Anti-IgE treatment of eosinophil-associated gastrointestinal disorders (original) (raw)
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Does IgE Bind to and Activate Eosinophils from Patients with Allergy?
The Journal of Immunology
Human eosinophils have been reported to express both the mRNA and protein for the high affinity IgE receptor (FcεRI); it is speculated that this receptor plays a role in eosinophil mediator release in allergic diseases. However, questions still remain. How much of the FcεRI protein is actually expressed on the cell surface of the eosinophil? If they are present, are these IgE receptors associated with effector functions of eosinophils? To address these issues, we studied blood eosinophils from patients with ragweed hay fever. A high level of low affinity IgG receptor (FcγRII, CD32), but no expression of FcεRI, was detectable on the eosinophil surface by standard FACS analysis. However, after in vitro sensitization with biotinylated chimeric IgE (cIgE), cell-bound cIgE was detected by PE-conjugated streptavidin. This cIgE binding was partially inhibited by anti-FcεRI mAb, suggesting that eosinophils do express minimal amounts of FcεRI detectable only by a sensitive method. Indeed, FA...
A Study on Total Serum IgE Levels and Absolute Eosinophil Count in Allergic Rhinitis Patients
Journal of Evolution of Medical and Dental Sciences, 2020
BACKGROUND Allergic rhinitis is an IgE mediated hypersensitivity disease of the mucous membrane of nasal airway characterized by sneezing, itching, watery nasal discharge and sensation of nasal obstruction. METHODS The aim of the study was to evaluate the total serum IgE levels and absolute eosinophil counts in patients with allergic rhinitis, and rhinitis with asthma. In this study, 160 patients of allergic rhinitis attending ENT OPD were clinically examined and investigated with Total Serum IgE levels and absolute eosinophil counts. Statistical analysis was done using SPSS software. RESULTS 160 study subjects with signs and symptoms of allergic rhinitis were investigated with total serum IgE levels and absolute eosinophil count. 46.25% were males and 53.75% were females. The patients included in the study were aged 10-60 years. Seasonal symptoms were observed in 44% of patients while perennial symptoms were experienced by 56% of the patients. As per ARIA classification, 66.3% had mild, 6.9% had moderate and 26.9% had severe allergic rhinitis. Bronchial asthma was found to be the most common comorbidity present in 13% of subjects, associated sinonasal polyps which was present in 13.8%. 71.9% had raised Total Serum IgE levels and eosinophilia was present in 59.4%. A significant relationship exists between total IgE levels and eosinophilia in patients with allergic rhinitis. CONCLUSIONS Allergic rhinitis is an IgE mediated inflammatory disease and raised total serum IgE levels and raised absolute eosinophil count in study subjects with clinical signs and symptoms of rhinitis are likely to correlate with allergic aetiology.
Total IgE and Absolute Eosinophils Count as a Predictor of Allergic Diseases in Children
Egyptian Journal of …
Objective: To study the role of both serum total IgE levels and the absolute eosinophils count, total IgE alone, absolute eosinophils count alone as a marker of allergy in children, and to see their association with the host factors (age and sex) Methods: A retrospective study was conducted at King Abdul Aziz University Hospital-Jeddah (KAUH), during the year 2008. Three hundred children below the age of fifteen years meeting the inclusion criteria were enrolled for the study. Serum total IgE levels and absolute eosinophils count were done in all patients. Data was collected and tabulated. Chi-square was applied to test the association of the variables using SPSS and p-value of <0.05 was taken as statistically significant. Results: Out of 300 patients, 27(9%) had raised both serum total IgE and absolute eosinophils count, 146(48.67%) had raised serum total IgE alone, 40(13.3%) had raised absolute eosinophils count alone. Both IgE plus absolute eosinophilic count, total IgE alone and absolute eosinophilic count alone are not significantly related to the child sex with (P-values 0.759, 0.742, 0.699) respectively, however all are related significantly to the child age (P-values <0.004, <0.001, <0.012) respectively. All are not related significantly to systemic allergies except the significant relation between the absolute eosinophils count with atopic dermatitis (Pvalue <0.031) Conclusion: Serum total IgE level and absolute eosinophils count, total IgE alone and absolute eosinophils count alone are not a good predictor of allergy in children except that the absolute eosinophils count can be considered as a strong predictor of atopic dermatitis in children. It's clear now, that as the child age increase the positivity of all the tests increase also. CORE Metadata, citation and similar papers at core.ac.uk
İstanbul Kuzey Klinikleri, 2022
A topy is the genetic predisposition for the production of antibody immunoglobulin E (IgE) as a response to low-dose common environmental factors such as pollen, house dust mites, and food allergens. An atopic individual has a high probability of developing one or more of the diseases such as atopic dermatitis (AD), asthma and allergic rhinoconjunctivitis, and food allergies [1, 2]. Allergic march is used to express the natural course of atopic diseases. A baby born to atopic parents and carrying the genetic burden of atopy has the ability to respond and sensitize to allergens, it encounters from the 1 st days of its life. Usually, the first allergic disease to be seen is AD, followed by clinical findings of food allergy (FA). FA, which is present in most of the cases with AD, has an important role in the pathogenesis of the disease. In the later years of life, sensitivity to respiratory allergies develops, and bronchial asthma and allergic rhinitis (AR) findings are added to the table [3].
