Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats (original) (raw)
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BIOCHEMICAL STUDY ON THE EFFICACY OF MALAYSIAN HONEY ON INFLICTED WOUNDS: AN ANIMAL MODEL
: The efficacy of Malaysian honey on the healing of wounds in Sprague-Dawley rats was investigated on the basis of biophysical and biochemical changes. Equidimensional full-thickness excision wounds were created on the back of each animal and treated either by topical application or by a combination of topical and oral administration of honey. Control animals received only saline. Development of wound healing was evaluated by measuring the rates of wound contraction and epithelialization. Quantitative assays were performed to determine the amounts of uronic acid, hexosamine, DNA, and collagen content of the granulating tissues. The serum albumin level was also measured. The results obtained showed that honey accelerates wound healing by influencing cell division and proliferation, collagen synthesis and maturation, wound contraction and epithelializa-tion. All the parameters measured showed remarkable consistency with the wound healing property of honey. Honey also improved the nutritional state of the animal when given orally.
2013
Point-by-point responses to the reviewer's comments on the manuscript "Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats" The authors would like to thank Reviewers for careful review of our manuscript and providing us with their comments and suggestion to improve the quality of the manuscript. The following responses have been prepared to address all of the reviewers' comments in a point-by-point fashion. Reviewer 1 (Aliyu Muhammad) First of all, authors would like to thank Reviewer 1 for the considering our manuscript interesting and accepting it for publication after this revision. We have incorporated the following reviewer's specific comments in preparation of revised version of manuscript. Minor Comments Comment Comments and response 1 "The write-up is characterized by some grammatical/typo errors that need to be urgently addressed. For instance, "therefore" is repeatedly mentioned in the last two sentence of the background section of the abstract etc." Agreed: Grammatical/typo errors and text revised as per suggestions. 2 "Like in Tables 2 and 3 the statistical signs were not well assigned within and outside the tables" Agreed: The statistical signs revised as per suggestion. Please refer to the tables at pages 18-19. 3 "There were no arrows to indicate the histopathological observations on the photomicrographs/plates."
Effects of Mad Honey on Some Biochemical Parameters in Rats
Journal of evidence-based complementary & alternative medicine, 2015
The aims of this study were to determine grayanotoxin (GTX-III) toxin level in mad honey using liquid chromatography-tandem mass spectrometry and examine the dynamic changes of certain biochemical parameters in blood serum of rats that consumed mad honey. For the experimental animal study, 20 Sprague-Dawley female rats were divided into 5 groups of 4 rats each, with one group being the control group (Group 1) and the others being the experimental groups (Groups 2-5). Groups 2, 3, 4, and 5 were, respectively, given mad honey extract at doses of 0.3, 0.6, 1.2, and 2.4 mg/g body weight/day via oral gavage for 8 days. According to results, the quantity of GTX-III found in the honey sample as 39.949 ± 0.020 μg GTX-III/g honey, and the biochemical analysis of the tested parameters (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase, creatine kinase, and creatine kinase muscle and brain) showed a significant elevation with increasing concentra...
Effects of Acacia Honey on Wound Healing in Various Rat Models
Honey is a traditional remedy for the treatment of infected wounds, and is becoming more important as microbial resistance to conventional therapeutic agents increases. A study was conducted to assess the wound-healing activity of Acacia honey using incision, excision, burn and dead-space wound models in rats. Different formulations of honey were used and rats were treated topically as well as orally. Both the higher and lower doses of honey produced a signifi cant effect on healing (p < 0.05). The area of epithelization was found to increase, followed by an increase in wound contraction, skin-breaking strength, tissue granulation. The hydroxyproline content also increased in the rats treated with higher doses of honey compared to control, indicating an increase in collagen formation.
Daily consumption of honey: effects on male Wister albino rats
2012
This study was primarily designed to investigate the effect of acute administration of honey on the biochemical parameters on male Wister albino rats. Fifteen male rats were divide into five groups of three each and were administered with distilled water, 10%, 20%, 50%, and 100% (v/v) of pure honey daily for seven days in that order. On the eighth day the rats were humanly sacrificed and blood samples were collected for analyses. Diastase activity and hydroxylmethylfurfural level were determined from the honey. Serum protein, albumin, globulin, glucose, urea, creatinine, alkaline phosphatase, alanine aminotransferase, total cholesterol, HDL, LDL, VLDL and complete blood counts were determined by automatic analyzer. Diastase activity and hydroxylmethylfurfural level were below the imposed limits. Significant (p < 0.05) increased in body weight was observed as the administration progressed days except on 1st and 2nd days at 20% (v/v). Also within the treatment group, the body weight increased in a concentration dependent manner from 10% to 20% but started decreasing from 50% to 100% (v/v). Significant (p < 0.05) decrease in creatinine level was observed from 20% to 100% (v/v). ALP and ALT activities dropped at 100% (v/v). However, significant (p < 0.05) decrease in triglyceride and VLDL were observed with simultaneous significant (p < 0.05) increase in packed cell volume, mean corpuscular hemoglobin and white blood cell counts at 20% (v/v) treated Int.