original ) (raw )A Mouse Model for the Carney Complex Tumor Syndrome Develops Neoplasia in Cyclic AMP-Responsive Tissues
Lawrence Kirschner
Cancer Research, 2005
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Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease!
Sotirios Stergiopoulos
FEBS Letters, 2003
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The Transcriptome that Mediates Increased Cyclic Adenosine Monophosphate Signaling in Prkar1a Defects and Other Settings
Constantine Stratakis
Endocrine Practice, 2011
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Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex
Lawrence Kirschner
Journal of Internal Medicine, 2009
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A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions
Constantine Stratakis
Journal of Medical Genetics, 2004
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cAMP/PKA signaling defects in tumors: Genetics and tissue-specific pluripotential cell-derived lesions in human and mouse
Constantine Stratakis
Molecular and Cellular Endocrinology, 2013
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PRKAR1A and the evolution of pituitary tumors
Lawrence Kirschner
Molecular and Cellular Endocrinology, 2010
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Protein kinase A and its role in human neoplasia: the Carney complex paradigm
Fabiano Sandrini
Endocrine Related Cancer, 2004
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PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex
Fabiano Sandrini
Journal of Medical Genetics, 2002
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Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis
Constantine Stratakis
Human Molecular Genetics, 2007
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Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus
Stein Doskeland
British journal of cancer, 1992
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Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors
Constantine Stratakis
Cancer Research, 2004
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PRKAR1A and Thyroid Tumors
Constantine Stratakis
Cancers, 2021
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A Large Family with Carney Complex Caused by the S147G PRKAR1A Mutation Shows a Unique Spectrum of Disease Including Adrenocortical Cancer
Constantine Stratakis
The Journal of Clinical Endocrinology & Metabolism, 2012
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PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors
Constantine Stratakis
Frontiers in cell and developmental biology, 2015
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Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis
Paraskevi Salpea
Endocrine-Related Cancer, 2016
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p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a
Martijn Nawijn
Nature, 2007
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Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update
Constantine Stratakis
Human Mutation, 2010
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PRKAR1A Inactivation Leads to Increased Proliferation and Decreased Apoptosis in Human B Lymphocytes
Eiman Aleem
Cancer Research, 2006
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Clinical and molecular genetics of Carney complex
Constantine Stratakis
Best Practice & Research Clinical Endocrinology & Metabolism, 2010
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E pluribus unum? The main protein kinase A catalytic subunit (PRKACA), a likely oncogene, and cortisol-producing tumors
Constantine Stratakis
The Journal of clinical endocrinology and metabolism, 2014
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Differential effects of protein kinase a sub-units on chinese-hamster-ovary cell cycle and proliferation
Stefano Pepe
International Journal of Cancer, 1994
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Unexpected Roles for pRb in Mouse Skin Carcinogenesis
Mirentxu Santos , Jesus M Paramio
Cancer Research, 2005
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An Immortalized Human Cell Line Bearing a PRKAR1A-Inactivating Mutation: Effects of Overexpression of the Wild-Type Allele and Other Protein Kinase A Subunits
Constantine Stratakis
The Journal of Clinical Endocrinology & Metabolism, 2008
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Molecular Analysis of the Cyclic AMP-Dependent Protein Kinase A (PKA) Regulatory Subunit 1A (PRKAR1A) Gene in Patients with Carney Complex and Primary Pigmented Nodular Adrenocortical Disease (PPNAD) Reveals Novel Mutations and Clues For Pathophysiology: Augmented PKA Signaling is Associated with...
Constantine Stratakis
The American Journal of Human Genetics, 2002
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Molecular and Functional Analysis of PRKAR1A and its Locus (17q22–24) in Sporadic Adrenocortical Tumors 17q Losses, Somatic Mutations, and Protein Kinase A Expression and Activity
Thalia Bei , Sotirios Stergiopoulos
Cancer Research, 2003
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Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts
Alfredo Budillon
1994
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Biochemical Characterization of Extracellular cAMP-Dependent Protein Kinase as a Tumor Marker
saleh mohamed
Biochemical and Biophysical Research Communications, 2000
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Expression of Wilms’ Tumor Suppressor Gene ( WT1 ) in Term Human Trophoblast: Regulation by Cyclic Adenosine 3′,5′-Monophosphate 1
Chung L Li
The Journal of Clinical Endocrinology & Metabolism, 1998
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Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell Cycle Exit, Differentiation, and Determination of Cell Fate
Farruk Kabir , Payal Agarwal
Tumor Suppressor Genes, 2012
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Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2
Constantine Stratakis
Human Molecular Genetics, 2003
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