Eosinophilic Esophagitis: Association with atopic diseases and IgE mediated Food Allergy
Journal of Allergy and Clinical Immunology, 2019
RATIONALE: Eosinophilic Esophagitis (EoE) is a condition with an increasing frequency, i ts relevant studying natural evolution of allergic diseases, considering EoE as a part of these conditions METHODS: We performed a retrospective analysis of 71 EoE patients. The objective was to describe the frequency of atopies and IgE mediated food allergy. We evaluated demographics, EoE family history, symptoms onset, diagnosis age, IgE aeroallergen and food sensitization RESULTS: We found diagnosis mean of age was 18 yo (5-78 yo). Time between symptoms onset and EoE diagnosis was 2.86 years. We found male predominance 48/71 (67.70%). The most prevalent atopy was allergic rhinitis (49/71-69.01%), IgE-mediated food allergy (39/71-54.92%), allergic asthma (29/71-40.84%) and atopic dermatitis (12/71-16.90%). Between IgE-mediated food allergy patients, 71.79% presents anaphylaxis history. Eleven patients (15.49%) only have EoE. IgE food sensitization (26/71-36.61%) was more frequent than aeroallergen (5/71-7.04%), being 27 patients (38.02%) with dual IgE sensitization (food and aeroallergen), 26 only food sensitization, 5 only aeroallergen sensitizations. Thirteen patients (18.30%) didn't have any IgE sensitization. About the relationship between food allergy and EoE evolution, found that patients with IgE food reactions preceded the diagnosis of EoE 38/39 (97.43%) CONCLUSIONS: We observed high prevalence of atopic conditions. Food IgE sensitization was important despite most of our patients were adolescents and adults. It's important to follow up food worsening EoE even in older patients. In most cases of IgE mediated food allergies, anaphylaxis history warns us about the possibility that atopic patients that developed EoE could be associated with severe food allergy phenotype
Serum IgE levels and Total Eosinophil Count in Allergic Rhinitis
Journal of Islamic International Medical College, 2020
Materials and Methods: A total of 200 patients diagnosed clinically as 'Allergic Rhinitis', were selected by convenient sampling. Clinical diagnosis was made on the basis of history and complete ENT examination and findings recorded. Detailed history for intermittent or persistent symptoms of nasal congestion, watery rhinorrhea, nasal itching with sneezing and ocular symptoms as paroxysmal redness, itching and watering of eyes was taken. Detailed physical examination including complete ENT examination carried out and a record of presence of post nasal drip, hypertrophic pale or bluish boggy mucosa covered with thin secretion was made. Blood samples were taken for Serum IgE Levels and Total Eosinophil Count. The data was analyzed for frequencies by SPSS 24. Since the data was not parametric, non-parametric tests were applied. Results: Gender distribution showed a male predominance with males 58.5% (117) and females 41.5% (83). rd th Most of the patients were among the age group 3 to 5 decades. Serum IgE was raised in 152 (76%) patients, while Total Eosinophil Counts were raised in 104 (52%) patients. Serum IgE levels were found significant as p ≤ 0.50, while Total Eosinophil Count was not found significant as p ≥ 0.50. Conclusion: Serum IgE Levels and Total Eosinophil Counts are good reflector of Allergic Rhinitis. Although Serum IgE levels appear to be very significant in diagnosing Allergic Rhinitis, Total Eosinophil Count has yet to be established as a significant diagnostic tool. Being expensive tests, only Serum IgE levels should be advised in patients with suspicion of Allergic Rhinitis, and Total Eosinophil Count should not be advised routinely.
Scientific Reports
There is a profile of patient with eosinophilic oesophagitis and atopic background, marked by the existence of IgE-mediated sensitizations. Our aim is to report the observed sensitivities to environmental and food allergens and panallergens in patients with eosinophilic oesophagitis with atopic background as well as characterizing other markers or analytical parameters. We suspect that the prevalence of sensitization to panallergens will be high and this will probably be relevant in terms of the onset and clinical course of the disease. We collated clinical and analytical data from 160 adult patients with a reported diagnosis of eosinophilic oesophagitis. These patients were studied between 1 January 2012 and 31 December 2020. During an initial visit skin tests were performed with full batteries of routine aero-allergens and foodstuffs. Patients were subsequently referred for blood test and determination of specific IgE, blood count and total IgE (in all cases), as well as eosinophi...