Amlexanox in treatment of aphthous ulcers: A systematic review T.N. Uma Maheswari , P. Shanmugasundaram (original) (raw)
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Amlexanox in treatment of Aphthous ulcers-A Systematic review Umamaheswari T.N, Shanmugasundaram P
Journal of Pharmacy Research 01/2013; 6(1):214-7. · 2.60 Impact Factor, 2013
Aphthous ulcers (Canker sores) are recurrent multiple ulcers occurring in oral mucosa mainly in the buccal mucosa, labial mucosa, floor of the mouth and tongue. The etiology for aphthous is still not clear though many predisposing factors like stress, trauma, immunologically mediated, infectious agents like virus etc., are considered. As the etiopathogenesis of the disease is multifactorial, treatment mainly aims in symptomatic management of pain or burning sensation using mainly topical anesthetics or antiseptics. To facilitate the healing process, various anti-inflammatory and anti-allergic agents are also tried. A medication which could help in reduction of pain, ulcer size, erythema, ulcer duration and prevent recurrence is essential to treat the ulcers. The efficacy of Amlexanox in treatment of aphthous ulcers is tried in various clinical trials. This systematic review article aims in evaluation of Amlexanox efficacy in satisfying all the demands such as reduction of pain, ulcer size, ulcer duration erythema and recurrence.
International Journal of Contemporary Medical Research [IJCMR]
Introduction: Recurrent aphthous stomatitis (RAS) is a common condition of the mucosa of oral cavity characterized by recurrent attacks of small, round or oval, painful affecting 5-25% of the general population and rarely involves genital region. These lesions occur most commonly on the nonkeratinized epithelium of oral cavity and ulcers heal within a period of 10-14 days with characteristic feature of pain causing difficulty on chewing, swallowing, and/or speaking. So, the purpose of present study was to evaluate the effectiveness of Amlexanox 5% and Triamcinolone 0.1% for the treatment of recurrent aphthous ulcers. Material and Methods: This double-blinded randomized clinical study done in the Department of Oral Medicine And Radiology, Government dental college Srinagar includes 36 patients suffering from recurrent aphthous ulcers aged between 25 and 55 years old and, having minor aphthous ulcers not more than 48 hours old. Group-1 was administered with Triamcinolone 0.1% (Kenocort 0.1% oral paste, Abbort Laboratories Chicago USA), while the group-2 was administered with Amlexanox 5% (Lexanox 5% oral paste, macleods Pharmaceuticals India). The patients used these pastes four times daily for 7 days. The patients were followed at days 0, 3, 5 and 7 and scores were assessed using visual analog scale.
Cureus
Background Recurrent aphthous ulcers are one of the most common lesions of the oral mucosa. Most currently available treatment methods aim to relieve symptoms, speed up healing and prevent ulcer recurrence. The current study aimed to compare the effectiveness of Aloe vera gel with that of amlexanox 5% oral paste in the treatment of recurrent small-type aphthous ulcers. Materials and Methods The study was conducted on 60 patients (27 males and 33 females) attending the Department of Oral Medicine at the Faculty of Dentistry at Damascus University. The sample age ranged between 15 to 25 years, with an average age of 20.3 ± 2.4 years. Patients were diagnosed with recurrent aphthous ulcers of the small type. The sample was divided into three groups with equal numbers of patients (n=20 for each group) according to the provided drug: Aloe vera, amlexanox, and the placebo groups. Patients' ulcer size was measured on day 0 of treatment, and the ulcer size reduction was assessed on day 3 and day 5. The pain was also recorded at the first visit, and then pain reduction was assessed during follow-up visits. Results The mean ulcer size on the fifth day of treatment was 1.85 mm 2 , 4.05 mm 2 , and 6.20 mm 2 in the Aloe vera, the amlexanox, and the placebo groups, respectively. The differences between groups were significant (p=0.003). The mean pain on the fifth day was 0.80 cm, 1.60 cm, and 3.20 cm in the Aloe vera, the amlexanox, and the placebo groups, respectively. The differences between groups were significant (p=0.026). Conclusions Within the limits of the current trial, both treatment groups proved effective in accelerating ulcer healing with the superiority of Aloe vera compared to amlexanox, as it achieved a greater reduction in ulcer size and pain when assessed on the fifth day of treatment.
BMC Oral Health, 2016
Background: Recurrent Aphthous stomatitis (RAS) is a prevalent ulcerative and painful disorder of the oral cavity with unknown etiology and for which no efficient treatment is currently available. The present study aimed to evaluate the safety and the efficacy of AphtoFix®, a new mouth ulcer cream that was developed to help treat RAS. Prior to launching the product on the market, two initial safety assessment studies were performed. Subjects and methods: In a first study, the in vitro biocompatibility of AphtoFix® was evaluated on reconstructed human gingival tissue models according to ISO guidelines 10993. In a second study, the tolerability of AphtoFix® was evaluated in 20 subjects during a 4-weeks daily application in the mouth. The third study investigated both the safety and efficacy of AphtoFix® treatment on 19 patients suffering from RAS. This study was done in compliance with the Helsinki Declaration. Results: The results of in vitro biocompatibility study showed that AphtoFix® mouth ulcer cream did not induce any detectable cytotoxicity and irritation. These observations were confirmed in the 4 weeks tolerability study where no undesired of adverse reactions were noticed. The results of the post-market clinical efficacy study demonstrated a clear reduction in ulcer size from baseline after 3 days treatment (p < 0.05). Pain intensity reduction was also observed in all subjects. Conclusion: The application of AphtoFix® did not induce any undesired skin or mucosa reactions. These initial findings demonstrate that AphtoFix® is safe and efficient in reducing ulcer size and decreasing the pain intensity induced by ulcers.
