Clinica Chimica Acta 332 (2003) 23–30 (original) (raw)
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Plasma homocysteine and its relationships with atherothrombotic markers in psoriatic patients
Clinica Chimica Acta, 2003
Background: Hyperhomocysteinemia may constitute an independent risk factor for cardiovascular disease and may promote atherothrombosis. Psoriasis is one of the diseases associated with increased atherothrombosis. The aim of the present study was to examine serum total homocysteine (tHcy) level and its relationships with atherothrombotic markers. Methods: The study group included 30 patients with psoriasis (17 females and 13 males) with a mean age of 34.2 (age range: 27 -40) and 30 sex and age matched healthy volunteers (15 females and 15 males) with a mean age of 36.7 (age range: 26 -48). The concentrations of lipids, lipoproteins, acute phase reactants, tHcy and atherothrombotic markers [fibronectin, soluble vascular adhesion molecules-1 (sVCAM-1), soluble intercellular adhesion molecules-1 (sICAM-1), tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), autoantibodies against oxidized LDL (AuAb-oxLDL)] were determined. Results: The mean levels of serum tHcy, fibrinogen, fibronectin, sICAM, PAI-1 and AuAb-oxLDL were increased in patients whereas tPA, vitamin B 12 and folate levels were decreased significantly. Increased levels of sVCAM were not statistically significant. tHcy levels were negatively correlated with vitamin B 12 (r = À 0.40, P = 0.027) and positively correlated with PAI-1 and AuAb-oxLDL levels (r = 0.46, P = 0.011; r = 0.39, P = 0.035, respectively). Conclusions: It was concluded that the increased homocysteine concentration and altered endothelial cell-mediated proteins associated with increased lipids and LDL oxidation may play an important role for the development of atherothrombotic complications with psoriasis. D
Plasma homocysteine levels in patients with Psoriasis
Asian Journal of Medical Sciences
Background: Hyper homocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. Aims and Objective: The aim of this study is to investigate homocysteine in psoriatic patients and its relationship with the severity of the disease. Materials and Methods: A case control study in 50 patients with chronic plaque psoriasis and 50 healthy controls was performed. Total plasma homocysteine level, and PASI index were assessed in every patient. Results: Patients with psoriasis had plasma homocysteine levels higher than controls. The severity of psoriasis assessed according to PASI directly correlate either with plasma homocysteine. Conclusion: A significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. Our data directly correlate the high level of homocysteine with higher PASI scores.
Homocysteine, vitamin B 12 and folic acid levels in psoriasis patients
Journal of The European Academy of Dermatology and Venereology, 2009
AbstractBackground Hyperhomocysteinaemia is a risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. An association between psoriasis and cardiovascular diseases has been reported.Aim The aim of our study was to examine serum homocysteine, folic acid and vitamin B12 levels in psoriasis patients.Material and methods We performed a cross-sectional study in 70 consecutive outpatients with chronic plaque psoriasis and 70 age- and gender-matched controls. Serum levels of homocysteine, vitamin B12 and folic acid levels were measured in both groups.Results Serum homocysteine, folic acid and vitamin B12 levels did not differ between patient and control groups. In psoriasis patients, homocysteine levels correlated directly with psoriasis severity as measured by psoriasis area and severity index. Serum homocysteine level inversely correlated with serum folic acid levels in the patient group.Discussion Homocysteine levels correlated with psoriasis area and severity index in the patient group, which shows the disease severity. The increase in cardiovascular mortality with the severity of psoriasis might be also due to the effects of homocysteine.Background Hyperhomocysteinaemia is a risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. An association between psoriasis and cardiovascular diseases has been reported.Aim The aim of our study was to examine serum homocysteine, folic acid and vitamin B12 levels in psoriasis patients.Material and methods We performed a cross-sectional study in 70 consecutive outpatients with chronic plaque psoriasis and 70 age- and gender-matched controls. Serum levels of homocysteine, vitamin B12 and folic acid levels were measured in both groups.Results Serum homocysteine, folic acid and vitamin B12 levels did not differ between patient and control groups. In psoriasis patients, homocysteine levels correlated directly with psoriasis severity as measured by psoriasis area and severity index. Serum homocysteine level inversely correlated with serum folic acid levels in the patient group.Discussion Homocysteine levels correlated with psoriasis area and severity index in the patient group, which shows the disease severity. The increase in cardiovascular mortality with the severity of psoriasis might be also due to the effects of homocysteine.Conflicts of interestNone declaredNone declared
Homocysteine plasma levels in psoriasis patients: our experience and review of the literature
Journal of the European Academy of Dermatology and Venereology : JEADV, 2015
People with psoriasis are at higher cardiovascular risk. Plasma levels of homocysteine over the normal range have been recognized as marker of cardiovascular risk. Psoriasis patients express higher levels of plasma homocysteine than healthy people. Our study aims to investigate the correlation between homocysteinaemia, severity and duration of psoriasis and psoriasis arthritis, and to evaluate the effect of a 12-week administration of a target therapy for psoriasis on homocysteinaemia. Fifty-two psoriasis patients (study group) submitted to different kind of therapy for psoriasis (biological, systemic not biological and topical) and 24 healthy Italian subject (control group) were evaluated for their plasmatic homocysteine levels, both at baseline (T0) and 12 weeks after they a specific therapy for psoriasis. A significant difference between the homocysteinaemia of psoriasis patients (mean 19.71 ± 11.16) and control group (13.90 ± 11.18), P < 0.05 (Fig. 1), was found at baseline (...
Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients
TURKDERM
Background and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population
Inflammation and hypercoagulable state in adult psoriatic men
Acta dermato-venereologica, 2008
Hyperhomocysteinaemia is a well-known risk factor for cardiovascular disease and plays a role in atherothrombosis. Psoriasis is a common chronic and recurrent inflammatory skin disease associated with increased thrombosis. The aim of this study was to examine serum homocysteine levels and their relationships with inflammatory and atherothrombotic markers in psoriasis. Twenty patients with mild or moderate psoriasis and 20 age-matched healthy men were included in this study. Patients with acquired hyperhomocysteinaemia were excluded from both groups. The inflammation markers, mean platelet volume, C-reactive protein and ceruloplasmin levels, were significantly increased in the study group compared with the control group. In the study group there was decreased antithrombin III and total homocysteine levels, for haemostatic parameters. Folic acid levels, cardiovascular risk factors, endothelial inflammation markers and blood coagulation factors demonstrated significant correlations. Fo...
Background: Psoriasis is a common chronic and recurrent inflammatory skin disease that can occur due to abnormalities in essential fatty acid metabolism, lymphokine secretion, free radical generation, lipid peroxidation and eicosanoid metabolism, and has been associated with increased frequency of cardiovascular events. The current study was designed to evaluate plasma lipids, susceptibility of LDL to oxidation and oxidant – antioxidant status and their relationships in patients with psoriasis. Methods: The study group included 35 patients with psoriasis (18 females and 17 males), and 35 sex- and age-matched healthy volunteers (16 females and 19 males). From blood samples, their lipids, lipoproteins, acute phase reactants, lipid peroxidation products [lipid hydroperoxide (LHP) and malondialdehyde (MDA)], antioxidant enzymes [glutathione peroxidase (GSH-Px), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT)], total antioxidant status (TAS) and autoantibodies against oxidized low-density lipoprotein (AuAb-oxLDL) levels were determined. Moreover, the susceptibility of copper-induced in vitro oxidation of LDL was examined. Results: The mean levels of atherogenic lipids (total cholesterol [TC], triacylglycerol [TG] and LDL cholesterol [LDL-C]), acute-phase reactants (CRP, ESR, PMNLs, ceruloplasmin and fibrinogen) and lipid peroxidation products, AuAb-oxLDL levels in patients with psoriasis were found to be significantly higher than those of healthy subjects. On the other hand, TAS and antioxidant enzyme activities (CAT, SOD and GSH-Px in erythrocyte and SOD in plasma) were significantly lower when compared to healthy subjects. The lag times [t(lag)], a measure of resistance to oxidation of LDL, were also lower. The levels of AuAb-oxLDL in patients were correlated with TC, LDL-C, plasma LHP, erythrocyte MDA, oxidized LDL-MDA (oxLDL-MDA), fibrinogen, CRP, PMNL levels and plasma SOD activities (r = 0.69, P < 0.01; r = 0.64, P < 0.01; r = 0.38, P < 0.05; r = 0.65, P < 0.01; r = 0.34, P < 0.05; r = 0.34, P < 0.05; r = 0.53, P < 0.01, r = 0.34, P < 0.05; r = 0.67, P < 0.01, respectively). On the other hand, t(lag) was correlated negatively with the levels of VLDL-TG, VLDL-TC and LDL-TG but positively correlated with the levels of TAS in psoriatics (r = 0.49, P < 0.01; r = 0.49, P < 0.01, r = 0.65, P < 0.05; r = 0.37, P < 0.05). Conclusions: It was concluded that the psoriatic patients could be considered as a group with an increased atherosclerotic risk because of increased oxidant stress, decreased antioxidant capacity and susceptibility in lipid profile and lipoprotein content to atherogenicity.
