Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth. in alloxan induced diabetic albino mice (original) (raw)
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European Journal of Medicinal Plants
Background: Diabetes Mellitus is a debilitating metabolic disease characterized by hyperglycemia due to insufficient insulin or inability of insulin receptors to respond positively to circulating insulin. Prevalence of the disease is on the global increase annually with tendency to rise from 380 to over 592 million by 2035 in developing countries. Toxicity of some Orthodox drugs in use has led to searches for alternative sources for treatment and management of the disease. Aim: This work was aimed at investigating the effect of methanolic extract of Albizia lebbeck leaf on Alloxan monohydrate induced diabetic albino rats. Materials and Methods: Qualitative Phytochemical analysis of the plant extract was carried out in Biochemistry Division of National Veterinary Research Institute Vom, Plateau State, Nigeria. Forty female Wistar albino rats were used for the study, divided into five groups (A-E) in two replicates. Group A- negative control (non-induced, not treated) and group B- pos...
Nigerian Journal of Basic and Applied Sciences, 2010
The research investigated the hypoglycaemic and hypolipidaemic effects of aqueous and organic solvents extracts of Albizzia chevalieri root in alloxan-induced diabetic rats. The aqueous extract was administered at 100, 200 and 300mg/kg body weight while the organic solvent fractions of the aqueous extract were administered at 100mg/kg body weight. The 300mg/kg body weight of the aqueous crude extract caused a 24% reduction of serum glucose level of the diabetic rats. The chloroform and hexane fractions caused 25 and 24% reduction of serum glucose level of the diabetic rats. The results were comparable to 28% reduction obtained for treatment with 3.57mg/kg body weight of chlorpropamide. The petroleum ether fraction decreased serum total cholesterol, triaclglyceride, and very low density lipoprotein cholesterol levels significantly (P<0.05). chloroform fraction and last water extract fractions increased the high density lipoprotein cholesterol level of the diabetic rats. The results demonstrate that the aqueous root extracts of Albizzia chevalieri posses significant (P<0.05) hypoglycaemic and hypolipidemic effects in alloxan induced diabetic rats. The extract may be a potential source of lead compound(s) with anti-diabetic properties.
International Journal of Pharmacy and Pharmaceutical Sciences, 2012
Diabetes is a global health problem. The number of people with diabetes is increasing due to population growth, aging, urbanization, and increasing prevalence of obesity and physical inactivity. Due to the current global interest on natural or traditional remedies, the present work on Albizzia myriophylla or tebu gajah may provide another alternative to the treatment of diabetes. Initially, oral glucose tolerance test was carried out in normal rats treated with 5 mg/kg, 25 mg/kg and 50 mg/kg of aqueous bark extract of Albizia myriophylla, respectively. This was then followed by administration of the same extract, at doses of 5 mg/kg and 25 mg/kg, respectively, to normal and streptozotocinnicotinamide induced diabetic rats for 4 weeks. Subsequently, fasting blood glucose levels, changes in body weight, serum insulin, C-peptide, the liver enzymes including aspartate transaminase, alanine transaminase, the renal function test including urea and creatinine, together with cholesterol and...
