A Rare Case of Carcinoma of Ovary with Carcinoma of Cervix (original) (raw)

A Rare Case of Synchronous Ovarian Adenocarcinoma and Squamous Cell Carcinoma of Cervix

European Journal of Medical and Health Sciences, 2021

Synchronous tumours of gynaecological malignancies occur rarely and most of these cases are represented by synchronous ovarian and endometrial cancer. Synchronous malignancies of cervix and ovary are rare with poor prognosis. Only few cases of synchronous cancer of cervix and ovary are found in the literature as case reports. Here, we report a case of a 63 year old patient who was diagnosed with synchronous squamous cell carcinoma of cervix and high grade serous carcinoma of ovary in which her clinical presentation, investigation and intraoperative findings were atypical. Patient presented with postmenopausal bleeding and mass per abdomen. Pipelle sampling revealed squamous cell carcinoma of cervix. Examination under anaesthesia noted endocervical growth measuring 3×4 cm with endoluminal extension into the whole endometrial cavity. Computerized tomography (CT) imaging showed left ovarian mass measuring 10.0×11.7 cm. Uterine corpus involvement in this case mislead us to the initial d...

Synchronous Primary Carcinomas of Cervix and Ovary: A Case Report

IOSR Journal of Dental and Medical Sciences, 2016

Synchronous tumors occur rarely in female genital tract, though it is one among potential sites for synchronous malignancies. In our case report a 36 year old female is diagnosed with two primary malignancies simultaneously; squamous cell carcinoma cervix and bilateral papillary cystadenocarcinoma ovary. Their distinct histological features and sparing of uterine corpus and fallopian tube helped in establishing the diagnosis as two separate primaries rather as metastatic spread of one primary malignancy. The objective is to strengthen the suggestion of thorough evaluation of whole female genital tract in case of suspected tumor, as secondary Mullerian system theory explains the possibility of synchronous cancer in female genital tract.

Four synchronous female genital malignancies: the ovary, cervix, endometrium and fallopian tube

Archives of gynecology and obstetrics, 2008

To present a unique case of a 63 year-old woman with coexistent adenocarcinoma of the ovary, endometrium, cervix and fallopian tube. A case report from a tertiary health center. A woman presenting with postmenopausal bleeding and abdominal distantion was assessed by endometrial biopsy and explorative surgery. The frozen section of the mass on the right adnex revealed malign mucinous carcinoma of the ovary. As usual, optimal debulking was performed as initial surgical staging procedure of ovarian cancer. The microscopic examination of the right ovary revealed a typical mucinous cystadenocarcinoma. Furthermore, the focal endometrial irregularity at the left uterine cornus turned out to be a well differentiated endometrial carcinoma of the endometrioid type with <1/3 myometrial invasion. The pale infiltrative lesion in the cervix also turned out to be an adenocarcinoma of the endocervical type with deep stromal invasion and areas of diffuse glandular dysplasia and in-situ glandular ...

Triple Synchronous Primary Malignancies of Ovary, Endometrium and Cervix – A Rare Case Report

Journal of Medical Science And clinical Research, 2018

Synchronous primary malignancies of the female genital tract are rare. Of the reported cases, the more common synchronous cancers are those involving the ovary and endometrium. Three primary malignancies occurring simultaneously are even fewer. We found only 14 such reported cases in pub-med indexed journals till date. The single most important criterion to call these neoplasms synchronous malignancies is that they should be histologically distinct and separated from each other by normal intervening tissues, with no evidence of metastasis. The prognosis for synchronous tumors is relatively better as concurrent tumors are detected early and are associated with a low histological grade. We are presenting a case report of a 36 year old woman who underwent surgery for complex left ovarian cyst. Intra-operative frozen section analysis of the ovarian cyst proved to be positive for malignancy. Histopathological examination of subsequent staging laparotomy specimen revealed co-existing small cell carcinoma of the ovary, well differentiated endometrioid adenocarcinoma of endometrium, and squamous cell carcinoma-in-situ of the cervix. To the best of our knowledge, simultaneous presentation of these three distinct histological patterns of gynaecological malignancies has not been reported earlier.

Hidden Synchronous Cervical Malignancy in a Case of Ovarian Cancer

Journal of Gynecologic Surgery, 2014

Background: Synchronous primary malignancies of the female genital tract constitute 1.7% of all genital malignancies. Case: A 45-year-old, para 5, woman presented with loss of appetite and abdominal distention. A provisional diagnosis of an ovarian malignancy was made. Final histopathology of the specimen revealed the presence of an ovarian papillary serous cystadenocacinoma with a cervical leiomyosarcoma. She received chemotherapy. Results: As of this writing, this patient is being followed. Conclusions: The coexistence of primary neoplasms in the ovary and cervix are rare. An organ that appears to be normal may have a hidden malignancy. Thus, every surgical specimen should be subjected to detailed histopathologic examination. In addition, the possibility of a synchronous malignancy elsewhere in the body should be kept in mind while working to address a genital malignancy. (J GYNECOL SURG 30:219

Synchronous Primary Ovarian and Endometrial Cancers

Obstetrics & Gynecology, 2009

Synchronous primary ovarian and endometrial cancers are quite unusual based on our previous experience . Confirmative diagnosis depends on the pathologic recognition of different histologic patterns. Although some researchers have tried to determine the underlying mechanisms for the development of synchronous tumors using advanced molecular or clonal analysis, the etiologies of such tumors remain unclear . A recently proposed hypothesis suggests that the etiology of synchronous cancers is related to the embryologically similar organs that develop synchronous neoplasms when they are simultaneously subjected to carcinogens.