The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation (original) (raw)

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

Roberto Motterlini

Roberta FORESTI, Sandip K. Bains, Tamil Selvi Pitchumony, Lisandra E. de Castro Brás, Filippo Drago, Jean-Luc Dubois-Randé, Claudio Bucolo, Roberto MOTTERLINI, 2013

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NRF2-regulation in brain health and disease: Implication of cerebral inflammation

Carina Mallard, Stephen Weber

Neuropharmacology, 2014

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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Emiliano Panieri

Molecules

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Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance

Jaroslaw Aronowski

Journal of neurochemistry, 2014

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Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

Karen Horsburgh

Journal of Neuroinflammation, 2020

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Opioids Alleviate Oxidative Stress via the Nrf2/HO-1 Pathway in LPS-Stimulated Microglia

Lucie Hejnova, Akash S Mali

International Journal of Molecular Sciences

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Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1

kyoungtae lee

International Immunopharmacology, 2014

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The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1 via Nuclear Factor Erythroid-2-Related Factor 2

Javier Egea

Antioxidants & Redox Signaling, 2013

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Nrf2 Deficiency Exacerbates Cognitive Impairment and Reactive Microgliosis in a Lipopolysaccharide-Induced Neuroinflammatory Mouse Model

Tyler Fernandez

Cellular and Molecular Neurobiology, 2020

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Cerebrovascular and Neurological Disorders: Protective Role of NRF2

Luca Cucullo

International Journal of Molecular Sciences, 2019

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The Nrf2-inducible antioxidant defense in astrocytes can be both up- and down-regulated by activated microglia:Involvement of p38 MAPK

Mats Sandberg

Glia, 2011

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Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

Hiral Patel

Journal of Neuroinflammation

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Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

Manuela López

Antioxidants & Redox Signaling, 2014

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Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways

Sandra Columba-cabezas

Molecular and Cellular Neuroscience, 2010

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Anti-Inflammatory Efficacy of Dexamethasone and Nrf2 Activators in the CNS Using Brain Slices as a Model of Acute Injury

William Hickey

Journal of Neuroimmune Pharmacology, 2012

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Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Takafumi Suzuki

Nature communications, 2016

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Involvement of Nrf2 Activation and NF-kB Pathway Inhibition in the Antioxidant and Anti-Inflammatory Effects of Hesperetin in Activated BV-2 Microglial Cells

Karam Soliman

Brain Sciences

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Nrf2 Expression by Neurons, Astroglia, and Microglia in the Cerebral Cortical Penumbra of Ischemic Rats

Cordian Beyer

Journal of Molecular Neuroscience, 2012

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Bruton's Tyrosine Kinase Is Required for TLR-Dependent Heme Oxygenase-1 Gene Activation via Nrf2 in Macrophages

Vijith Vijayan

The Journal of Immunology, 2011

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Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

Annemieke Rozemuller

Free Radical Biology and Medicine, 2008

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Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation

Kanhaiya Kumawat

Journal of Neuroinflammation, 2012

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Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

Joe McCord, Brooks Hybertson

Molecular Aspects of Medicine, 2011

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Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

Shruti singh

Free Radical Research, 2010

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Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage–induced delayed cerebral vasospasm and secondary brain injury

Chih-lung Lin

PLOS ONE, 2020

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Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ 12,14 -Prostaglandin J 2

Tetsuro Ishii

Molecular and Cellular Biology, 2003

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NRF2 as a Therapeutic Target in Neurodegenerative Diseases

Mikah Brandes

ASN Neuro

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Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

Ángel Juan García Yagüe

Redox Biology, 2018

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Nrf2 activation as a future target of therapy for chronic diseases

Food Science Publisher

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Regulatory Effects of Neuroinflammatory Responses Through Brain-Derived Neurotrophic Factor Signaling in Microglial Cells

Pei-Chun Chang

Molecular Neurobiology, 2018

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Regulation of microglia effector functions by tumor necrosis factor signaling

thi lan Nguyen

Glia, 2011

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Suppression of Nuclear Factor-κB Activation and Inflammation in Microglia by Physically Modified Saline

Supurna Ghosh

Journal of Biological Chemistry, 2012

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