The role of tumor markers in predicting mature cystic teratoma of the ovary (original) (raw)
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Tumor markers in mature cystic teratomas of the ovary
Archives of Gynecology and Obstetrics, 2008
Objective The objective of this study was to evaluate the serum levels of tumor markers in patients with ovarian mature cystic teratomas. Method Retrospective study of 215 patients operated at Zekai Tahir Burak Women Health Education and Research Hospital between January 2001 and October 2006 was performed. Results The median age was 36 years (range 13-80). The mean tumor diameter was 7.7 § 4.6 cm (range 2-25). The mean serum CA 125 level was 26.2 § 29.9 U/mL (range 1.4-225, normal value <35), and the mean serum CA 19-9 level was 83.5 § 179.2 IU/mL (range 0.6-1,000; normal value <37). The elevated rate of CA 19-9, CA 125 was 39.6% (74/187) and 23.3% (50/215), respectively. The mean age of patients and the rate of bilaterality of tumors were similar in both patients with elevated CA19-9 and with normal CA 19-9 level (P > 0.05). The mean tumor size of patients with elevated CA 19-9 was greater than those with normal CA19-9 level (P = 0.01). Conclusion Serum CA 19-9 has the highest positivity rate among other tumor markers in ovarian mature cystic teratomas. Elevated serum CA 19-9 levels are correlated with larger tumor size. But the diagnostic value of elevated CA 19-9 in patients with MCT would be poor if the test was used alone.
Morphological Spectrum of Mature Ovarian Teratoma
Background: Teratomas are usually derived from all the three germinal layers. They present as cysts filled with abundant sebaceous material with hair and may contain cartilage, teeth and bone. Solid teratomas pose diagnostic problems especially when the usual ectodermal components are missing on histological examination. The aim of the study is to determine the morphological spectrum of mature ovarian teratoma and to create awareness about the unusual features. Material & Methods: A prospective study consisting of 247 cases of ovarian lesions received at the Department of Pathology, Peshawar Medical College, Peshawar, from January 2012 to October 2013 from its attached teaching hospitals. The patients' data, gross appearance of the ovarian lesions and microscopic findings were recorded. Results: A total of 247 cases were included in this study out of which 234(94.7%) were benign and 13(5.3%) malignant. The commonest benign lesion was hemorrhagic luteal cyst in 50(20.2%) cases, f...
Study of Histomorphological Changes of Teratomas in Tertiary Care Hospital
Journal of Evolution of medical and Dental Sciences, 2013
Teratomas are the germ cell tumors composed of multiple cell types derived from one or more of the three germ layers.Teratomas range from benign well differentiated (mature) cystic lesions to those that are solid and malignant (immature).Additionally, teratomas may be monodermal and highly specialized. Rarely, within some mature teratomas, certain elements like squamous component undergo malignant transformation.Teratomas are known to occur at birth and are derived from pleuripotent germ cells and embryonic cells. Teratomas of embryonic origin are congenital and are seen in the midline of the body - skull, neck, mediastinum, retroperitoneum, and coccyx.Teratomas derived from the germ cells are seen in testis in men and ovaries in women. AIMS: This prospective and retrospective study was conducted to determine the frequency of the teratomas occurring in various sites along with their histomorphological presentations. MATERIALS AND METHODS : The study was conducted at Rajarajeswari Me...
Marmara Medical Journal
Objectives: Mature cystic teratomas (MCT) originate from three germ layers: ectoderm, mesoderm and endoderm. The predictive significance of tumor markers in mature cystic teratomas is still unclear. In this study, we aimed to evaluate the predictive value of tumor markers in ovarian MCTs and histopathological contents of tumor. Materials and Methods: The data of 106 patients who were operated for ovarian MCT between 2015 and 2020 were retrospectively analysed. In addition, slides in the pathology archive were reexamined under a microscope to evaluate their histopathological contents. Results: The average age of the patients was 35.7; 26.7 in the cystectomy group and 42.1 in the oophorectomy group (p = 0.000). The ratio of tumor markers exceeding the cut off value for carbohydrate antigen (CA 19-9), lactate dehydrogenase (LDH), cancer antigen (CA 125), carcinoma antigen (CA 15-3), carcinoembryonic antigen (CEA) were 45.2%; 47.7%; 8.15%; 12.3%; 6.9%, respectively. Histopathological examination of MCTs revealed 99.1% ectoderm, 45.3% mesodermal, 39.6% endodermal origin. Conclusion: Mature cystic teratoma is a benign tumor of the reproductive age that contains three germ layers in various proportions. LDH and CA 19-9 can be a helpful tool in predicting mature cystic teratomas.
