The predictive value of the preoperative diagnostic tests in mature cystic teratomas of the ovary (original) (raw)
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Gynecology Obstetrics & Reproductive Medicine, 2021
OBJECTIVE: Mature cystic teratoma, also known as a dermoid cyst, is the most common germ cell tumor of the ovary. In this retrospective study, it is aimed to evaluate clinicopathological findings of the patients who were operated on due to the preliminary diagnosis of dermoid cyst. STUDY DESIGN: Between May 2013 and May 2018, the findings of a total of 143 patients who were operated on with a preliminary diagnosis of dermoid cyst in our institution were analyzed retrospectively. In addition to demographic characteristics such as age, parity number and tumor size, lateralization, preoperative tumor markers, surgical procedure, presence of other pathological findings, and the rate of malignant transformation were analyzed. RESULTS: The median age of patients was 35.4 years and the ratio of nulliparous, primiparous, and multiparous patients was 46.9%, 25.2%, and 28%, respectively. The median tumor diameter was 6.7 cm, 50.3% of which were right-sided, 46.9% were left-sided and the remai...
Tumor markers in mature cystic teratomas of the ovary
Archives of Gynecology and Obstetrics, 2008
Objective The objective of this study was to evaluate the serum levels of tumor markers in patients with ovarian mature cystic teratomas. Method Retrospective study of 215 patients operated at Zekai Tahir Burak Women Health Education and Research Hospital between January 2001 and October 2006 was performed. Results The median age was 36 years (range 13-80). The mean tumor diameter was 7.7 § 4.6 cm (range 2-25). The mean serum CA 125 level was 26.2 § 29.9 U/mL (range 1.4-225, normal value <35), and the mean serum CA 19-9 level was 83.5 § 179.2 IU/mL (range 0.6-1,000; normal value <37). The elevated rate of CA 19-9, CA 125 was 39.6% (74/187) and 23.3% (50/215), respectively. The mean age of patients and the rate of bilaterality of tumors were similar in both patients with elevated CA19-9 and with normal CA 19-9 level (P > 0.05). The mean tumor size of patients with elevated CA 19-9 was greater than those with normal CA19-9 level (P = 0.01). Conclusion Serum CA 19-9 has the highest positivity rate among other tumor markers in ovarian mature cystic teratomas. Elevated serum CA 19-9 levels are correlated with larger tumor size. But the diagnostic value of elevated CA 19-9 in patients with MCT would be poor if the test was used alone.
The role of tumor markers in predicting mature cystic teratoma of the ovary
2012
The objective of this study was to evaluate size, torsion rate, bilaterality, histopathologic origin, and the serum levels of some tumor markers in patients with mature cystic teratomas of the ovary. Methods. Retrospective study of 110 patients operated at Department of Obstetrics and Gynecology, Bakirkoy Dr. Sadi Konuk Turkey, between January 1998 and December 2003 was performed. The patients were divided into two groups according to cut off levels of each cancer antigens (CA) 19-9 and CA 125. Statistical analysis of the data was performed by Student's t test, Pearson's chisquare test and Mann-Whitney rank sum test. Results. The mean age was 36.01 ± 12,403 years (range 15-78). The mean tumor diameter was 67.83±32.049 mm (range 27-211mm). The mean serum tumor markers of CA 19-9 and 125, carcinoembryogenic antigen and α-fetoprotein levels were 101.2±179.7 IU/mL, 32.0±37.8 U/mL, 1.46±1.20 ng/mL and 2.7±3.0 ng/mL. The bilaterally rate was 6.4% in the normal CA19-9 group and 5.4% in the normal CA125 group. There was no bilaterally in both of the elevated CA19-9 and CA125 groups. The histopathologic component of the teratomas were sebum (70%), hair (62.7%), keratin (20%), cartilage (16.3%) and teeth (3.6%). The torsion rate was 11.5% in the normal CA19-9 group, 15.20% in the normal CA125 group and 15.6% in the elevated CA19-9 group. There was no patient with torsion in the elevated CA125 group. Conclusion. Our study shows that there was no statistical significance between the two analyzed groups in respect to relation between tumor markers and the mean tumor size, bilaterally or torsion rate.
Ovarian dermoid cysts: ultrasonographic fi ndings
Medical ultrasonography, 2009
Dermoid cysts or mature cystic teratoma present various and complex ultrasonographic aspects. That is why the ultrasonographic diagnosis may be diffi cult and lead to confusion. Yet, a thorough analysis of all ultrasound features that characterize dermoid cysts can lead in the vast majority of the cases to an exact diagnosis. The purpose of this paper is to present the ultrasonographic findings of the dermoid cysts.
Preoperative diagnosis of malignant transformation arising from mature cystic teratoma of the ovary
Gynecologic Oncology, 2003
Objective. Mature cystic teratoma of the ovary (MCT) is the most common ovarian cystic disease in young women. Although it is a rare occurrence, some cases develop malignant transformation (MT), which results in serious consequences. However, MT is currently diagnosed only by postoperative pathology in most cases. We have conducted a retrospective study in an attempt to seek the factor to diagnose MT from MCT prior to surgery.
Malignant degeneration of cystic teratoma of the ovary: two cases report
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2020
The malignant degeneration of mature ovarian teratomas is a rare phenomenon. Case reported two cases of squamous cell carcinoma developed on mature teratoma of the ovary in patients aged 54 and 41 who were seen for chronic pelvic pain. Their pelvic ultrasound showed cystic double-component images with sizes of 103 and 95 mm respectively suggestive of dermoid cysts, and the anatomopathological study of the pieces of adnexectomy confirmed the diagnosis. Although no clinical, radiological or biological signs are specific, ovarian dermal cyst degeneration is suspected in the presence of a large dermoid cyst in a postmenopausal or peri-menopausal woman. The careful anatomo-pathological study of the cyst in this case makes it possible to pose the diagnosis of certainty. A rare complication of the dermoid cyst, its prognosis is pejorative and depends mainly on its clinical stage at the time of diagnosis and the quality of its surgical treatment which must be as radical as possible.
