original ) (raw )Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases
Francesco Amadei
Journal of medicinal chemistry, 2017
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CDP840. A prototype of a novel class of orally active anti-Inflammatory phosphodiesterase 4 inhibitors
Richard Taylor
Bioorganic & Medicinal Chemistry Letters, 2002
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Novel N-indolylmethyl substituted olanzapine derivatives: Their design, synthesis and evaluation as PDE4B inhibitors
Ankit Jain
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Novel 1-alkynyl substituted 1,2-dihydroquinoline derivatives from nimesulide (and their 2-oxo analogues): A new strategy to identify inhibitors of PDE4B
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Bioorganic & Medicinal Chemistry Letters, 2011
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Pharmacology ofN-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline Carboxamide (SCH 351591), a Novel, Orally Active Phosphodiesterase 4 Inhibitor
John Hey
Journal of Pharmacology and Experimental Therapeutics, 2002
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CHF6001 I: A Novel Highly Potent and Selective Phosphodiesterase 4 Inhibitor with Robust Anti-Inflammatory Activity and Suitable for Topical Pulmonary Administration
Emilio Hirsch
The Journal of pharmacology and experimental therapeutics, 2015
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7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma
Richard Davenport
Bioorganic & Medicinal Chemistry Letters, 2002
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Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
Marco Aurélio Martins
Memórias do Instituto Oswaldo Cruz, 2005
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Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site
Maria Giovannoni
Naunyn-Schmiedeberg's Archives of Pharmacology, 2002
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Pharmacology ofN -(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline Carboxamide (SCH 351591), a Novel, Orally Active Phosphodiesterase 4 Inhibitor
motasim billah
Journal of Pharmacology and Experimental Therapeutics, 2002
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Phosphodiesterase 4 Inhibitors for the Treatment of COPD
a ab
Chest, 2002
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PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes
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International Journal of Molecular Sciences
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2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors
Joseph Bruno
Bioorganic & Medicinal Chemistry Letters, 1998
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The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4
M. Holbrook
British Journal of Pharmacology, 1996
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Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future
Mauro Martins
Trends in Pharmacological Sciences, 1997
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Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors
Menghang Xia , Adrián Turjanski , Ruili Huang
Bioorganic & Medicinal Chemistry Letters, 2009
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Synthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 Inhibitors
Marco Aurélio Martins
PloS one, 2016
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9-Benzyladenines: Potent and Selective cAMP Phosphodiesterase Inhibitors
C. Lugnier
Journal of Medicinal Chemistry, 1997
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New Avenues for Phosphodiesterase Inhibitors in Asthma
Josuel Ora
Journal of Experimental Pharmacology
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Quinazolines: Combined type 3 and 4 phosphodiesterase inhibitors
Reto Naef
Bioorganic & Medicinal Chemistry Letters, 1998
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Advances in the Development of Phosphodiesterase-4 Inhibitors
Hengming Ke
Journal of Medicinal Chemistry, 2020
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kNN-MFA-guided 3D-QSAR on Some PDE4 Inhibitors of Benzylamine derivatives For Chronic Obstructive Pulmonary Disease
sushil kashaw
Indian Journal of Pharmaceutical Sciences, 2019
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Cyclic nucleotide phosphodiesterase type 4 inhibitors: Evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere
Philippe Bernard
European Journal of Medicinal Chemistry, 2008
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Identification of a potent new chemotype for the selective inhibition of PDE4
Amanda Skoumbourdis , Noel Southall
Bioorganic & Medicinal Chemistry Letters, 2008
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Identifying the structural features of pyrazolo[4,3-c]quinoline-3-ones as inhibitors of phosphodiesterase 4: An exploratory CoMFA and CoMSIA study
Current Enzyme Inhibition
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Synthesis and evaluation of analgesic, anti-asthmatic activity of (E)-1-(8-hydroxyquinolin-7-yl)-3-phenylprop-2-en-1 ones
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Arabian Journal of Chemistry, 2016
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Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2- a ]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors
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Journal of Medicinal Chemistry, 2000
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