Journal of the Chinese Medical Association, 2017
Background: Serum tumor markers are widely used for the preoperative evaluation of an adnexal mass. Elevations of cancer antigen (CA) 125 and CA 19-9 have been reported in patients with mature cystic teratoma (MCT). The aim of the study is to investigate the relation of serum tumor markers with tumor characteristics in young women with MCT. Methods: We conducted a retrospective review of 157 patients under the age of 35 who underwent laparoscopic surgery for ovarian MCT. Patients were divided into two age groups: Group I (n ¼ 80): adolescents/young adults (aged 13e25 years) and Group II (n ¼ 77): women aged 26e35 years. Data were analyzed for serum tumor markers, tumor size, and bilaterality. Results: The rates of elevated CA 125 and CA 19-9 were 10.7% and 31.5%, respectively, for Group I, and 13.9% and 26.5%, respectively, for Group II. The bilaterality rate was higher in Group II compared to Group I (19.5% vs. 8.8%, respectively, p ¼ 0.04). Serum CA 125 and CA 19-9 elevations were not related to tumor size in Group I. In Group II, elevated levels of CA 125 were also unrelated to tumor size. However, significant elevation in CA 19-9 levels was observed when tumor size was larger than 4 cm in this age group (p ¼ 0.004). Elevated CA 125 and CA 19-9 levels were not significantly associated with the presence of bilateral MCT in either group. Conclusion: The results of our study indicate that elevations of CA 19-9 are associated with larger tumor size in women aged 26e35 years, but not in adolescents/young adults. However, elevated serum CA 125 levels are not related to tumor size in either age group.
Ovarian Teratoma in Routine Biopsy Material During a Five-Year Period
Acta clinica Croatica, 2016
Teratomas are tumors derived from germ cells, most frequently arising in the gonads. The aim of this study was to determine the number of ovarian teratomas diagnosed in the routine biopsy material at Ljudevit Jurak Clinical Department of Pathology, Sestre milosrdnice University Hospital Center during a 5-year period, as well as their clinical, gross and microscopic characteristics. Teratomas accounted for 48.6% (n=166) of primary ovarian tumors. The patient mean age was 34.74±12.37 years. Difference in the incidence of teratoma between the left and right ovary was not significant; bilateral teratoma was found in 13 patients. Teratomas were detected by ultrasonography in 115 (69.27%) cases and the rest were found during surgery performed for other indications. Most teratomas (n=161; 96.9%) were mature and cystic (dermoid cysts). Mature and solid teratomas were diagnosed in 5 (3.01%), ovarian struma in 2 (1.8%) cases and strumal carcinoid in 1 (1.2%) case. Mature cystic teratomas cont...
Oncology Reports, 2008
The aim of this study was to seek for factors which lead to the early diagnosis of malignant transformation from mature cystic teratoma. Fourteen patients with malignant transformation from mature cystic teratoma of the ovary were analyzed retrospectively for precise clinicopathology and prognosis. The results demonstrated that although all the patients with stage Ia disease were disease-free, only 2 out of 7 patients were stage Ic to IV and disease-free in the follow-up period. Pre-operative imaging correctly diagnosed tumors as malignant in all stage Ic to IV cases, but only in 2 out of 4 stage Ia cases with magnetic resource and none of the 2 cases with computed tomography, respectively. In malignant cases, elevation of the serum SCC and CEA was observed in 90.9 and 88.9%, respectively. On the other hand, in benign cases, a false positive elevation of the serum SCC and CEA was observed in 23.5 and 14.3%, which turned out to be normal in 40 and 52.9% cases in the repeated study, respectively. In conclusion neither imaging analysis nor tumor markers including SCC and CEA accurately diagnose malignant transformation of mature cystic teratoma in its early stage, suggesting that a combination of diagnostic means is important. In the followup cases, repeated measurement of serum markers proved useful in ruling out false positive cases.
Mature cystic teratomas in our series with review of the literature and retrospective analysis
Archives of Gynecology and Obstetrics, 2011
Purpose Mature cystic teratomas are the most common benign ovarian neoplasms. Our aim is to analyse these cases by pathologic and clinical findings in our centre with the view of updated knowledge. Materials and methods In our study, 50 case reports diagnosed as mature cystic teratoma (or dermoid cyst) in Mustafa Kemal University Pathology Laboratory between 2005 and 2010 have been reviewed. Results Of 50 cases, the findings on mature cystic teratomas were as follows: the number of tumours located at the right ovary was 22, the left ovary, 23, with 5 cases bilaterally. Age range was 14-58 with mean rate 35.4. In two cases, tumour markers were high, one case presented with torsion; one case was obtained incidentally during delivery. Conclusion Mature cystic teratomas are benign neoplasms with low malign transformation rate. Our series are low in number but our findings show the dynamic nature of these tumours.
Teratomas: A Multimodality Review
Current Problems in Diagnostic Radiology, 2012
Germ cell tumors (GCTs) may occur in both children and adults and include a broad array of histologic subtypes, such as teratoma, seminoma (known as dysgerminoma in the ovary and germinoma in the pineal gland), choriocarcinoma, yolk sac tumor, embryonal cell carcinoma, and mixed GCT. In adults, GCTs occur most commonly in the gonads. In children, sacrococcygeal tumors predominate. Teratomas are a common form of GCT. They are defined histologically as containing tissues derived from all 3 germ cell layers: ectoderm, mesoderm (most teratomas contain fat, an imaging hallmark, which is a mesodermal derivative), and endoderm. Teratomas are also classified as mature or immature, depending on the degree of differentiation of its components, and in adults, immature tumors are more likely to exhibit malignant behavior.