Evaluation of Traditional Herb Extract Salvia officinalis in Treatment of Alzheimers Disease (original) (raw)
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European review for medical and pharmacological sciences, 2012
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Increased oxidative stress has been shown to be a prominent and early feature in AD. Medicinal plants with antioxidant activities have been used traditionally in the treatment of several human diseases. The present study aims to investigate the effect of Salvia triloba and Piper nigrum plant extracts on the oxidative stress status in Alzheimer's disease induced in rats. 70 male rats were enrolled in this study and were classified into 7 groups (ten each). Group 1: control group, group 2: AD-induced rats by aluminum chloride, and served as positive control; group 3: AD group treated with Rivastigmine in a dose of 0.3 mg/kg b. wt. daily for three months; group 4 & 5: AD group treated with total extract of Salvia triloba in a dose of 750 or 375 mg/kg b. wt. respectively, daily for three months; group 6 & 7: AD group treated with total extract Piper nigrum in a dose of 187.5 or 93.75 mg/kg b. wt. respectively,...
Der Pharmacia Sinica
Salvia officinalis is a Ayurvedic traditional medicinal plant in India and is considered useful in various ailments. Preliminary neuropsychopharmacological evaluation revealed cognition enhancing ability of the flower extract of the plant. Therefore, the present study aims at evaluating the potential effectiveness of the methanol extract of the flowers of this plant in dementia related to Alzheimer's disease (AD). Dementia was induced experimentally in animals by ingesting excess Copper and Aluminium in drinking water and confirmed by Radial 8 arm maze test. Differentl biochemical parameters including superoxide dismutase (SOD), glutathione-oxidized (GSSG), reduced glutathione (GSH), nitrite estimation, myeloperoxidase (MPO) activity and acetylcholinesterase (AChE) activity were also estimated. Lipid profile was also evaluated along with the histopathological observations. Results demonstrated a neuroprotective profile of the methanol extract of the flowers of Salvia officinalis...
Recent updates on role of herbal medicine for Alzheimer's disease (Dementia)
International Journal of Current Research in Biosciences and Plant Biology, 2021
This review paper highlights the use of medicinal plants in the management of Alzheimer's disease and memory deficit. Alzheimer’s disease is the most common form of dementia, a serious brain disorder that impacts daily living through memory loss and cognitive changes. Alzheimer's disease is also agerelated neurodegenerative disorders caused by progressive loss of structure or function of neurons, resulting in neuronal cell death. Alzheimer's patients have an acetylcholine deficiency. Stressful conditions, free radicle scavanging and oxidation are often associated with loss of memory and cognitive functions, which may lead to threats of schizophrenia and Alzheimer's disease. However, the use of allopathic drugs has resulted in the adverse side effects on the human body and thus limits the use of such drugs. Herbal cognitive enhancer drugs have shown their potent effect in Alzheimer’s disease due to their antioxidant and neuropharmacological actions. The use of natural cognitive enhancers evidenced to improve mental functions such as cognition, memory, intelligence, motivation, attention and concentration. Traditional Ayurvedic herbal system of medicine is fundamentally preventive, protective, nutritive, curative and less expensive. Therefore, the use of herbal medicine for the treatment of Alzheimer's disease is a novel approach without any side effects.
Recent updates on the role of herbal medicine for Alzheimer's disease (Dementia)
Alzheimer's disease (Dementia), 2021
This review paper highlights the use of medicinal plants in the management of Alzheimer's disease and memory deficit. Alzheimer's disease is the most common form of dementia, a serious brain disorder that impacts daily living through memory loss and cognitive changes. Alzheimer's disease is also agerelated neurodegenerative disorders caused by progressive loss of structure or function of neurons, resulting in neuronal cell death. Alzheimer's patients have an acetylcholine deficiency. Stressful conditions, free radicle scavanging and oxidation are often associated with loss of memory and cognitive functions, which may lead to threats of schizophrenia and Alzheimer's disease. However, the use of allopathic drugs has resulted in the adverse side effects on the human body and thus limits the use of such drugs. Herbal cognitive enhancer drugs have shown their potent effect in Alzheimer's disease due to their antioxidant and neuropharmacological actions. The use of natural cognitive enhancers evidenced to improve mental functions such as cognition, memory, intelligence, motivation, attention and concentration. Traditional Ayurvedic herbal system of medicine is fundamentally preventive, protective, nutritive, curative and less expensive. Therefore, the use of herbal medicine for the treatment of Alzheimer's disease is a novel approach without any side effects.
BMC Complementary and Alternative Medicine, 2013
Egyptians recognized the healing power of herbs and used them in their medicinal formulations. Nowadays, "Attarin" drug shops and the public use mainly the Unani medicinal system for treatment of their health problems including improvement of memory and old age related diseases. Numerous medicinal plants have been described in old literature of Arabic traditional medicine for treatment of Alzheimer's disease (AD) (or to strengthen memory).