Sonographic and histopathological findings in ovarian dermoid cyst
Journal of Patan Academy of Health Sciences, 2017
Introductions: Ovarian dermoid cyst occurs most commonly in reproductive age group. It consists all three layers of germ cells, in variable composition resulting in wide spectrum of USG findings. This study aimed to find the association between sonographic and histopathological findings of dermoid cyst. Methods: This was a retrospective study consisting of 55 cases of complex ovarian cysts with features of dermoid cyst, during two years 2013-2015. The diagnostic accuracies of trans-abdominal sonography findings were compared with post-operative histopathology reports. Results: Among 55 cases of complex ovarian cyst with sonographic features of dermoid, histopathology was benign in 52 (94.5%) and malignant in 3 (5.5%). In 52 benign cysts, 25 (48.0%) were teratoma and 27 (51.9%) were other benign masses. Conclusions: The accuracy of ultrasound was 95% in the diagnosis of ovarian cyst and is the modality of choice for initial workup of ovarian mass.
Journal of clinical and diagnostic research : JCDR, 2017
Mature Cystic Teratoma (MCT) is the most common benign neoplasm of the ovary constituting 10-20% of all the ovarian tumours. Although, much has been published about ovarian teratomas, in English literature, there are very few retrospective cross sectional studies from India to understand the epidemiology of the disease. To evaluate the prevalence, clinicopathological characteristics and complications of MCT of the ovary. This was a retrospective study of 223 cases of MCT of ovary received over a period of 25 years from 1990 to 2014. The data regarding age, size, laterality, gross, morphological features, complications and surgery performed was retrieved from the archives of pathology department. Descriptive statistics was performed using SPSS software version 22 and the results were expressed as percentages. MCT constituted 20.2% of the total ovarian neoplasms and 78.5% of all the germ cell tumours. The mean age of the patients with MCT was 32.5±13.11 years and the mean size of tumo...
Oncology Reports, 2008
The aim of this study was to seek for factors which lead to the early diagnosis of malignant transformation from mature cystic teratoma. Fourteen patients with malignant transformation from mature cystic teratoma of the ovary were analyzed retrospectively for precise clinicopathology and prognosis. The results demonstrated that although all the patients with stage Ia disease were disease-free, only 2 out of 7 patients were stage Ic to IV and disease-free in the follow-up period. Pre-operative imaging correctly diagnosed tumors as malignant in all stage Ic to IV cases, but only in 2 out of 4 stage Ia cases with magnetic resource and none of the 2 cases with computed tomography, respectively. In malignant cases, elevation of the serum SCC and CEA was observed in 90.9 and 88.9%, respectively. On the other hand, in benign cases, a false positive elevation of the serum SCC and CEA was observed in 23.5 and 14.3%, which turned out to be normal in 40 and 52.9% cases in the repeated study, respectively. In conclusion neither imaging analysis nor tumor markers including SCC and CEA accurately diagnose malignant transformation of mature cystic teratoma in its early stage, suggesting that a combination of diagnostic means is important. In the followup cases, repeated measurement of serum markers proved useful in ruling out false positive cases.
An Institution-based study on Cystic Lesions of Ovary in the Konkan belt of Maharashtra State, India
Background: The aims of this study were: 1.) To find out the overall incidence of ovarian cysts in our hospital. 2.) To analyze age incidence of various ovarian cysts studied. 3.)To evaluate various clinical presentation of ovarian cysts. 4.)To find out the incidence of non-neoplastic as well as neoplastic cysts and furthermore incidence of benign and malignant ovarian cysts. 5.)To study the clinico-pathological significance. Methods: 158patients were included in study over a period of three years from August 2014 to July 2017. All the patients with cystic lesions of ovary based on biopsies alone, on resected specimens alone and both consequently were examined and included in the study. All the biopsies specimen and resected specimen were fixed in 10% formalin and processed in automatic tissue processor. Routine Haematoxylin and Eosin staining was done and examined under light microscope. All the data was analyzed with respect to age-wise, sex-wise, site-wise distribution along with incidence of various cystic lesion of ovary studied in all 158 cases. All patients in whom both biopsy and final specimen were resected, histopathological correlation was done in them. Results: Patients in the age group of 41 – 50 years were having maximum number of cystic lesion of ovary in the present study. High adequacy of samples for histopathological examination of cystic lesion of ovary was seen in the present study. Overall, benign lesions were higher in incidence than malignant cystic lesions amongst neoplasticovarian cysts.Menstrual disturbances followed closely by lower abdominal pain were the most commom complaints. Follicular cyst was most commonly diagnosed closely followed by serous cystadenoma.Pain was the main presenting symptom in cases of serous cystic tumors and dermoid cysts whereas mucinous cysts presented mainly with lump in abdomen. Pre-operative guided biopsy helps in prompt management and subsequent better survival, especially in malignancy cases. Conclusion: Most women of reproductive age group develop small cysts each month, and large cysts that cause problems that occur in about 8% of women before menopause. Overall benign lesions were higher in incidence than malignant cystic lesions among neoplastic ovarian cysts.Malignant serous tumor of ovary was the most common malignant ovarian cystic tumor. Pre-operative guided biopsy helps in prompt management and subsequent better survival, especially in malignancy cases. Biopsy findings are subsequently well-correlated with histopathology findings of final resected specimens. This signifies the importance of pre-operative biopsy based diagnosis in patients with problematic ovarian cysts.