Contributing Factors to the Quality of Life in Multiple Sclerosis (original) (raw)
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Relation of cognitive impairment and depression to quality of life in multiple sclerosis patients
The Italian Journal of Neurological Sciences, 1998
The objectives of the present study were to determine the role of cognitive and mood disorders as determinants of health-related quality of life (HRQOL) in multiple sclerosis (MS), as well as to evaluate the validity of self-assessed HRQOL in cognitively impaired patients and the agreement between self-assessed and proxy-reported HRQOL. The study included 204 MS inpatients and outpatients seen between April and September 1997 at three participating centers. The MS quality of life 54 (MSQOL-54) was explained to the patients by a neurologist who also assisted them to complete the questionnaire. A proxy version of the MSQOL-54 was completed independently by each patient's designated proxy.
Quality of life among persons suffering from multiple sclerosis
2019
Objective: To examine the quality of life of people affected by multiple sclerosis and to determine whether there is a difference in the quality of life according to sex, age, education, employment status, marital status and overall duration of the disease. Materials and methods: The study included 81 patients with MS (32 men and 49 women) over 18 years of age. The survey instrument used was a standardized MSQoL-54 specific questionnaire for measuring the quality of life of patients with multiple sclerosis. Results: Men rated their health significantly better than women in dimensions of energy/vitality (p = 0.028) and dimensions of pain (p = 0,018), while women rated significantly better in the dimension health perceptions (p = 0.025). The dimensions of health that described physical health (p < 0.001), pain (p = 0.047), sexual functioning (p = 0.036), social functioning (p = 0.047) and overall quality of life (p = 0.012) were significantly worse rated by the oldest respondents. Ratings of physical health (p < 0.001) and overall quality of life scale (p = 0.017) were significantly the lowest in subjects older than 55 years. According to the level of education, significant differences were present only in dimensions to energy/vitality (p = 0.004) and health distress (p = 0.015). As regards to employment status, dimensions that described physical health (p = 0.001), health perception (p = 0.001), social function (p = 0.002), health distress (p = 0.010), overall quality of life (p = 0.009), physical health composite (p = 0.001), mental health composite (p = 0.007) and overall quality scale of quality of life (p = 0.003) were the significantly worse rated respondents. According to disease duration the lowest rating to quality of physical health was given by respondents suffering from MS for 21 years and longer (p = 0.007). Conclusion: Research shows that multiple sclerosis impairs the quality of life of patients. The use of instruments designed to measure multiple sclerosis patients' quality of life, based on subjective perceptions of quality of life, facilitates the implementation of targeted interventions and measures that improve the quality of life.
Quality of Life of People with Multiple Sclerosis:Clinical and Psychosocial Determinants
Procedia - Social and Behavioral Sciences, 2015
Multiple sclerosis (MS) is an unpredictable, inflammatory, chronic, potentially disabling, neurological disease which is very common in young adults. It is of unknown origin there is no available curative treatment as of yet. Consequently, studying the quality of life (QOL) of people with MS people is an important aspect in assessing the impact of the disease on their daily lives. Through a cross-sectional, quantitative study, we enquired a random sample of 54 Portuguese MS patients, mostly female (61.1%), married (72.2%), aged between 20 and 67 years (M=42.11; SD=11.728), employed (37.0%), in which the mean age at onset was 33 years. The following are the measurement instruments used:
Quality of life assessment in patients with multiple sclerosis
Vojnosanitetski pregled, 2009
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. The main physiopatological feature of MS is demyelination. Multiple sclerosis is one of three most common causes of severe disability in youngest people. In patients with MS, apart from complete psychophysical status and objective neurologic status, a subjective perception of symptoms and signs, known as quality of life, must be considered, too. The aim of this study was to estimate a health related quality of life (HRQoL) in patients with multiple sclerosis (MS) and to investigate the correlations between scores of HRQoL and selected demographic and clinical parameters. A cross-sectional study was performed in patients meeting following inclusion criteria: MS diagnosis (McDonald&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s criteria), age 18-60 years, the Expanded Disability Status Scale (EDSS) &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 8, and written informed consent. Exclusion criteria were exacerbation of MS in the last month, any preexisting major chronic illness and/or psychiatric disorders and antidepressive and/or corticosteroid therapy in the last month. The quality of life was measured by a disease specific instrument, MSQoL-54 (The Multiple Sclerosis Quality of Life). The neurological impairment was assessed using the Expended Disability Status Scale (EDSS) and Mini Mental Scale (MMS). The presence and severity of depression was estimated by the Hamilton Depression Rating Scale (HDRS). The presence and severity of fatigue was assessed by the Fatigue Severity Scale (FSS). Statistical analysis included descriptive statistics and correlation analysis. The higher HRQoL score was registered for mental health (56.3 +/- 19.5) than for physical one (51.3 +/- 17.9), which means that physical disability had more important influence on quality of life deterioration comparing to mental health. The highest values of HRQoL were observed in domains of Cognitive Functioning (77.4 +/- 22.5) and Pain (75.7 +/- 25.5). The lowest scores of HRQoL were registered in domains of Role Limitations due to Physical Problems (32.5 +/- 42.0) and Role Limitations due to Emotional Problems (44.6 +/- 47.8). HRQoL scores statistically significantly correlated with natural history of MS, duration of diseases, employment and marriage status of participants. Deterioration in quality of life scores in the most of MSQoL-54 scales and subscales statistically significantly correlated with the presence and severity of physical disability, depression status and fatigue in patients with MS. This study showed that different demographic and clinical parameters had a major influence on HRQoL impairment in the sample of patients with MS.
