by layering, pelletization by solution layering & direct pelletization. The techniques namely extrusion-spheronization, hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with parameters affecting pelletization.