Improvement of Cancer Therapy by Nanotechnology (original) (raw)

Advances of Cancer Therapy by Nanotechnology

Cancer Research and Treatment, 2009

Recent developments in nanotechnology offer researchers opportunities to significantly transform cancer therapeutics. This technology has enabled the manipulation of the biological and physicochemical properties of nanomaterials to facilitate more efficient drug targeting and delivery. Clinical investigations suggest that therapeutic nanoparticles can enhance efficacy and reduced side effects compared with conventional cancer therapeutic drugs. Encouraged by rapid and promising progress in cancer nanotechnology, researchers continue to develop novel and efficacious nanoparticles for drug delivery. The use of therapeutic nanoparticles as unique drug delivery systems will be a significant addition to current cancer therapeutics.

Cancer nanotechnology: application of nanotechnology in cancer therapy

2010

The application of nanotechnology for cancer therapy has received considerable attention in recent years. Cancer nanotechnology (an interdisciplinary area of research in science, engineering and medicine) is an upcoming field with extensive applications. It provides a unique approach and comprehensive technology against cancer through early diagnosis, prediction, prevention, personalized therapy and medicine. Target-specific drug therapy and methods for early diagnosis of pathologies are the priority research areas in which nanotechnology would play a vital part. This review focuses on the approaches of cancer nanotechnology in the advancement of cancer therapy.

Nanotechnology of Cancer Therapy: An Overview

Current Research in Pharmaceutical Sciences, 2017

Nanotechnology is the study and use of structures between 1 nanometer and 100 nanometers in size. Nanotechnology is definitely a medical boon for diagnosis, treatment and prevention of cancer diseases. Nanoparticulate technology is of particular use in developing a new generation of more effective cancer therapies capable of overcoming many biological, biophysical and biomedical barriers that the body stages against a standard intervention. Nanoparticles that deliver chemotherapy drugs directly to cancer cells are under development. Nanomedicine application areas include drugdelivery, therapy, diagonistic, imaging and antimicrobial techniques. The formed nano particles can be used in wide range of therapeutic treatment of cancer. To overcome problems of systemic toxicity associated with chemotherapy and enhance treatment resolution of cancer therapies, nanotechnology is increasingly providing many novel approaches, especially to energy-based cancer therapies. Nonmaterial and biomarkers of cancer, general principle of drug targeting to cancer, intracellular mechanisms, and nanoparticles based formulation in market, several recent applications in medicine as diagnostic and therapeutic are discussed. This article aim to overview on all the parts of nanotechnology in cancer therapy.

Application of Nanotechnology in Cancer Treatment

Research Journal of Pharmacy and Technology, 2012

The application of nanotechnology for cancer therapy has received considerable attention in recent years. Cancer nanotechnology is an upcoming field with extensive applications in science, medicine and engineering. It provides a unique approach and comprehensive technology against cancer through early diagnosis, prediction, prevention, personalized therapy and medicine. Target-specific drug therapy and methods for early diagnosis of pathologies are the priority research areas in which nanotechnology would play a vital part. This review focuses on the approaches of cancer nanotechnology in the advancement of cancer therapy.

Cancer Nanotechnology: The Recent Developments in the Cancer Therapy

Global Journal of Nanomedicine, 2016

The nanotechnology is prominent in medicine for various applications. Nanotechnology is a multidisciplinary field, which covers diverse arrays of devices made using principles of engineering, biology, physics, and chemistry. The increasing number of nanomedicines is approved clinically, used safely, which highlights the important role of nanotechnology in the field of cancer research. The successful application of nanotechnology to the targeted smart drug therapy ISA rapidly growing component of armamentarium against cancer. Nanotechnology is being applied to cancer in two broad areas: the development of nanovectors, such as nanoparticles, which can be loaded with drugs or imaging agents and then targeted to tumors, and high throughput nanosensor devices for detecting the biological signatures of cancer. This advanced technology provides a unique approach and comprehensive technology against cancer through early diagnosis, prediction, prevention, personalized therapy, and medicine. This review focuses on nanotechnology-based clinical approaches in the advancements of cancer therapy.

