Evaluation of Antipyretic Activity of Zizyphus Jujuba Lam. Leaves on Albino Rats (original) (raw)
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Objective: The objective of the study was to evaluate antipyretic activity of crude methanol extract of Zizyphus jujuba leaves. Z.jujuba commonly called, Red date or Chinese date or Bera (Pushto), belonging to family Rhamnaceae, is used primarily for its fruits. Jujube, a delicious fruit, is an effective herbal remedy improving stamina and muscular strength and aids weight gain, strengthens liver function and increases immune system resistance. Methodology: The anti-pyretic activity of methanolic extract of Zizyphus jujuba Lam leaves was evaluated to Brewer's yeast induced pyrexia in rats with respect to control group. Results: In the first hour, the antipyretic effect of methanol extract of Zizyphus jujuba (200 and 400 mg/kg) was significant (p<0.05, and p <0.01 respectively). The results suggests that Zizyphus jujuba at a dose of 200mg/kg caused a highly significant reduction at third hour (p<0.001). However, the effect increases significantly at the dose of 400 mg/kg having (p<0.01) at first, second and fourth hour. The antipyretic effect was comparable with that of a standard Paracetamol. Conclusion: The results of the study indicate that the MEZJ has better potential against Pyrexia which supports the traditional claims in folklore medicine. Phytochemical investigation suggests the presence of saponin in the leaves which may be responsible for the anti-ulcer activity.
Evaluation of antibacterial activity of Zizyphus jujuba
Journal of Pharmacognosy and Phytochemistry, 2020
Red date or Bera (Pushto), is used primarily for its fruits. Jujube, a delicious fruit, is an effective herbal remedy improving stamina and muscular strength and aids weight gain, strengthens liver function and increases immune system resistance. The aim of this study is to evaluate in-vitro efficacy of antibacterial activity of crude methanol, n-hexane, chloroform, ethyl acetate and aqueous extracts of Zizyphus jujuba against some human pathogenic bacterial strains. Antibacterial and antifungal activities of Zizyphus jujuba extract was carried out by using disc diffusion method. The crude methanol, n -hexane, chloroform, ethyl acetate and aqueous fractions showed 41.37, 44.82, 41.37, 55.17 and 44.82% activity against Enterobacter aerogenes respectively. The crude methanolic extract and n-hexane fractions were inactive against Escherichia coli, S. pneumoniae and Klebsella pneumonia respectively. From this study, the extracts namely n-hexane, ethyl acetate and aqueous extracts of Ziz...
Screening of Zizyphus jujuba for antibacterial, phytotoxic and haemagglutination activities
African Journal of …, 2011
Keeping in view this idea, the crude methanolic extract and various fractions of Zizyphus jujuba were screened for antibacterial, phytotoxic and haemagglutination activities. The n-hexane and aqueous fractions showed significant activity of 60 and 66.66% against Bacillus pumalis and Pseudomonas aerugenosa, respectively. Activity of ethyl acetate fraction was 65.38, 62.96, 62.96 and 72% against Staphylococcus epidermidis, Salmonella typhi, P. aerugenosa and B. pumalis, respectively. On the contrary, no activity of this fraction was recorded against Streptococcus pneumoniae. The crude, nhexane, chloroform, ethyl acetate and aqueous fractions showed 41.37, 44.82, 41.37, 55.17 and 44.82% activity against Enterobacter aerogenes, respectively. The crude methanolic extract and n-hexane fractions were inactive against Escherichia coli, S. pneumoniae and Klebsella pneumoniae, respectively. The ethyl acetate fraction was moderately phytotoxic against Lemna minor L at 1000 µg/ml. All the other fractions showed low phytotoxic activity at 1000 µg/ml. At 100 µg/ml, all the fractions showed low phytotoxic activity except crude methanolic extract, which was inactive. All the test samples were inactive at 10 µg/ml. All dilutions of the test samples showed no haemagglutination activity against any blood group.
