Direct interaction of nerve growth factor receptor, TrkA, with non‐receptor tyrosine kinase, c‐Abl, through the activation loop (original) (raw)
Direct Binding of the Signaling Adapter Protein Grb2 to the Activation Loop Tyrosines on the Nerve Growth Factor Receptor Tyrosine Kinase, TrkA
Susan Meakin, Ela Gryz
Journal of Biological Chemistry, 2000
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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.
David Loeb
Oncogene, 1998
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The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor, TrkA
Susan Meakin
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Two Restricted Sites on the Surface of the Nerve Growth Factor Molecule Independently Determine Specific TrkA Receptor Binding and Activation
Ted Ebendal
Journal of Biological Chemistry, 1997
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Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation
Susan Meakin, Ela Gryz
Oncogene, 2000
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Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway
Thangiah Geetha
Molecular and Cellular Biology, 2001
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Tyrosine 785 is a major determinant of Trk--substrate interaction
J. Schlessinger
The EMBO journal, 1993
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The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
Shuqian Jing
Cell, 1991
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High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors
Pantelis Tsoulfas
Journal of Biological Chemistry, 1998
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A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor-Dependent Cell Survival but Not Neurite Outgrowth
Ela Gryz
Journal of Neurochemistry, 2002
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Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases
Michael Demarco
Cell, 1992
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NGF stimulation of erk phosphorylation is impaired by a point mutation in the transmembrane domain of trkA receptor
Philip Lazarovici
Journal of Molecular Neuroscience - J MOL NEUROSCI, 2000
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TrkA cross-linking mimics neuronal responses to nerve growth factor
Louis Reichardt, G. Weskamp
1994
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A Purine Analog‐Sensitive Protein Kinase Activity Associates with Trk Nerve Growth Factor Receptors
David Loeb
Journal of neurochemistry, 1993
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δ-Protein Kinase C Phosphorylation Parallels Inhibition of Nerve Growth Factor– Induced Differentiation Independent of Changes in Trk A and MAP Kinase Signalling in PC12 Cells
jari heikkila
Cellular Signalling, 1998
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The Cytoplasmic and Transmembrane Domains of the p75 and Trk A Receptors Regulate High Affinity Binding to Nerve Growth Factor
Diego Esposito
Journal of Biological Chemistry, 2001
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Identification and Structure of the Nerve Growth Factor Binding Site on TrkA
Shelley Allen
Biochemical and Biophysical Research Communications, 2001
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A Signaling Organelle Containing the Nerve Growth Factor-Activated Receptor Tyrosine Kinase, TrkA
William Mobley
Proceedings of the …, 1997
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Autocrine regulation of nerve growth factor expression by Trk receptors
Alessandra Mallei
Journal of Neurochemistry, 2004
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Nerve growth factor activates kinases that phosphorylate atypical protein kinase C
Lamar Seibenhener
Cellular Signalling, 2002
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A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth
Armin Blesch
Journal of Neuroscience Research, 2009
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Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKM
Joanne Kays
Journal of Neurophysiology, 2012
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Acidic substitution of the activation loop tyrosines in TrkA support nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human neuroblastoma cell line, SY5Y
Susan Meakin
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The Cyclic Adenosine Monophosphate-dependent Protein Kinase (PKA) Is Required for the Sustained Activation of Mitogen-activated Kinases and Gene Expression by Nerve Growth Factor
Hong Yao
Journal of Biological Chemistry, 1998
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TrkA Tyrosine Residues Involved in NGF-induced Neurite Outgrowth of PC12 Cells
Dan Lindholm
European Journal of Neuroscience, 1995
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Lysine 63 Polyubiquitination of the Nerve Growth Factor Receptor TrkA Directs Internalization and Signaling
Thangiah Geetha
Molecular Cell, 2005
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Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3
Susan Meakin
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
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TrkC Isoforms with Inserts in the Kinase Domain Show Impaired Signaling Responses
Pantelis Tsoulfas
Journal of Biological Chemistry, 1996
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Association of the Atypical Protein Kinase C-interacting Protein p62/ZIP with Nerve Growth Factor Receptor TrkA Regulates Receptor Trafficking and Erk5 Signaling
Thangiah Geetha
Journal of Biological Chemistry, 2003
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Phospholipase C-γ and Phosphoinositide 3Kinase Mediate Cytoplasmic Signaling in Nerve Growth Cone Guidance
Benedikt Berninger
Neuron, 1999
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The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells
Hava Avraham
Journal of Biological Chemistry, 1999
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Mapping of Atypical Protein Kinase C within the Nerve Growth Factor Signaling Cascade: Relationship to Differentiation and Survival of PC12 Cells
Lamar Seibenhener
Molecular and Cellular Biology, 2000
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Identification of a Switch in Neurotrophin Signaling by Selective Tyrosine Phosphorylation
Daniela - Pereira
Journal of Biological Chemistry, 2006
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Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation
Delio Mercanti
Proceedings of the National Academy of Sciences, 2009
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Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells
Garrett Brodeur
Oncogene, 2000
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