The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo (original) (raw)
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
Juana Flores
Genes & Development, 2009
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Targeting Assay To Study the cis Functions of Human Telomeric Proteins: Evidence for Inhibition of Telomerase by TRF1 and for Activation of Telomere Degradation by TRF2
Jean-Patrick Pommier
Molecular and Cellular Biology, 2002
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Targeting Assay To Study the cis Functions of Human Telomeric Proteins: Evidence for Inhibition of Telomerase by TRF1 and for Activation of Telomere Degradation by TRF2
Jean-Patrick Pommier
Molecular and Cellular Biology, 2002
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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
Guy Poirier
The EMBO Journal, 1997
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Increased p53 activity does not accelerate telomere-driven ageing
Juana Flores
EMBO reports, 2006
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Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts
Randeep Rakwal
Human Molecular Genetics, 2003
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Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes
Sara jaber
Cell Reports, 2013
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Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA
Nicola Royle
The Journal of Cell Biology, 2007
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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
Giulia Celi
Nature Cell Biology, 2005
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Cell death during crisis is mediated by mitotic telomere deprotection
Makoto T Hayashi
Nature, 2015
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Cellular senescence, cancer and aging: the telomere connection
Miguel Rubio
Experimental Gerontology, 2001
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XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
Juana Flores
Nature Genetics, 2005
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Telomeres, cell senescence and human ageing
Gabriele Saretzki
Signal Transduction, 2005
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Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 Loss
Satya Narayan
Neoplasia, 2000
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Significant Role for p 16 INK 4 a in p 53-Independent Telomere-Directed Senescence
Jacqueline J.l Jacobs
2004
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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
Lynda Chin
Cell, 1999
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Oxidative stress causes telomere damage in Fanconi anaemia cells – a possible predisposition for malignant transformation
Amiram Ravid
British Journal of Haematology, 2008
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TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis
Juana Flores
Molecular and Cellular Biology, 2009
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Telomere Shortening as Biological Hallmark of Cellular Senescence and Longevity-An Update
Faisal Gulzar
2023
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Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions
thao lai
Nature Communications, 2015
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TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts
Gabriele Saretzki
Mechanisms of ageing …, 2007
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Telomere dysfunction in ageing and age-related diseases
Fabrizio Di Fagagna
Nature Cell Biology, 2022
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Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency
Ying Luo
International journal of biological sciences, 2018
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Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2
Shuvra Shekhar Roy
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Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
Paul Yaswen
Oncogene, 2003
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Persistent telomere cohesion protects aged cells from premature senescence
Susan L Smith
2020
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TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization
T. Ingegnere
Nucleic Acids Research, 2015
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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
richard maser
Nature, 2003
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Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
Richard Hodes
Epigenetics & Chromatin, 2008
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The p53/p21WAF/CIP Pathway Mediates Oxidative Stress and Senescence in Dyskeratosis Congenita Cells with Telomerase Insufficiency
Frederick Goldman
Antioxidants & Redox Signaling, 2011
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Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage
Diego Megias
EMBO Molecular Medicine, 2015
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Massive Telomere Loss Is an Early Event of DNA Damage-induced Apoptosis
ELOISA HERRERA
Journal of Biological Chemistry, 2003
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Transcriptional activity of TRF2 is telomere length dependent
Suman Sengupta
2016
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p53 Differentially Inhibits Cell Growth Depending on the Mechanism of Telomere Maintenance
Chiara Caslini
Molecular and Cellular Biology, 2004
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Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells
James Garbe
Oncogene, 2005
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