NANOTECHNOLOGY: AN EMERGING TOOL FOR EFFECTIVE CANCER TREATMENT

ARTICLE INFO ABSTRACT Nanotechnology is rapidly progressing and is being implemented to solve the problems related to conventional chemotherapeutic agents such as low safety margin, poor water solubility, poor oral availability, normal tissue toxicity and tumor resistance. Nanotechnology promises targeted delivery of drugs and significant improvement in cancer diagnosis, treatment and management. Nanoparticle assisted combination therapies promotes synergism, enhances therapeutic effectiveness, improves pharmacokinetics and suppresses drug resistance. This review sheds light on various nanotechnological platforms as anticancer drug delivery vehicles, raises awareness of the advantages of therapeutic applications of anticancer agents using nanoparticles, minimizing the normal tissue toxicity, drug resistance and treatment of disseminated metastatic cells through targeted therapy.

Nanotechnology based approaches in cancer therapeutics

Advances in Natural Sciences: Nanoscience and Nanotechnology, 2014

The current decades are marked not by the development of new molecules for the cure of various diseases but rather the development of new delivery methods for optimum treatment outcome. Nanomedicine is perhaps playing the biggest role in this concern. Nanomedicine offers numerous advantages over conventional drug delivery approaches and is particularly the hot topic in anticancer research. Nanoparticles (NPs) have many unique criteria that enable them to be incorporated in anticancer therapy. This topical review aims to look at the properties and various forms of NPs and their use in anticancer treatment, recent development of the process of identifying new delivery approaches as well as progress in clinical trials with these newer approaches. Although the outcome of cancer therapy can be increased using nanomedicine there are still many disadvantages of using this approach. We aim to discuss all these issues in this review.

NANOTECHNOLOGY FOR CANCER THERAPY: RECENT DEVELOPMENTS

This paper is an overview of advances and prospects in applications of nanotechnology for cancer treatment. Nanotechnology is an use for prevention, diagnosis, and treatment .nanotechnology offer a promise for the targeted delivery of drugs, genes and protein to tumer tissue and therefore alleviating the toxicity of anticancer agent in healthy tissues. Cancer is one of the leading causes of death worldwide. Deaths from cancer are continuously rising worldwide with a projection of about 12 million deaths from cancer in 2030. . Nanotechnology is one of the most rapidly growing fields in the 21st century. Many different types of nanosystems have been utilized in diagnostics and therapeutics of various diseases. To subside the disadvantages of conventional cancer therapeutics, nanotechnology has been given considerable attention. In this paper, the current nanotechnologies that can be utilized in oncological interventions will be discussed. These mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics. It is demonstrated how nanotechnology can help solve one of the most challenging and longstanding problems in medicine, which is how to eliminate cancer without harming normal body tissue. This article review current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, carbon nanotubes,superparamagnetic nanoparticles and nuclear acid base nanoparticle [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO) ] as well as nanotechnologies for combination therapeutics strategies, for example, nanotechnologies combined with multidrug-resistance modulator, ultrasound, hyperthermia, or photodynamic therapy. The review increases awarnes of advantages in cancer therapy.

Nanotechnology for cancer treatment

Nanotechnology Reviews, 2014

Nanotechnology has the potential to increase the selectivity and potency of chemical, physical, and biological approaches for eliciting cancer cell death while minimizing collateral toxicity to nonmalignant cells. Materials on the nanoscale are increasingly being targeted to cancer cells with great specificity through both active and passive targeting. In this review, we summarize recent literature that has broken new ground in the use of nanotechnology for cancer treatment with an emphasis on targeted drug delivery.

Nanotechnology in cancer therapy

Journal of Drug Targeting, 2013

Cancer is one of the major causes of mortality worldwide and advanced techniques for therapy are urgently needed. The development of novel nanomaterials and nanocarriers has allowed a major drive to improve drug delivery in cancer. The major aim of most nanocarrier applications has been to protect the drug from rapid degradation after systemic delivery and allowing it to reach tumor site at therapeutic concentrations, meanwhile avoiding drug delivery to normal sites as much as possible to reduce adverse effects. These nanocarriers are formulated to deliver drugs either by passive targeting, taking advantage of leaky tumor vasculature or by active targeting using ligands that increase tumoral uptake potentially resulting in enhanced antitumor efficacy, thus achieving a net improvement in therapeutic index. The rational design of nanoparticles plays a critical role since structural and physical characteristics, such as size, charge, shape, and surface characteristics determine the biodistribution, pharmacokinetics, internalization and safety of the drugs. In this review, we focus on several novel and improved strategies in nanocarrier design for cancer therapy.