Full-thickness porcine burns infected withStaphylococcus aureusorPseudomonas aeruginosacan be effectively treated with topical antibiotics (original) (raw)
Related papers
Alternative Treatment of Bacterial Wound Infections
Magazine of Al-Kufa University for Biology, 2022
Topical and systemic antibiotic treatment are essential in the prevention and treatment of wound infections. Systemic antibiotics, on the other hand, are strongly linked to mechanisms of resistance, which jeopardize the treatment process. The direction of systemic antibiotics to the eschar becomes less reliable the deeper the burn and the thicker the eschar becomes for local wound care (Noronha and Almeida, 2000). As a result, topical antibiotics appear as a viable treatment option, as they help to maintain a "high and sustained concentration of the antimicrobial at the infection site" (Cowling and Jones, 2017). Every year, wound treatment develops a high urgent clinical problem, as The requirement for wound care has an influence on a significant percentage of the global population. The system of healthcare in the United States spends $20 million a year on wounds (Jackson, 2006). An Incisional, acute, and chronic wounds are all examples of wounds that can become infected and lead to more complications. Incisional wounds and deep lacerations are often troublesome, and they account for a significant portion of the annual cost of wound healing products. While Wounds from incisions heal more quickly than chronic wounds, they always have challenges with appropriate closure as well as the formation of granulation tissue, which might lower one's quality of life. Wounds from incisions are also susceptible to infection, necessitating further care. Antiseptics, antibiotics, as well as silver dressings have traditionally is always used to treat wounds, however each of these therapies is ineffective against a wide range of microorganisms often present in wounds. However, if no appropriate clinical intervention is used, skin regeneration and overall healing time would be significantly slowed. While It's possible to use recombinant growth factors and tissue-engineered wound dressings, they are extremely costly and out of reach for the majority of illnesses (Shevchenko et al., 2010). In extreme burns, (SSD) silver sulfadiazine is the preferred transdermal substance, and it is almost universally used today over silver nitrate as well as mafenide acetate. Although SSD cream works excellent., it can effect recurrent side effects such as erythema multiforme, neutropenia, methemoglobinemia, and crystalluria (Hosnuter et al., 2004). As a result of this restriction, there has been an increase in interest in the development of a suitable biological wound care dressing that can provide the appropriate milieu for wound healing as well as protection during the process of healing. It possesses antifungal, antimicrobial, additionally antibacterial characteristics, which are particularly effective in wound care. It also increases the host's defenses to avoid infection. (Azuma et al., 2015). Several research groups around the world are
Preparing the wound bed 2003: Focus on infection and inflammation
Ostomy Wound Management, 2003
Wound bed preparation is the promotion of wound closure through diagnosis of the cause, attention to patient-centered concerns, and correction of systemic and local factors that may delay healing. To enhance the evidence base that may be lacking, a review of relevant literature was conducted and combined with input from the International Wound Bed Preparation Advisory Board and the Canadian Chronic Wound Advisory Board to create an updated examination of practices. A template based on expert opinion of the clinical actions corresponding to each step in the paradigm of preparing the wound bed is presented and the effects of local factors (tissue debridement, infection or inflammation, moisture balance, and edge effect [TIME]) are discussed. This review differentiates increased bacterial burden/infection in the superficial and deep wound bed compartments from inflammation and provides a topical approach to treatment. Inflammatory conditions causing leg ulcers, including pyoderma gangrenosum and vasculitis are reviewed. The topical combination of silver with absorptive dressings has led to new therapeutic options for increased bacterial burden in the surface wound compartment. A compilation of the available systematic reviews for the treatment of infection has been included as a background for the expert opinion.