Scientific Journal of Biological Sciences, 2013
The study investigated the anti-diabetic and haematological effects of n-butanol fraction of Alchornea cordifolia in streptozotocin-induced diabetic wistar rats. In this work, thirty six adult strain of albino wistar rats were used, which included six normal, diabetic untreated and twenty four diabetic treated rats. Diabetes mellitus was induced by single intraperitoneally injection of 60 mg/kg body weight dose of streptozotocin dissolved in 0.1 ml fresh cold citrate buffer pH 4.5 into 16 h-fasted rats. Diabetic rats were randomly divided as follows: Group I served as normal control, Group II served as diabetic untreated rats, while Group III to Group VI received 200, 400 and 800mg/kg b w of the extract and glibenclamide 10mg/kg b w respectively by orally by gavages for a period of 28 days. The animals were weighed weekly to determine the change in body weight. Fasting blood glucose was measured after every seven days. After the last day of treatment, blood samples were collected from the animals from each group on the 29 th day by cardiac puncture in 16 hours fasted animals for the determination of haematological parameters. The results obtained in this present study showed that the blood glucose level was 46 significantly (p<0.05) decreased in the animals administered with 200mg/kg b w of the extract, with a higher decrease (p < 0.01) observed in the group that received 400 and 800mg/kg b w extract respectively when compared to the diabetic control group. However, there was a significantly increased (p<0.05) body weight of diabetic animals that received all doses of the extract after 14 th , 21 st and 28 th day when compared to diabetic control group. There was a statistically significant increase (p<0.05) in packed cell volume, red cell count, haemoglobin concentration and total protein in the extract treated diabetic animals. The total white blood cell count and lymphocyte revealed a significantly (p<0.05) increased the levels after treatment with the extract after 28 th days. In conclusion, the plant extract showed a significant hypoglycemic as well as erythropoetic effects in the diabetic animals, justifying its use traditionally in the management of diabetes mellitus.
Antihyperglycemic, Hypoglycemic and Cytotoxic Activity of Albizia lebbek and Trigonella corniculata
Research Journal of Pharmacy and Technology, 2014
Antihyperglycemic, hypoglycemic and cytotoxic activities of methanolic extract of Albizia lebbeck and Trigonella corniculata were studied. Hypoglycemic action of plants was investigated using normoglycemic rabbits (acute study only), whereas antihyperglycemic activity was studied using alloxan induced diabetic rabbits (acute and chronic study). Results revealed both plant extracts and their mixture having significant anti diabetic potential at dose of 200mg/kg comparable to standard drug Glibenclamide (0.5 mg/kg). Brine shrimp assay was used for the determination of cytotoxicity and results showed plants to have low toxic potential (LD50>1000 μg). The study conducted proves both plants and their mixture to have high potential for the treatment of diabetes.
Journal of Diseases and Medicinal Plants, 2019
Many plants have been used for the treatment of diabetes mellitus in Jordanian system of medicine and in other ancient systems of the world. The present study is aimed to evaluate the potential mechanism of antidiabetic action of aqueous extract of Alkanna strigosa aerial part and its hypolipidemic effects in normal and alloxan-induced diabetic rats. This study was conducted on fifty experimental animals. Adult albino rats (Sprague-Dawely strain) weighing about 220 g each were used throughout the study. Fifty rats were randomly assigned to five experimental groups of 10 rats each: Group 1-received normal saline (0.5 ml/kg), and serves as control. Group II-gavaged daily for thirty days with 1ml of the extract at doses of 400 mg/kg body wt and served as control. Group III-Untreated diabetic rats that received two doses of alloxan 150 mg/kg. Group IV-Treated diabetic rats for thirty consecutive days with 1 ml of the extract at a dose of 400 mg/kg body wt. Group V: Treated diabetic rats for thirty consecutive days with 14.2 mg/kg of metformin. Several hematological and biochemical parameters were assessed. It was found that the administration of aqueous extract of Alkanna strigosa produced significant reduction in blood glucose level in diabetic rats after thirty days of treatment. However, there was a significant (p < 0.05). Increase of insulin secretion. Also, the RBC and WBC count, PCV and neutrophil percentage decreased significantly (p < 0.05). This study indicated that the aqueous extract of Alkanna strigosa increased the RBC and WBC counts, PCV, ESR, and neutrophil percentage in diabetic rats. However, the WBC count of the extract-treated diabetic group was still lower than those of control values. Administration of the extract resulted in a significant reduction in the mean values of serum cholesterol, triglyceride, LDL-C, ESR, urea, uric acid, creatinine accompanied by an increase in the mean values of total protein, albumin, insulin, HDL-C, neutrophile count and PCV in diabetic rats. No significant changes in these parameters were found in the control group. Effects produced by this extract were closely similar to a standard antidiabetic drug, metformin. (p < 0.05) hypoglycemic effects in alloxan-induced diabetic rats, protection against body weight loss of diabetic animals and might alleviate diabetes-induced disturbances of some biochemical and hematological parameters. These results suggest that the oral administration of aqueous extract of the aerial part of Alkanna strigosa possesses antidiabetic and hypolipidemic effects in alloxan-induced diabetic rats.