Journal of Pharmaceutical Research, 2010
A high percentage of the people living in developing countries use traditional medicines including medicinal herbs to meet their primary health care needs for various ailments including heapatic damage. Traditionally, the fruits of Zizyphus jujube extract have been used in Indian and Chinese system of medicine to strengthen liver function. However, there is no scientific evidence for confirming the efficacy of this herb. Hence, present study was undertaken to evaluate the effect of methanolic extract of Zizyphus jujube fruit (MEZJ) on acute (0.5 ml/kg, p.o.) and chronic (0.2 ml/kg, p.o. twice weekly for eight weeks) models of liver injury induced by carbon tetrachloride (CCl 4) in rats. The MEZJ was administered orally at three different doses of 250 mg/kg, 500 mg/kg and 1000 mg/kg for eight weeks and ten days in chronic and acute models, respectively. The MEZJ (250 mg/kg, p.o.) significantly decreased levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin in serum and increased the same in LTH in the chronic model. In acute liver injury, MEZJ (250 mg/kg, p.o.) and MEZJ (500 mg/kg, p.o.) altered biochemical markers in both serum and LTH indicating hepatoprotective effect. The MEZJ (250 mg/kg, p.o.) also showed significant rise in SOD and catalase activities in both chronic and acute models, while MEZJ (500 mg/kg, p.o.) caused elevation in antioxidant enzyme activities only in the acute model. The histopathological studies supported the biochemical findings. It is concluded that MEZJ possess good hepatoprotective effect at doses of 250 and 500 mg/kg orally, whereas, 1000 mg/kg was found to be non-effective in preventing the hepatic damage.
2019
Introduction The instructions provided in traditional Persian medicine suggest that Iranians have been among the founders of medicine and have had a major role in the development of the science of medicine. Besides, the scientific transfer of traditional medical findings to modern medicine as part of a fully empirical-scientific process is one of the substantially important duties of the heirs of the medical history of Iran. Hence, since medicinal plants have been used by the public for a long time (1), the number of studies on the traditional applications of plants in the world, especially in the Mediterranean countries, has increased (2). According to the WHO report, the global sale of medicinal plants is currently about 62 billion dollars, which will increase to 5 trillion dollars by 2050 (3). Therefore, the examination of plants prevalently used in the traditional and classical medicine can be useful. For example, jujube is a plant with a long history of consumption as a fruit a...
Antibacterial activity of Zizyphus
2020
Red date or Bera (Pushto), is used primarily for its fruits. Jujube, a delicious fruit, is an effective herbal remedy improving stamina and muscular strength and aids weight gain, strengthens liver function and increases immune system resistance. The aim of this study is to evaluate in-vitro efficacy of antibacterial activity of crude methanol, n-hexane, chloroform, ethyl acetate and aqueous extracts of Zizyphus jujuba against some human pathogenic bacterial strains. Antibacterial and antifungal activities of Zizyphus jujuba extract was carried out by using disc diffusion method. The crude methanol, n -hexane, chloroform, ethyl acetate and aqueous fractions showed 41.37, 44.82, 41.37, 55.17 and 44.82% activity against Enterobacter aerogenes respectively. The crude methanolic extract and n-hexane fractions were inactive against Escherichia coli, S. pneumoniae and Klebsella pneumonia respectively. From this study, the extracts namely n-hexane, ethyl acetate and aqueous extracts of Zizyphus jujuba possess antibacterial activity
Comparative Clinical Pathology, 2019
Ziziphus spina-christi has been studied for various bioactivities but reports of its toxicity remain scanty. This study investigated the phytochemical content and toxicity of aqueous-methanol extract of Z. spina-christi seeds on hepatic and renal tissues of Wistar rats. The extract was screened for the presence of phytochemicals and orally administered to rats at 200, 600 and 1000 mg/kg bwt for 2 weeks. Haematological parameters and markers of the liver and kidney functions were evaluated as well as histoarchitecture. Tannins, saponins, alkaloids, flavonoids, phenols and glycosides were detected in the extract which significantly (P < 0.05) reduced levels of white blood cells, neutrophils, serum aspartate aminotransferase, Cl − , urea and creatinine. The extract also induced significant (P < 0.05) elevations in the levels of lymphocytes, platelets, direct and total bilirubin, albumin, alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, serum Ca 2+ , creatinine, urea and organ-body weight ratios. The levels of red blood cells, haemoglobin, packed cell volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, mean corpuscular volume, white blood cells, lymphocytes and neutrophils at 1000 mg/kg bwt, platelets at 200 mg/kg bwt, total protein, alkaline phosphatase at 200 mg/kg bwt, Na + and K + at all doses, as well as Ca 2+ at 600 and 1000 mg/kg bwt were not significantly (P > 0.05) affected. The extract caused hepatic vascular congestion and fibrosis at 600 and 1000 mg/kg bwt with no visible histoarchitectural effect on the kidney. The extract therefore possesses hepatotoxic and nephrotoxic activities. Care must be taken in the consumption of this plant for folklore medicine.