European Journal of Neurology, 2002
The existing knowledge about the health-related quality of life (HRQoL) and its relationship to cognitive and/or emotional functioning in multiple sclerosis (MS) is scarce. We assessed differences between subgroups of MS outpatients (n ΒΌ 209) on one HRQoL instrument: a version of the Functional Assessment of Multiple Sclerosis quality of life instrument; on two cognitive functioning tests: the Mini-Mental State Examination and the clock drawing test; and on two emotional functioning tests: the Hamilton Rating Scale for Depression and the Hamilton Rating Scale for Anxiety. Three disease-related characteristics were assessed: physical disability, duration of the illness, and clinical course. The results showed that each of these has an effect on at least one dimension of HRQoL and on one mental functioning test. Thus, the more severe, the more progressive, and the longer the illness duration, the lower the HRQoL. Likewise, cognitive mean scores decreased and emotional mean scores increased with greater illness severity and progressive the MS. Furthermore, we also found significant correlations between cognitive and emotional functioning tests and HRQoL dimensions. Thus, the worse cognitive functioning and the higher depressive and anxiety symptoms score the lower the HRQoL.
A review about the impact of multiple sclerosis on health-related quality of life
Disability and Rehabilitation, 2003
Purpose: There is increasing recognition that the global wellbeing of patients with chronic neurological disease is an important outcome in research and clinical practice alike. Many studies involving individuals with multiple sclerosis have demonstrated that the overall wellbeing is not a simple manifestation of impairment or disability. The strongest correlations with health-related quality of life appear to be patient rated emotional adjustment to illness and patient rated handicap. In recent years, health-related quality of life questionnaires that measure the physical, social, emotional, and occupational impact of illness have been developed and validated in populations with MS. Most questionnaires are now available in a range of languages. This development is likely to lead to increasing recognition of neuropsychiatric complications of MS in clinical practice and better quantification of treatment responses in clinical trials. Conclusion: Further work is required to decide which scale is most suited to which purpose. Assessment of multiple sclerosis-specific health-related quality of life should be included in future clinical trials to provide a complete picture of patients' health status.
Multiple Sclerosis, 2007
KV, et al. Deterioration in health-related quality of life of persons with MS: the possible warning signs. Mult Scler. 2007;13:1038-1045. Phillips LJ, Stuifbergen A. Influence of positive experiences on depression and quality of life in persons with MS. J Holist Nurs. 2008;26:41-48. Rossen EK. Commentary [on the study of Phillips and Stuifbergen]. J Holist Nurs. 2008;26:49. Buhse M. Assessment of caregiver burden in families with MS.
Cognitive function and quality of life in multiple sclerosis patients: a cross-sectional study
BMC Neurology, 2011
Background Nearly half of all patients diagnosed with multiple sclerosis (MS) will develop cognitive dysfunction. Studies highlighted from no/weak impact to a strong impact of cognitive impairment on quality of life (QoL). The aim of this study was to assess the impact of cognitive dysfunction on self-reported QoL in MS patients while considering key confounding factors. Methods Design: cross-sectional study. Inclusion criteria: MS patients of any disease subtype. Data collection: sociodemographic (age, gender, marital status, education level, and occupational activity) and clinical data (MS subtype, disease duration); MS disability (Expanded Disability Status Scale, EDSS); depression (Beck Depression Inventory); fatigue (Modified Fatigue Impact Scale); QoL (SF36 and MusiQoL); and neuropsychological performance (Brief Repeatable Battery of Neuropsychological Tests, BRB-N). Statistical analysis: multiple linear regressions (forward-stepwise selection). Results One hundred and twenty-...
PLoS ONE, 2012
Background: Cognitive impairment occurs in about 50% of multiple sclerosis (MS) patients, and the use of self-reported outcomes for evaluating treatment and managing care among subjects with cognitive dysfunction has been questioned. The aim of this study was to provide new evidence about the suitability of self-reported outcomes for use in this specific population by exploring the internal structure, reliability and external validity of a specific quality of life (QoL) instrument, the Multiple Sclerosis International Quality of Life questionnaire (MusiQoL). Methods: Design: cross-sectional study. Inclusion criteria: MS patients of any disease subtype. Data collection: sociodemographic (age, gender, marital status, education level, and occupational activity) and clinical data (MS subtype, Expanded Disability Status Scale, disease duration); QoL (MusiQoL and SF36); and neuropsychological performance (Stroop color-word test). Statistical analysis: confirmatory factor analysis, item-dimension correlations, Cronbach's alpha coefficients, Rasch statistics, relationships between MusiQoL dimensions and other parameters.