Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice (original) (raw)

The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism

Francisco Gómez-pérez

Current Diabetes Reviews, 2009

View PDFchevron_right

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo

Ffolliott Fisher

Endocrinology, 2011

View PDFchevron_right

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

Murielle Veniant

AJP: Endocrinology and Metabolism, 2009

View PDFchevron_right

FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance

Saswata Talukdar

Scientific reports, 2015

View PDFchevron_right

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

hashem nayeri

Hormone and Metabolic Research

View PDFchevron_right

Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice

Nils Bergenhem

Molecular Therapy - Nucleic Acids

View PDFchevron_right

Metabolic actions of fibroblast growth factor 21

Francisco Gómez-pérez

Current Opinion in Pediatrics, 2012

View PDFchevron_right

Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis

Eleni Domouzoglou

American Journal of Clinical Nutrition, 2011

View PDFchevron_right

Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes

Anja Böhm

Molecular metabolism, 2015

View PDFchevron_right

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Ffolliott Fisher

Diabetes, 2010

View PDFchevron_right

Interplay between FGF21 and insulin action in the liver regulates metabolism

Kristin Stanford

Journal of Clinical Investigation, 2014

View PDFchevron_right

Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats

Wanpitak Pongkan

Diabetes and Vascular Disease Research

View PDFchevron_right

Minireview: Roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases

Lu Cai

Molecular endocrinology (Baltimore, Md.), 2015

View PDFchevron_right

Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet

Sudathip Sae-tan

The Journal of nutrition, 2016

View PDFchevron_right

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

Ffolliott Fisher

Gastroenterology, 2010

View PDFchevron_right

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Murielle Veniant

Endocrinology, 2012

View PDFchevron_right

Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice

Ryan Sheldon

Experimental physiology, 2018

View PDFchevron_right

FGF-21 as a novel metabolic regulator

George Sandusky

Journal of Clinical Investigation, 2005

View PDFchevron_right

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

Joshua Thaler

Diabetes, 2010

View PDFchevron_right

The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy

Martin Braddock

Metabolism: clinical and experimental, 2015

View PDFchevron_right

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

Julie Serr

Endocrinology, 2013

View PDFchevron_right

Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21

An Chi

PLoS ONE, 2013

View PDFchevron_right

Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets

Ffolliott Fisher, Jeremy Cunniff

Gastroenterology, 2014

View PDFchevron_right

Serum FGF21 Levels Are Increased In Obesity and Are Independently Associated With the Metabolic Syndrome In Humans

Michal Karpisek

Diabetes, 2008

View PDFchevron_right

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice

Stephen Twigg

2018

View PDFchevron_right

FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity

A. Pettersson, Mikael Rydén

FEBS Letters, 2008

View PDFchevron_right

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

Bruce Hultgren

Endocrinology, 2002

View PDFchevron_right

The Role of Fibroblast Growth Factor 21 as an Endocrine Regulator of Lipid Metabolism: From Progression to Pathophysiology and Physiology

Dr.Inam- U-llah

Pakistan Journal of Medical and Health Sciences

View PDFchevron_right

Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

Ralph DeFronzo

Diabetes Care, 2009

View PDFchevron_right

MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21

sara romero

2012

View PDFchevron_right

Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes

Roberto A Calle

PLoS ONE, 2014

View PDFchevron_right

Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

Ruby Hoo

Journal of Biological Chemistry, 2011

View PDFchevron_right