High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors (original) (raw)

Two Restricted Sites on the Surface of the Nerve Growth Factor Molecule Independently Determine Specific TrkA Receptor Binding and Activation

Ted Ebendal

Journal of Biological Chemistry, 1997

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The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin

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The EMBO journal, 1994

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trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

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The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site

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The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

Jose Ramirez

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The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

Shuqian Jing

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Down-regulation of the Neurotrophin Receptor TrkB following Ligand Binding. EVIDENCE FOR AN INVOLVEMENT OF THE PROTEASOME AND DIFFERENTIAL REGULATION OF TrkA AND TrkB

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Journal of Biological Chemistry, 2000

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Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC

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The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

Shuqian Jing

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Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB

Rainer Schneider

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An immunoglobulin-like domain determines the specificity of neurotrophin receptors

Pantelis Tsoulfas

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The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

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Direct interaction of nerve growth factor receptor, TrkA, with non‐receptor tyrosine kinase, c‐Abl, through the activation loop

Monica Ștefan

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TrkA cross-linking mimics neuronal responses to nerve growth factor

Louis Reichardt, G. Weskamp

1994

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Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system

Richard Smeyne

The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994

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Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3

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The trkA receptor mediates growth cone turning toward a localized source of nerve growth factor

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The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997

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Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

David Goeddel

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TrkA receptor mediates growth cone turning toward a localized source of nerve growth factor

Paul Letourneau

The Journal of Neuroscience : The Official Journal of the Society for Neuroscience

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Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo

Frédéric Marmigère

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Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells

Annakaisa Haapasalo

Oncogene, 1999

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Identification of a Switch in Neurotrophin Signaling by Selective Tyrosine Phosphorylation

Juan Mesias Chaupez Arevalo

Journal of Biological Chemistry, 2005

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Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling

Fernette Eide

1996

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Role of variable beta-hairpin loop in determining biological specificities in neurotrophin family

Bruna Duquia

Journal of Biological Chemistry, 1994

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A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor-Dependent Cell Survival but Not Neurite Outgrowth

Ela Gryz

Journal of Neurochemistry, 2002

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Regulation of neurotrophin receptor expression during embryonic and postnatal development

Sean Wyatt

The Journal of …, 1994

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