Salivary tumors in north Jordanians: A descriptive study (original) (raw)
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Salivary Gland Tumors in an Iranian Population: A Retrospective Study of 130 Cases
Journal of Oral and Maxillofacial Surgery, 2007
Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia. In the absence of epidemiologic studies of these neoplasms in an Iranian population, we conducted a preliminary survey of 130 cases over the last 20 years in Hamedan, Iran. Patients and Methods: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003. This review found 89 patients with benign tumors and 41 patients with malignant tumors. The collection of data included gender, age, location, and histopathology of the tumor. Other recorded data included diagnostic procedures, operative reports, complications, additional treatment, and follow-up. Results: We studied 78 females and 52 males with a mean age of 44.9 years. Patients with benign and malignant tumors presented with a mean age of 41.3 and 47 years, respectively. The frequency of benign tumors was 68.4% (n ϭ 89) and 31.6% for malignant tumors (n ϭ 41). Tumors were localized in the parotid gland (63%; n ϭ 82), the submandibular gland (23%; n ϭ 30), and in the minor salivary glands (14%; n ϭ 18). The most common benign tumor was pleomorphic adenoma (65.4%; n ϭ 85). Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n ϭ 15), followed by adenocarcinoma (10%; n ϭ 13). Greater than 63% of malignant tumors were treated surgically, and the remaining with combined therapy. Seven patients died over the follow-up period (6 with persistent disease), 5 were lost to follow-up, and 23 remained cancer-free. Conclusion: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously. In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.
Pathology Research International, 2011
Tumors of the salivary glands are uncommon head and neck neoplasia. We conducted a retrospective study of 392 cases over the last 6 years in Shiraz, south of Iran, to investigate the clinicopathological features of these tumors in Iranian population. The age of the patients ranged from 8 to 85 years, with the mean age 44.57 ± 14.65 years and male-to-female (M : F) ratio was 1.02 : 1. For benign tumors, there was a propensity towards females, whereas the malignant tumor was more common in males. The ratio of benign tumors to malignancies was 2.19 : 1. Pleomorphic adenoma (PA) was the most common tumor and accounted for 85% of all benign tumors, followed by Warthin's tumor (8.6%). Of the 125 malignancies, adenoid cystic carcinoma (40%), mucoepidermoid carcinoma (24%) and invasive squamous cell carcinoma (16%) were the most common histological types. Most of the salivary gland tumors (75%) originated from major salivary glands and the remained (25%) originated from minor glands. The parotid gland was the most common site both in benign and malignant tumors. Most of our findings were similar to those in the literature, with some variations. The salivary tumors slightly predominated in males. Adenoid cystic carcinoma and mucoepidermoid carcinoma constituted the most common malignancies.
Salivary gland tumors: a 15- year report from iran
Turkish Journal of Pathology, 2015
Objective: The aim of this study was to document the clinicopathologic characteristic of salivary gland tumors in Tehran, Iran, over a 15-year period. Material and Method: a retrospective study was conducted on salivary gland tumors diagnosed at two pathology centers of Shahid Beheshti University of Medical Sciences from March 2000 to March 2015. Patient age, sex, tumor site and frequency, as well as clinical and radiographic features and histopathologic diagnosis constituted the main analysis outcome measures. Results: Of the 45429 biopsies conducted over 15 years, 6065 (13.3%) cases were oral and maxillofacial lesions and 937 (15.4%) of these had tumoral diagnoses. Of the 937 tumoral cases, 184 (19.6%) were salivary gland tumors and among 184 cases, 65 (35.3%) were benign and 119 (64.7%) were malignant. Pleomorphic adenoma was the most frequently occurring tumor, comprising 32.6% of all tumors, followed by mucoepidermoid carcinoma (27.1%) and adenoid cystic carcinoma (22.2%). Tumors were frequently reported in minor salivary glands (75%), particularly in the palate with 89 (48.4%) cases. The peak ages of incidence were the fourth and sixth decades of life. Malignant salivary gland tumors showed a predilection for females (72.9%), which was statistically significant (P<0.01). Conclusion: The data presented herein are similar to previously published reports in other countries and other areas of Iran. however, some differences were observed in our study, such as higher overall frequency, a lower mean age of patients with malignant tumors, and the particular sites of involvement. These differences can be attributed to racial factors, the pathology centers of sample collection, and the duration of the studies.
Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population
Shiraz E-Medical Journal, 2021
Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pl...