Herbal Approaches for Alzheimer Disease: A Review
Journal of Pharmaceutical Research International
"Plague of the Twenty-First Century," or "Alzheimer disease" is anneuro-degenerative disease that influenced the world's elderly population. The prevalence of Alzheimer's disease is expected to increase to one hundred thirty-five million by 2050, with no treatment(s) currently available to cure or monitor the disease's progression. The current treatment(s) have lesscapability to manage symptoms or delay disease development, and they can cause serious side effects. The cost of overall treatment is high for both the patients and their caregivers or family members. As an example, there is an serious requirement to find safer alternative treatments for better management of Alzheimer's disease. The various Indian herbal medicines such as Centella asiatica,Celastruspaniculatus Curcuma longa, Clitoriaternatea,Bacopa monnieri, Withania somnifera, has been reviewed in this article. Eclipta alba, Desmodiumgangeticum, Evolvulusalsinoides, Moringa oleifera, and Convolvulus pluricaulis are among the plants that have shown promising effect in the treatment related to cognitive disability.
Role of Medicinal Plants for the Treatment of Alzheimer’s Disease
Journal of pharmaceutical research international, 2021
In today's era, most of the diseases are treated by allopathic drugs. The reliance on allopathic drugs for the treatment of most diseases is gradually increasing day by day due to their rapid effects and the immediate relief to patients. However, these drugs induce some serious side effects in patients, and in some cases, the patient may die. Thus, the interest of researchers is growing day by day towards medicinal plants for the treatment of diseases. It has also been viewed that some herbal plants have great therapeutic and pharmacological effects in the treatment of Alzheimer's disease. The initial studies, which have been carried out by different researchers, demonstrated very valuable results and enlighten a ray of hope for the treatment of Alzheimer's disease which is associated with CNS disfunction. In this article, the author focused on those plants which are especially used in the treatment of Alzheimer's disease.
Pharmacological and Herbal remedies in the Management of Neurodegenerative Disorder (Alzheimer’s)
International Journal of Pharmacognosy and Life Sciences, 2021
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder and has become a great health problem particularly among the elderly people, generally occurs after the age of 55 years and increase in incidence with advancing age, affecting nearly 25 million people worldwide. Alzheimer's disease (AD) was first identified by the German psychiatrist, Alois Alzheimer, in 1907. People with this disease may exhibit symptoms of short-term memory loss, diminished motor skills, inefficient coordination and impaired intellectual capabilities. The cause of AD is not exactly known, but is thought to include both genetic and environmental factors (multifactorial). There is no known cure for Alzheimer's disease, since it is not possible to reverse the death of brain cells but the symptoms can be managed by some pharmacological agents and herbal remedies. The herbal remedies are becoming more popular in the recent years and providing very promising benefits to the patients suffering from AD. Several clinical trials using herbal mixtures are also going on and will hopefully show positive results for treating AD in the future. This paper reviews the Pathophysiology of AD along with the synthetic drugs and herbal medicines which are used for the Management of AD.
Journal of Young Pharmacists, 2023
Alzheimer's disease (AD), the most common type of dementia, is a progressive neurodegenerative disease severely affecting memory and cognitive function. It causes linguistic and visuo-spatial deficiencies, and behavioral problems like indifference, aggressiveness and depression as disease progresses advanced stages. No cure is available for Alzheimer's, though symptomatic treatment improves memory and other symptoms. Natural products ease the symptoms of many kinds of diseases and offer a treatment option for many diseases at least successfully slowing the progress. Medicinal plants and plant products have been historically employed to improve brain function and treat memory disorders like amnesia, dementia. Though, various studies have described the utility of plants for treatment of Alzheimer's, but with limited scientific evidence. Though, it has been reported that early start of utilization memory enhancing agents and brain tonics can be beneficial in AD. The present review is to summaries the herbal medicines which have reported to have some kind of CNS activity and may be utilized for slowing progression, symptomatic treatment and research in the treatment of Alzheimer's disease (AD) and its related symptoms.
A Review on Herbal Remedies for Alzheimer’s Disease
Journal of Natural Remedies
Among the neurodegenerative disorders, Alzheimer’s disease is the most common type where the individual suffers from dementia. It usually affects citizens aged 65 and above. Its high prevalence and debilitating effects call for the need of effective therapeutic interventions to deal with this grave disease. The inefficiency of currently available therapeutic options pushes our attention towards finding effective alternative therapeutic options to either successfully prevent or treat AD. Herbal remedies are a potential gold mine that offer hope against this crippling disease. The aim of this review is to throw a light on the potential of a few potential and promising herbal which can provide an alternative therapeutic intervention for the prevention and management of AD amongst a plethora of herbal drugs.