Cameroon Journal of …, 2009
Aqueous leaf extract of Albizzia chevalieri and its fractions have been reported to possess significant hypoglycaemic effect. In the current work the effects of aqueous leaf extract of Albizzia chevalieri and the column chromatographic fractions, of the extract with hypoglycaemic effect, on serum lipid profile of alloxan induced diabetic rats were studied. The aqueous extract was fractionated with organic solvents and the fractions further fractionated using column chromatography. The results indicated that the aqueous leaf extract caused significant (P<0.05) decrease in triacylglycerol (14 %), LDLcholesterol (16 %), VLDL-cholesterol (19 %) and atherogenic index (45 %). The hexane fraction of the aqueous extract which was reported to possess significant hypoglycaemic effect caused significant reduction in serum total cholesterol (57 %), triacylglycerol (29 %), LDL-cholesterol (75 %), VLDL-cholesterol (67 %) and atherogenic index (72 %) in the rats. The second elution fraction of the hexane fraction from the column, which is dark brown in colour and was earlier reported to contain the hypoglycaemic agent also reduced the serum levels of total cholesterol, triacylglycerol, LDL-cholesterol, VLDL-cholesterol and atherogenic index by 66, 54, 78, 80 and 76 % respectively. These results may be indicative of the fact that the aqueous leaf extract of Albizzia chevalieri, in addition to it hypoglycaemic activity, also possesses significant hypolipidaemic effect. It may be worthwhile therefore to study the nature and mechanism of action(s) of the agent(s) responsible for the observed effects.
Preliminary phytochemical analysis of different plant parts of Albizia odoratissima (L.F.) benth
Journal of Medicinal Plants Studies, 2020
Various traditional system of medicine enlightens the importance of plant Albiziaodoratisssima (L. f.) Benth (Family: Fabaceae) have a great value. Traditionally this plant used in treatment of leprosy, ulcer, skin diseases cough, bronchitis. The present study was aimed to preliminary phytochemical studies of this plant. The objective of these study was subjected to preliminary phytochemical screening was to screen aqueous, methanol and chloroform extract of dried powder of leaves, stem and seed of these plant. This study is useful to detect the different phytochemicals like alkaloid, carbohydrates, reducing sugar, phytosterols, saponins, phenolic compound, tannins, flavonoids, terpenoids, cardiac glycosides, steroids etc. The phytochemical evolution revealed the presence of carbohydrate, phytosterol, saponins, terpenoid, in plant parts like leaf, stem bark and seeds.
Effect of Aloe vera and metformin on diabetic albino rats
Pure and Applied Biology, 2020
Diabetes mellitus refers to a predominant concern characterized by excessive glycemia, glycosuria, as well as hyperlipemia; resulting from deficiency of insulin. Plants have always been paid attention as suitable substitutes for chemical drugs due to easy accessibility, fewer side effects, low-toxicity, and cost-effectiveness exhibiting reportedly helpful effects. In the present study, Alloxan monohydrate 150mg/kg body weight was administrated intraperitoneally to induce diabetes in rats, the effect of Aloe vera leaf gel and Metformin on blood glucose and body weight were compared. Aloe vera gel in a concentration of 1000mg/kg body weight and metformin at concentration 150mg/kg body weight was orally administered in induced diabetic in rats. There was a significant difference of (p<0.05) recorded in blood glucose level and body weight in the control and treated groups. The glucose level in blood was decreased in all treated groups (aloe vera treated group and metformin-treated group) except control diabetic group: whereas after induction of diabetes bodyweight of all diabetic groups were decreased. After treatment with aloe vera and metformin, there was a significant increase in body weight of treated groups as compared with the diabetic control group.