Clinical Characteristics and Management of Patients with Gastric Precancerous Lesions (GPL) in France: A Large 15-YEARS Single Center Retrospective Study (original) (raw)
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Journal of Drugs in Dermatology
are both first authors Background: While rosacea is a common inflammatory condition that affects diverse populations, published data in skin of color (SOC) are limited. This review explored nuances in clinical presentation and treatment considerations in SOC patients with rosacea and the role of cleansers and moisturizers in the management of rosacea in these populations. Methods: A panel reviewed and discussed aspects of rosacea in SOC and possible implications for treatment and maintenance. The outcome of these discussions, coupled with the panel's expert opinion and experience was used to define draft statements. After group discussions and an online review process, the panel agreed on the inclusion and wording of five statements. Results: Studies and anecdotal clinical experience suggest that rosacea is more common in SOC populations than previously reported. The clinical presentation of rosacea across diverse skin types includes the spectrum of clinical subtypes observed in other populations; however, clinical features may be less conspicuous in individuals with higher skin phototypes and the index of suspicion may be lower in SOC populations. To avoid underdiagnosis, dermatologists should consider rosacea in the differential diagnosis of any patient presenting with a history of skin sensitivity, central facial erythema, papules, and pustules. The compromised barrier in rosacea contributes to skin sensitivity. Studies including Chinese rosacea patients showed that using a moisturizer and sunscreen negatively correlated with rosacea development. Conclusions: The use of skincare could improve rosacea symptomatology. These products are recommended before and during prescription therapy and as part of a maintenance regimen as adjuncts.
Rosacea and Chronic Systemic Diseases: Case-ControlStudy in Saudi Arabia
2020
Objective: We sought to examine the association between rosacea and systemic comorbidities in patients attending the dermatology clinic at King Fahd Hospital of the University in Al-Khobar during a 14-month period (February 2016 to May 2017). Methods: This was a prospective single-center case-control study conducted in the dermatology department of King Fahd Hospital of the University (KFHU) during a 14-month period. Self-administered questionnaires were distributed to rosacea patients and controls. The questionnaires examined demographic data, current comorbidities, family histories, and lifestyles. Study limitations were report and recall biases, which are major limitations of self-reported questionnaires. Results: A total of 76 patients (38 cases and 38 controls) of Arabic origin were recruited in the study. The mean age was 33.2 years for the cases and 27.4 years for the controls. Positive p values were seen in family histories of rosacea, photosensitivity, and food allergies. H...
Journal of Dermatological Treatment
Objective: To characterize rosacea features suitable for identification of high-burden (HB) subjects in clinical practice. Design: Global online survey with subjects recruited using an online panel from the United States, Canada, Italy, United Kingdom, Germany and France. Subjects self-reported a physician's diagnosis of rosacea. Measurements: HB subjects were defined as those with !3/4 domains (quality of life, lifestyle adaptation, time trade-off, willingness to pay) greater than the median. Group characteristics were analyzed and multivariate-logistic modeling used to investigate factors most associated with HB. Results: 710 subjects completed the survey, including 158 HB subjects. HB was observed in all selfdeclared rosacea severities. HB subjects were more likely to spend more time daily on skin care and experienced approximately double the impact of health problems on work productivity in the past 7 days (p < .01). In the past 12 months, HB subjects were more likely to have at least one visit to the emergency room (41.8% vs 11.2%; p < .01). In the multivariate risk analysis, factors most associated with HB included rosacea severity, impact of health problems on regular daily activities and age at first symptoms. Conclusion: Rosacea has a distinct subset of HB subjects who can be successfully characterized.
Risk factors associated with rosacea
Journal of the European Academy of Dermatology and Venereology, 2010
Background Although rosacea is a common disease, the cause of disease is still a mystery -Helicobacter pylori infection, genetic predisposition, climatic factors, and detrimental habits are implicated as triggers of rosacea.
Journal of Translational Medicine and Research, 2016
Objectives: Rosacea is currently defined as an inflammatory cutaneous disease without systemic echoes. The objective of our paper is to review the published articles to confirm our belief that rosacea is associated to or can predispose to various diseases, mainly inflammatory diseases. Material and methods: Review all the papers published in the last two decades in PubMed, Google Academic and Medscape databases, linking rosacea and various disorders of the body systems. Results: We found that rosacea is associated to several illnesses of major systems (gastrointestinal, cardiovascular, respiratory) and that there are also links between rosacea and immune system disorders and psychiatric diseases. Rosacea clinical course can be influenced by various drugs prescribed for the previous mentioned diseases. Conclusions: Rosacea should no longer be considered a localized cutaneous condition but rather a complex pathology with systemic reverberation. Patients suffering of severe forms of rosacea for a long period of time should have a careful evaluation of body systems.
