Clinical speech impairment in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy (original) (raw)
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Motor speech disorders in three parkinsonian syndromes: a comparative study
2007
ABSTRACT This paper presents results of an acoustic investigation of speech in progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and idiopathic Parkinson's disease (IPD). The study had two aims:(a) to provide a first acoustic description of the speech of people with PSP and MSA,(b) to compare acoustic characteristics of the dysarthria associated with PSP and MSA with classic hypokinetic dysarthria.
Speech disorders in Multiple System Atrophy of Parkinson Type
2007
Multiple system atrophy (MSA) is characterized clinically by the combination of Parkinsonian, pyramidal, cerebellar, and autonomic symptoms. If parkinsonism predominates in the clinical picture of the disease, the condition is named striatonigral degeneration or MSA type P (P stands for parkinsonism). A 67 years’ old woman with a previous clinical diagnosis of striatonigral degeneration and a five year history of the symptoms had initially been misdiagnosed as suffering from Parkinson’s disease. However, she did not respond well to levodopa and soon developed severe dysarthria. The neurological features, helpful in differentiating MSA type P from other extrapiramidal disorders, included falling, dysarthria and dysphonia, respiratory stridor, hyperreflexia and ataxia. Cerebellar signs were well manifested, whereas autonomic symptoms were less severe. Besides neurological and imaging study, a specially designed Speech Efficiency Test for dysarthria was performed. It revealed numerous ...
BMJ Open, 2016
Introduction: Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese). Methods and analysis: Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life. Ethics and dissemination: The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable largescale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.
Journal of Neural Transmission, 2020
Clear speech refers to intentionally modifying conversational speech to maximise intelligibility. This study aimed to compare the speech behaviour of patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and Parkinson's disease (PD) under conversational and clear speech conditions to gain greater pathophysiological insight. A total of 68 participants including 17 PD, 17 MSA, 17 PSP and 17 healthy controls (HC) performed two readings of the same standardized passage. During the first reading, participants were instructed to read the text in an ordinary way, while during the second reading to read the text as clearly as possible. Acoustic analyses were based upon measurements of mean loudness, loudness variability, pitch variability, vowel articulation, articulation rate and speech severity. During clear speech production, PD patients were able to achieve improvements mainly in loudness (p < 0.05) and pitch variability (p < 0.001), leading to a reduction in overall speech severity (p < 0.001), whereas PSP and MSA patients were able to modulate only articulation rate (p < 0.05). Contrary to HC and PD groups, which slowed or maintained articulation rate, PSP and MSA groups employed a markedly faster articulation rate under the clear speech condition indicating an opposing approach to speech adaptation. Patients with atypical Parkinsonism showed a different strategy to intentionally improve their speech performance following a simple request to produce speech more clearly compared to PD, suggesting important therapeutic implications for speech rehabilitation management.
Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease
npj Parkinson's Disease
Substantial variability and severity of dysarthric patterns across Parkinson’s disease (PD) patients may reflect distinct phenotypic differences. We aimed to compare patterns of speech disorder in early-onset PD (EOPD) and late-onset PD (LOPD) in drug-naive patients at early stages of disease. Speech samples were acquired from a total of 96 participants, including two subgroups of 24 de-novo PD patients and two subgroups of 24 age- and sex-matched young and old healthy controls. The EOPD group included patients with age at onset below 51 (mean 42.6, standard deviation 6.1) years and LOPD group patients with age at onset above 69 (mean 73.9, standard deviation 3.0) years. Quantitative acoustic vocal assessment of 10 unique speech dimensions related to respiration, phonation, articulation, prosody, and speech timing was performed. Despite similar perceptual dysarthria severity in both PD subgroups, EOPD showed weaker inspirations (p = 0.03), while LOPD was characterized by decreased v...
Interspeech 2017
Parkinson's disease (PD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA) are distinctive neurodegenerative disorders, which manifest similar motor features. Their differentiation is crucial but difficult. Dysfunctional speech, especially dysprosody, is a common symptom accompanying PD, PSP, and MSA from early stages. We hypothesized that automated analysis of monologue could provide speech patterns distinguishing PD, PSP, and MSA. We analyzed speech recordings of 16 patients with PSP, 20 patients with MSA, and 23 patients with PD. Our findings revealed that deviant pause production differentiated between PSP, MSA, and PD. In addition, PSP showed greater deficits in speech respiration when compared to MSA and PD. Automated analysis of connected speech is easy to administer and could provide valuable information about underlying pathology for differentiation between PSP, MSA, and PD.
Speech disorders in Parkinson’s disease - characteristics, assessment and treatment
Medical review, 2021
Introduction. Parkinson?s disease belongs to the group of extrapyramidal neurodegenerative diseases and occurs as a consequence of the loss of dopaminergic neurons in the substantia nigra of the mesencephalon. Persons with Parkinson?s disease may experience a wide range of motor and non-motor symptoms. Material and Methods. A literature search was conducted using electronic databases on the Internet and electronic databases of Serbian libraries. Results. Speech disorders in Parkinson?s disease are classified in the group of hypokinetic dysarthria. Empirical data show that the basic characteristics of dysarthria in people with Parkinson?s disease are changes in voice quality, difficulties in articulating consonants, abnormalities in vowel production, monotonous speech, changes in speech rate, rough and breathy voice, increased voice nasality, reduced intensity of voice, involuntary pauses during speech, and palilalia. Methods used in the assessment of speech disorders include percept...
Processing of Pathological Changes in Speech Caused by Dysarthria
International Symposium on Intelligent Signal Processing and Communication Systems, 2005
Computer analysis of voice isolated sounds may lead to identification of parameters correlated with neurological diseases. This paper presents results of preliminary research of voice pathological changes caused by dysarthria. The selection of linguistic material was characterized according to the place and manner of articulation in the phonetic system of Polish. Results of clinical examination allowed to determine simple markers of neurodegenerative diseases, which will serve as a basis for construction of objective examination model.
Speech characteristics of parkinson disease
Medical Science and Discovery, 2021
Objective: Parkinson Disease (PD) is known the second most frequent neurodegenerative age-related disorder after Alzheimer’s disease. Although over the six million people worldwide suffer from PD, the main cause of the disease remains are unknown. Speech and language impairments have emerged in most patients with PD during the course of the disease. However, clinical profiles or characteristics that might differentiate individuals with PD who are predisposed to speech and language deficits are generally overlooked. Moreover, factors that expedite language disability have still been remained elusive. It is thought that the awareness of speech and language impairments in PD can significantly help to maintain language abilities as the disease progresses and also may contribute to improving communication skills with patients. For this reason, the present study aims to constitute a comprehensive frame for the speech and language characteristics of individuals with PD
Speech disorders did not correlate with age at onset of Parkinson’s disease
Arquivos de Neuro-Psiquiatria, 2016
Speech disorders are common manifestations of Parkinson´s disease. Objective To compare speech articulation in patients according to age at onset of the disease. Methods Fifty patients was divided into two groups: Group I consisted of 30 patients with age at onset between 40 and 55 years; Group II consisted of 20 patients with age at onset after 65 years. All patients were evaluated based on the Unified Parkinson’s Disease Rating Scale scores, Hoehn and Yahr scale and speech evaluation by perceptual and acoustical analysis. Results There was no statistically significant difference between the two groups regarding neurological involvement and speech characteristics. Correlation analysis indicated differences in speech articulation in relation to staging and axial scores of rigidity and bradykinesia for middle and late-onset. Conclusions Impairment of speech articulation did not correlate with age at onset of disease, but was positively related with disease duration and higher scores ...