Serum Homocysteine, Folic Acid and Vitamin B12 Levels in Patients with Psoriasis Vulgaris
The Egyptian Journal of Hospital Medicine
Background: Psoriasis is a chronic inflammatory skin condition with increased risk of cardiovascular disease. Hyperhomocysteinaemia might account for the increased susceptibility to CV diseases in psoriasis patients. Homocysteine metabolism is dependent in part on folate and vitamin B12 so deficiency of these vitamins may lead to hyperhomocysteinaemia. Objective: This study aimed to investigate the association between homocysteine, folic acid and vitamin B12 levels and psoriasis vulgaris and to evaluate the correlation between homocysteine, folic acid and vitamin B12 levels and the severity of psoriasis vulgaris. Patients and methods: This case control study included 80 subjects who were distributed into two groups; Cases group (Group A): included 50 patients with chronic plaque psoriasis vulgaris, and Control group (Group B): included 30 non psoriatic healthy, age and sex matched, subjects. Results: The mean folic acid level in the psoriasis group was 3.69 (SD 0.96) nmol/l which was statistically significantly lower as compared with the control group (5.67 ± 1.31 nmol/l) (p< 0.001). The mean vitamin B12 level in the psoriasis group was 186.94 (SD 64.90) pmol/l which was statistically significantly lower as compared with the control group (353.73 ± 76.76 pmol/l) (p<0.001). The mean homocysteine level in the psoriasis group was 18.54 (SD 4.18) nmol/mL which was statistically significantly higher as compared with the control group (11.09 ± 1.78 nmol/mL) (p<0.001). Conclusion: hyperhomocysteinaemia, decreased serum folate levels, and decreased serum B12 levels are common in patients with psoriasis. Serum homocysteine level was negatively correlated with serum folate level. No significant correlation was found between psoriasis severity (as measured by psoriasis area and severity index) and serum levels of homocysteine, folic acid, or vitamin B12.
Our Dermatology Online, 2016
Introduction: Hyperhomocystienemia has emerged an independent risk factor for cardiovascular diseases with an implication for cardiovascular morbidity in psoriasis patients. Both vitamin B 12 and folic acid influence homocystiene metabolism as cofactors. Aim: To study the serum levels of homocystiene, vitamin B 12 and folic acid in patients with chronic plaque psoriasis and age matched controls. Methods: 55 males aged 22-66 years with chronic plaque psoriasis of 6 months to 20 years and 55 healthy male controls aged 20-65 years were studied. Results: Body surface area involvement was <10% in 38 (69%), between 10-20% in 10 (18.2%) and >20% in 7 (12.8%) patients, respectively. The PASI was <6 in 41 (74.5%), 6-12 in 10 (18.2%) and >12 in 4 (7.3%) patients, respectively. The serum homocystiene levels of >12 µmol/L were higher than normal (5-12 µmol/L) in all patients and 11 (22%) controls and the difference was statistically significant. The serum vitamin B 12 levels of <150 to 513pg/ml were on the lower side of the normal (174-878pg/ml) in all patients. The serum folic acid levels varied between 5.65 and >24ng/ml and elevated levels of 17.83 to >24ng/ml (normal 3-17 ng/ml) were noted in 17 (30.9%) patients. Except for elevated serum homocystiene in 11 (22%) controls, other biochemical parameters were within normal range. Conclusions: Implications of hyperhomocystienemia for cardiovascular comorbidities in psoriasis patients and whether supplementing vitamin B 12 and folic acid will prevent comorbidities by normalizing homocystiene metabolism needs evaluation by large well designed studies.