Recent Advances in Wound Management
National journal of integrated research in medicine, 2015
New wound care technologies are being developed at an increasingly rapid pace in recent years. These innovations could significantly reduce the overall costs for treating complex and chronic wounds, while offering greater savings in preventing wounds and their recurrence. The ultimate goal of wound management is the prevention of wounds, or the halting of wound deterioration to achieve more rapid healing. This goal can only be accomplished by intervening with appropriate quality care, in a timely manner. Expenses related to wound care may include surgical and diagnostic procedures, pharmaceuticals, and fees for services provided by physicians and other healthcare professionals. Other costs include the use of medical equipment, the use of devices to provide compression or support for surfaces, wound closing, and the cost of skin care protection products, compression bandages, and changing dressings. Patients need access to the best standard of care to heal their wounds, prevent compl...
Advances in Wound Healing Products and Procedures: A Review
Victorious wound care involves optimizing patient's local and systemic conditions in combination with an ideal wound healing environment. Numerous products have been developed till date to influence this wound environment and to provide a pathogen-free, protected, and an area free from moisture for healing to occur in acceleration. Many novel products are being introduced to replace or augment various substrates in the wound healing cascade. With the abundance of available products, the goal is to find the most appropriate modality or combination of modalities to optimize healing. This review looks at the most modern applications of silver in microbial prophylaxis and treatment, including issues involving resistance and side effects, the latest uses of negative pressure wound devices, advanced dressings and skin substitutes, biologic wound products including growth factor applications, and hyperbaric oxygen as an adjunct in wound healing.
Recent Approaches for Wound Treatment
International Journal of Molecular Sciences
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Surgical Wound Bed Preparation of Chronic and Acute Wounds
Clinics in Plastic Surgery, 2007
Chronic wounds The current state of wound management Our aging population has presented us with many new challenges. One such challenge is the need to manage an increase in wound-related problems effectively and efficiently. There are obvious medical and economic motivations to accomplish this goal, because chronic wounds can impart an enormous burden on the patient, the health care provider, and the health care system. Over time, two parallel, yet divergent, management systems have developed. One strategy, used by medical specialists, uses a variety of dressings, topical enzymes, and local and systemic medications ultimately aimed at the promotion of healing by secondary intention or, in some cases, optimization of the wound for subsequent surgical reconstruction. In the second strategy, used by surgeons, early surgical intervention is used to prepare the wound for reconstruction in a timelier manner while promoting the healing process. This article reviews the development of these two distinct management systems and their areas of commonality and sets forth a new model to support the role of surgery in the treatment of problematic wounds.
Special Considerations in Wound Bed Preparation 2011
Advances in Skin & Wound Care, 2011
All authors, staff, and planners in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.
Journal of Orthopaedic Research, 2009
Despite the continuing advances in treatment of open fractures and musculoskeletal wounds, infection remains a serious complication. Current treatments to prevent infection utilize surgical debridement and irrigation, and high doses of systemic antimicrobial therapy. The aim of this work was to evaluate, in vitro, the potential of a fast-resorbing calcium sulfate pellet loaded with an antibiotic. The pellet could be used as an adjunctive therapy at the time of debridement and irrigation to reduce bacterial wound contamination. Small pellets containing a binder and calcium sulfate were engineered to resorb rapidly (within 24 h) and deliver high local doses of antibiotic (amikacin, gentamicin, or vancomycin) to the wound site while minimizing systemic effects. Results from dissolution, elution, and biological activity tests against P. aeruginosa and S. aureus were used to compare the performance of antibiotic-loaded, rapidly resorbing calcium sulfate pellets to antibiotic-loaded crushed conventional calcium sulfate pellets. Antibiotic-loaded rapidly resorbing pellets dissolved in vitro in deionized water in 12-16 h and released therapeutic antibiotic levels in phosphate buffered saline that were above the minimal inhibitory concentration for P. aeruginosa and S. aureus, completely inhibiting the growth of these bacteria for the life of the pellet. Crushed conventional calcium sulfate pellets dissolved over 4-6 days, but the eluates only contained sufficient antibiotic to inhibit growth for the first 4 h. These data indicate that fast-resorbing pellets can release antibiotics rapidly and at therapeutic levels. Adjunctive therapy with fast-acting pellets is promising and warrants further in vivo studies. ß