International Journal of Preventive and Clinical Dental Research
Background: Although there are many drugs which are used for topical therapy in recurrent aphthous stomatitis (RAS) patients, there are few clinical trials that have used tetracycline and amlexanox. Aim and Objectives: To evaluated the therapeutic efficacy of topical tetracycline and amlexanox. Materials and Methods: Here in this study we divided the RAS patients into two groups in each group alternative selection was done. Patients of 1st Group received topical application of tetracycline crushed tablets with denture adhesive and few drops of saline solution on each alternative day visit. Same as Group 2nd subject received amlexanox. Treatment response was assessed by measuring pain reduction, photographic record, ulcer duration, and adhesive retention time. Results: Amlexanox oral paste show more efficacy in comparision of topical tetracycline in the treatment of recurrent minor aphthous ulcers. Conculsion: Amlexanox is more effective in comparison of tetracycline.
International Journal of Pharmaceutical Investigation, 2021
Background: Aphthous stomatitis is a painful and often inflammatory condition. Objective of the study is to evaluate safety and efficacy of Arimu mouth ulcer gel (AHPL/ AYTOP/2014A) in subjects suffering from aphthous ulcers. Methods: This study compared effect of Arimu mouth ulcer gel (Group I), with sponsors other mouth ulcer gels (Group II, Group III), marketed Ayurvedic formulation (Group IV), and conventional preparation (Group V). Subjects were advised to apply given formulations twice daily for 14 days or till complete healing of ulcer whichever was earlier. Results: A total of 276 subjects completed the study. Statistically significant reduction in the mean pain score (VAS) was observed from first follow up visit and continued till the end of the study in all the groups. If compared, the reduction in the mean pain score was significantly more in Group I than Group II, Group III and Group IV and comparable to that of Group V on Day 3. On other follow up visits, change was comparable between the groups and the difference was not significant. The same trend had been observed for burning sensation. Onset of action was less and duration of action was longer in group I compared to other groups. The number of days required to heal ulcer was less in group I than other groups. Adverse events such as vomiting and fever occurred which were not related to study drugs and did not require discontinuation of the study treatment. Conclusion: Arimu mouth ulcer gel is safe and effective in treating aphthous ulcer.
Journal of Dental Research, Dental Clinics, Dental Prospects, 2021
Background. The present study aimed to assess and compare the pain perception and ulcer sizes before and after applying low-level laser therapy (LLLT) and Amlexanox + lidocaine. Methods. Twenty-six patients referring to the out-patient department of the institution and diagnosed with recurrent aphthous ulcers (RAU) were assigned to two groups to receive either LLLT or Amlexanox + lidocaine. In group 1, the patients were provided with amlexanox + lidocaine to apply topically four times daily. In group 2, the patients underwent LLLT with no tissue contact in inward circular motions for two cycles for 30 seconds. This study was registered in "the Clinical Trials Registry- India" (CTRI), with the registration number CTRI/2019/09/028222. The data were analyzed with SPSS 16. Results. The intergroup comparison was performed using Mann-Whitney U test, and intragroup comparisons were made using Wilcoxon’s signed-rank test. The level of significance was set at P <0.05. The result...
Recurrent Aphthous Ulcers: A Review of Diagnosis and Treatment
The Journal of the American Dental Association, 1996
RAU-also called canker soresare among the oral mucosal conditions that dentists and physicians see most commonly in their patients. Several systemic conditions are associated with oral aphthouslike ulcers, and aphthae themselves often are mistaken for recrudescent oral herpes simplex virus, or HSV, infections. This article will review RAU, describe systemic conditions associated with aphthouslike ulcerations and discuss the differences between RAU and recrudescent oral HSV Infections.
Balkan Journal of Dental Medicine, 2014
The aim of this study was to evaluate the effectiveness of a new medicinal plant extract (Ankaferd Blood Stopper®, ABS) on the healing process of aphthous ulcers. A total of 50 patients with recurrent aphthous stomatitis (RAS) who have had currently a single oral ulcer in the mouth were included in the study. Patients were randomly divided in 2 groups: ABS group and Kenacort group (triamcinolone acetonid). Data were collected by questionnaire regarding age, gender, RAS history including the number of ulcer episodes in 1 month, the number of ulcers in each episode, mean healing time of previous ulcers and the mean disease duration. Ulcer size, ulcer related pain, evaluated by VAS and effectiveness index (EI), was noted in each clinical examination.In the present study, no significant differences were seen in demographic and RAS related data between the 2 groups. In ABS and Kenacort group, the mean ulcer size and VAS scores were statistically reduced at day 3 and day 7 compared to bas...