The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
Gabriele Saretzki
EMBO reports, 2005
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A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest
Makoto T Hayashi
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p53 Prevents Entry into Mitosis with Uncapped Telomeres
Maria Thanasoula
Current Biology, 2010
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{"__content__"=>"Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16-deficient epithelial cells.", "sup"=>{"__content__"=>"INK4a"}}
laura tusell
Oncotarget, 2018
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Soothing the Watchman: Telomerase Reduces the p53-dependent Cellular Stress Response
Paul Yaswen
Cell Cycle, 2007
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Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA
Nicola Royle
The Journal of Cell Biology, 2007
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Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions
thao lai
Nature Communications, 2015
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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
Juana Flores
Genes & Development, 2009
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Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 Loss
Satya Narayan
Neoplasia, 2000
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Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA damage response
Kate Liddiard
NAR Cancer, 2021
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Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism
Özgün Özer
Oncotarget, 2018
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Telomere dysfunction alters the chemotherapeutic profile of transformed cells
Linda Cannizzaro
Proceedings of the National Academy of Sciences, 2001
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Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
Alexander Loewer
Molecular Biology of the Cell, 2012
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DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
Satya Narayan
British journal of cancer, 2001
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Massive Telomere Loss Is an Early Event of DNA Damage-induced Apoptosis
ELOISA HERRERA
Journal of Biological Chemistry, 2003
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Mitotic death: a mechanism of survival? A review
Mark Cragg
Cancer Cell International, 2001
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Connecting chromosomes, crisis, and cancer
richard maser
Science (New York, N.Y.), 2002
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Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy
Ana Preto
Oncogene, 2004
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Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
Paul Yaswen
Oncogene, 2003
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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
Lynda Chin
Cell, 1999
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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
Igor Roninson
Drug Resistance Updates, 2001
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Role of senescence and mitotic catastrophe in cancer therapy
Richa Singh
Cell Division, 2010
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TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts
Gabriele Saretzki
Mechanisms of ageing …, 2007
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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
Giulia Celi
Nature Cell Biology, 2005
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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
Makoto T Hayashi
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p53 suppresses structural chromosome instability after mitotic arrest in human cells
Bing Yu
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Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3
Kristi Helke
The Journal of biological chemistry, 2018
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Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts
Randeep Rakwal
Human Molecular Genetics, 2003
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