Phyto-Pharmacology of Ziziphus jujuba Mill- A Plant Review
2009
Herbs have always been the natural form of medicine in India. Medicinal plants have curative properties due to presence of various complex chemical substances of different composition which contain secondary metabolites such as alkaloids, flavonoids, terpenoids, saponin and phenolic compounds distributed in different parts of the plants. Ziziphus jujuba Mill, a member of the family Rhamnaceae, commonly known as Bor, is used traditionally as tonic and aphrodisiac and sometimes as Hypnotic-sedative and Anxiolytic, anticancer (Melanoma cells), Antifungal, Antibacterial, Antiulcer, Anti-inflammatory, Cognitive, Antispastic, Antifertility/contraception, Hypotensive and Antinephritic, Cardiotonic, Antioxidant, Immunostimulant, and Wound healing properties. It possesses allied compounds viz. Ascorbic acid, thiamine, riboflavin-bioflavonoids and Pectin A and various chemical substances like Mauritine-A; Amphibine-H; Jubanine-A; Jubanine-B; Mucronine-D and Nummularine-B. Sativanine-E. Frangu...
Revista Brasileira de Farmacognosia, 2013
The present study reports the anti-allergic activity of ethanolic extract of Zizyphus jujuba Mill., Rhamnaceae, and its possible mode of action. The effect of extract of Z. jujuba at different doses (250, 500 and 1000 mg/kg, orally) was simulated on studied animal models of asthma and allergy: a) milk induced eosinophilia and leukocytosis; b) compound 48/80 induced mast cell degranulation; and, c) active and passive cutaneous anaphylaxis. In addition, extract of Z. jujuba's effect on sensitized guinea pig ileum (ex vivo) and tracheal chain preparations (invitro) were investigated. Treatment with extract of Z. jujuba at all doses significantly: prevented the milk-induced eosinophilia and compound 48/80 induced degranulation of mesenteric mast cells; decreased passive cutaneous and active anaphylactic reactions. In addition, extract of Z. jujuba inhibited acetylcholine as well as histamine induced tracheal chain contraction, and also antigen induced contraction of sensitized guinea pig ileum (Shultz-Dale inhibition test). Furthermore, it exhibited also free radicals scavenging activity (in vitro). The observed anti-allergic and anti-anaphylactic activity of extract of Z. jujuba may be largely through the stabilization of mast cells by the membrane presence of phytoconstituents (steroidal saponins and flavonoids).
Study on Antipyretic Activity of Hibiscus rosa sinensis Leaves in Yeast Induced Pyrexia
Herbal drugs are being proved as effective as synthetic drugs with lesser side effects. Herbal Medicines are in line with nature, with less hazardous reactions. Pyrexia or Fever is defined as an elevation of body temperature. It is a response due to tissue damage, inflammation, malignancy or graft rejection. Antipyretics are drugs which can reduce elevated body temperature. The objective of the present work was to study the antipyretic activity of plant Hibiscus rosa sinensis Linn. belonging to family Malvaceae which is considered as an important medicinal family and known as "Mandharai" in Telegu and "Semparutti" in Tamil. The Whole plant of Hibiscus rosa sinensis are used as analgesic, antiviral, anti-convulatory, anti-tumor, juvenoid activity, antifertility, hypotensive, anti implantation, depressant, anti-inflammatory and antiestrogenic activity. The petroleum ether and methanolic extract was taken for the study and evaluated for antipyretic activity using Brewer's yeast induced pyrexia in Wister strain albino rats. The petroleum ether and methanolic extracts at a dose of 200 mg/kg and 400mg/kg were evaluated for antipyretic activity. The methanolic extract of Hibiscus rosa sinensis (MEHRS) plant showed a significant (P < 0.05) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. MEHRS have significant antipyretic activity when compared with the standard drug paracetamol. From the study, it concludes that the antipyretic activity observed can be attributed to the presence of flavonoids have been reported to exhibit antipyretic effect and therefore, supports the claims of traditional medicine as an antipyretic remedy.