BACKGROUND: Rosacea is currently diagnosed by consensus-defined primary and secondary features and managed by subtype. However, individual features (phenotypes) can span multiple subtypes, which has implications for clinical practice and research. Adopting a phenotype-led approach may facilitate patient-centred management. OBJECTIVES: To advance clinical practice by obtaining international consensus to establish a phenotype-led rosacea diagnosis and classification scheme with global representation. METHODS: Seventeen dermatologists and three ophthalmologists used a modified Delphi approach to reach consensus on statements pertaining to critical aspects of rosacea diagnosis, classification and severity evaluation. All voting was electronic and blinded. RESULTS: Consensus was achieved for transitioning to a phenotype-based approach to rosacea diagnosis and classification. Two features were independently considered diagnostic for rosacea: persistent, centrofacial erythema associated with periodic intensification; and phymatous changes. Flushing, telangiectasia, inflammatory lesions and ocular manifestations were not considered individually diagnostic. The panel reached agreement on dimensions for phenotype severity measures and established the importance of assessing the patient burden of rosacea. CONCLUSIONS: The panel recommended an approach for diagnosis and classification of rosacea based on disease phenotype. This article is protected by copyright. All rights reserved.
Archives of Clinical & Experimental Dermatology, 2020
Rosacea is a chronic inflammatory cutaneous condition, characterized by facial redness in the first stages, followed by papules, pustules and deformities later on the course. The pathogenesis of the disease involves several factors, such as immunologic, infectious and environmental triggers. Genetic predisposing factors are also postulated due to the remarkably positive family history often found. Through a detailed literature review, we aim to qualify and quantify the impact of climatic versus genetic factors on rosacea epidemiology worldwide. Possible associations are here considered, including the higher prevalence of rosacea in fair-skinned individuals of Northern European descent, the influence of the latitude, cold weather, and the diagnostic inaccuracy in people with skin of color. Further, we discuss the roles of cold-induced vasodilation, the skin colonization by Demodex mites, and the findings from the most recent genetic studies in this field.
Prevalence of rosacea in the general population of Germany and Russia - The RISE study
Journal of the European Academy of Dermatology and Venereology : JEADV, 2016
There is an unmet need for general population-based epidemiological data on rosacea based on contemporary diagnostic criteria and validated population survey methodology. To evaluate the prevalence of rosacea in the general population of Germany and Russia. General population screening was conducted in 9-10 cities per country to ensure adequate geographic representation. In Part I of this two-phase study, screening of a representative sample of the general population (every fifth person or every fifth door using a fixed-step procedure on a random route sample) was expedited with use of a questionnaire and algorithm based on current diagnostic criteria for rosacea. Of the subjects that screened positive in the initial phase, a randomly selected sample (every third subject) t`hen underwent diagnostic confirmation by a dermatologist in Part II. A total of 3052 and 3013 subjects (aged 18-65 years) were screened in Germany and Russia respectively. Rosacea prevalence was 12.3% [95%CI, 10....
Br J Dermatol , 2020
Background A transition from a subtyping to a phenotyping approach in rosacea is underway, allowing individual patient management according to presenting features instead of categorization by predefined subtypes. The ROSacea COnsensus (ROSCO) 2017 recommendations further support this transition and align with guidance from other working groups. Objectives To update and extend previous global ROSCO recommendations in line with the latest research and continue supporting uptake of the phenotype approach in rosacea through clinical tool development. Methods Nineteen dermatologists and two ophthalmologists used a modified Delphi approach to reach consensus on statements pertaining to critical aspects of rosacea diagnosis, classification and man agement. Voting was electronic and blinded. Results Delphi statement s on which the panel achieved consensus of ≥ 75% voting ‘Agree’ or ‘Strongly agree’ are presented. The panel recommends discussing disease burden with patients during consultations, using four questions to assist conversations. The primary treatment objective should be achievement of complete clearance, owing to previously established clinical benefits for patients. Cutaneous and ocular feat ures are defined. Treatments have been reassessed in line with recent evidence and the prior treatment algorithm updated. Combination therapy is recommended to benefit patients with multiple features. Ongoing monitoring and dialogue should take place between physician and patients, covering defined factors to maximize outcomes. A prototype clinical tool (Rosacea Tracker) and patient case studies have been developed from consensus statements. Conclusions The current survey updates previous recommendations as a basis for local guideline development and provides clinical too ls to facilitate a phenotype approach in practice and improve rosacea patient management.