Salivary gland tumors: a 15-year experience of a universıty hospital in Turkey
Northern Clinics of Istanbul
T he salivary glands consist of three major glands as parotid, submandibular and sublingual glands and hundreds of minor glands, which are diffusely located in the beginning part of the respiratory system. Tumors of the salivary glands are rarely encountered. However, they appear with different histopathological characters. Different biological behaviors can be observed even in neoplasms defined by the same name. In the latest classification made by the World Health Organization (WHO) in 2017, salivary gland tumors were classified into more than 30 benign and malignant histologic subtypes [1]. This wide histopathological spectrum and significant differences in prognosis between them distinguish salivary gland tumors from other organ neoplasms. Salivary gland tumors account for approximately 3-4% of all head and neck tumors [2]. Their inci-ABSTRACT OBJECTIVE: To determine the demographic characteristics of benign and malignant salivary gland tumors in our department in the last 15 years. METHODS: In this study, the files of the patients who underwent salivary gland surgery between 2004 and 2019 in our department were analyzed retrospectively. A total of 366 patients whose diagnoses of salivary gland tumor histopathologically confirmed were included in this study. The demographic data of the patients and tumor localizations were recorded, and their relationships with histopathological results were examined. RESULTS: Of the 366 tumors, 292 (80%) of them was originated from the parotid gland, 52 (14%) from the submandibular gland, and 22 (6%) from the minor salivary gland. The male: female ratio was found as 1.2:1, and the mean age of the patients was 50.37 years. A total of 259 (70.8%) tumors were benign, and 107 (29.2%) were malignant. The most frequent benign tumor was pleomorphic adenoma, with 121 cases (46.7%). While pleomorphic adenomas constituted the majority of the benign tumors of the submandibular gland and minor salivary glands, Warthin tumor was detected more than pleomorphic adenoma in the parotid gland. The most common malignant tumor was mucoepidermoid carcinoma, with 26 cases (24.3%). CONCLUSION: The distribution of the salivary gland tumors detected in our department was found to be substantially similar to other worldwide series. Unlike the literature, we concluded that salivary gland tumors were seen slightly more in males, minor salivary gland tumors were relatively rare and Warthin tumors were more frequently detected in our region.
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: Salivary gland tumours constitute 3-4% of all head and neck cancers (mostly benign). These tumours are epithelial (95%) or mesenchymal in origin. Pleomorphic adenoma is the most common benign salivary gland tumour and mucoepidermoid carcinoma (45%) is the most common malignant salivary gland tumour followed by adenoid cystic carcinoma (30%). The parotid, submandibular and the minor salivary glands of palate are commonly involved and the sublingual gland is rarely affected.Methods: Hospital based cross sectional study was done in a tertiary care centre during a period of 1 year, which included 21 patients (10 men and 11 women). Patients were analysed according to age, gender, food habits, histopathological type and site of the tumour and treatment strategy.Results: All the cases were from upper Assam province sharing a particular demographic pattern between 19-65 years. Peak incidence in males was fourth decade and females was third decade. Male female ratio was 0.9:1. Ou...
Tumours of Salivary Glands in Sudan
International Journal of Otorhinolaryngology, 2018
Benign and malignant tumors are rare conditions; it was not uncommonly occurs in salivary glands and usually presented as a painless mass. The presence of pain and facial nerve palsy may indicate malignant transformation. Diagnosis is made by imaging and biopsies. Objectives: This study aims to know the pattern of Benign and malignant tumors in salivary glands among Sudanese patients in Khartoum state according to many categories age, gender, clinical presentation and diagnosis. Methods: This is retrospective, cross-sectional, analytic and hospital based study from January 2014 to May 2016. Conducted in Otorhinolaryngological, Head and neck and Oral Maxillofacial hospitals in Khartoum state in Sudan. Results: The highest percentage of neoplasm is benign more commonly as pleomorphic adenoma in minor glands. Malignant tumor is commonly affected the parotid glands of predominance in adenoid cystic carcinoma followed by mucoepidermoid carcinoma. Conclusion: Benign and malignant tumors which occur in salivary glands were commonly pleomorphic adenoma and adenoid cystic carcinoma respectively.
Salivary gland neoplasms: an analysis of 74 cases
Journal of Maxillofacial and Oral Surgery, 2009
cases of salivary gland neoplasms were analyzed retrospectively, of which 44 (60%) were benign and 30 (40%) malignant. 61 % percent of neoplasms were in the parotid gland, 22% in the minor salivary glands including sublingual salivary glands, and 17% in the submandibular glands. The most common benign neoplasm was pleomorphic adenoma (64%), and the most common malignant neoplasm were adenoid cystic carcinoma (17%) and mucoepidermoid carcinoma (23%).We analyze the incidence and distribution of all types of salivary gland neoplasms in our series, and provide data for comparison with other epidemiological studies from different geographical sites and races. Demographic data from these studies help us to a better understanding of the biological and clinical characteristics of the disease. Further epidemiological surveys should be encouraged for better understanding of the disease and to provide early and better treatment of salivary gland neoplasms
Neoplasms of the salivary glands in a Turkish adult population
Medicina Oral Patología Oral y Cirugia Bucal, 2010
Objective: This retrospective study aimed to investigate the types and distribution of neoplasm of salivary glands in a Turkish population. Study Design: The histological diagnosis records of the Department of Pathology at Cumhuriyet University were reevaluated for 125 patients who were treated for salivary gland tumors from 1987 to 2008. The neoplasms were analyzed for histological diagnosis, age, sex, and site. The histological diagnoses were analyzed according to the 2005 WHO classification. Results: A total of 125 primary salivary gland neoplasms, consisting of 95 (76%) benign and 30 (24%) malignant groups were recorded. The most common major and minor salivary gland sites were the parotid (61.6%) and palatal glands (9.6%), respectively. Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor. Among the malignant group, adenoid cystic carcinoma was the most prevalent. Age for all cases ranged from 16-80 years; mean age was 41.97 years, with a female to male ratio of 1:1.15. Conclusions: Although there were some discrepancies, the characteristics of salivary gland tumors of Turkish patients are in line with those of patients from other countries according to tumor type, tumor site distribution, and age and sex of patients.