Chemical Constituents of Sechium edule (Jacq.) Swartz (original) (raw)
Related papers
Journal of chemical and pharmaceutical research, 2015
The objectives of this research were to study antio xidant activities from various fruit extracts of th ree organs of S. edule using two methods of antioxidant assays which were DPPH (2,2-diphenyl-1-picrylhydrazyl) and CUPR AC (Cupric ion Reducing Antioxidant Capacity) and corr elation of their total flavonoid, phenolic and caro tenoid content with IC50 of DPPH antioxidant activities and EC 50 of CUPRAC capacities. Extraction was performed by reflux apparatus using different polarity solvents. The extracts were evaporated using rotary evaporat or. Antioxidant capacities were tested using DPPH and C UPRAC assays. Determination of total phenolic, flav onoid and carotenoid content was performed by spectropho tometer UV-visible and their correlation with IC 50 of DPPH scavenging capacities and EC 50 of CUPRAC capacities were analyzed by Pearson’s me thod. Ethyl acetate pedicel extract of S. edule (PD2) had the lowest IC 50 of DPPH scavenging activity 1.3 μg/ml, while ethyl acetate fruit...
A Brief Review on Sechium edule
International Journal of Pharmaceutical Sciences Review and Research
Medicinal plants play a key role in development of effective medicines for the variety of disease. The use and potency of medicinal plants remarkably contribute to the disclosure of their therapeutic properties. Nowadays the significance of plant-based medicines has gained importance all the world. Varieties of herbs are exposed for the phytochemical screening for the separation of bio-active molecules which are pharmacologically evaluated and has come up with the discovery of new drugs. Sechium edule is an herbaceous plant which belongs to family Cucurbitaceae, and commonly called as chayote, chow-chow, and mirliton. Sechium edule has acquired widespread consuming acceptance and appreciated by its nutritional, phytochemical and pharmacological properties. This herb has proven to treat variety of diseases including asthma, bronchitis, cancer, constipation, diabetes, jaundice etc. they are rich in several important amino acids and phytoconstituents such as alkaloids, flavonoids, saponins, sterols, minerals and vitamins.
Extracts and Fractions from Edible Roots of Sechium edule (Jacq.) Sw. with Antihypertensive Activity
Evidence-Based Complementary and Alternative Medicine, 2014
Sechium edule is traditionally used in Mexico as a therapeutic resource against renal diseases and to control high blood pressure. The purpose of this work is to evaluate the antihypertensive effect of the hydroalcoholic extract obtained from the roots of this plant, including its fractions and subfractions, on different hypertension models induced with angiotensin II (AG II). The hydroalcoholic extract was tested on an in vitro study of isolated aorta rings denuded of endothelial cells, using AG II as the agonist; this assay proved the vasorelaxant effect of this extract. Vagotomized rats were administered different doses of AG II as well as the Hydroalcoholic extract, which reduced blood pressure in 30 mmHg approximately; subsequently this extract was separated into two fractions (acetone and methanol) which were evaluated in the acute hypertension mouse model induced with AG II, where the acetone fraction was identified as the most effective one and was subsequently subfractioned using an open chromatographic column packed with silica gel. The subfractions were also evaluated in the acute hypertension model. Finally, the extract, fraction, and active subfraction were analyzed by MS-PDA-HPLC, identifying cinnamic derivative compounds like cinnamic acid methyl ester.
Phenolic Acid and Flavonoid Patterns in Twelve Sechium edule Varieties
2021
Fruit pulp of twelve Sechium edule Indian accessions were analyzed for phenolic acid and flavonoid constituents. The quantitative evaluation was performed using liquid chromatography mass spectrophotometer method, which showed significant differences in the composition of phenolic acids and flavonoids among accessions. Vanillic acid was the predominant phenolic acid in most of the accessions ranging from 269.28 to 4080.82 μg/g. High amounts of vanillic acid in accession SEC-11 (4080.82 ± 130.92 μg/g) and SEC-06 (1825.46 ± 24.54 μg/g), protocatechuic acid (1736.59 ± 94.90 μg/g) in SEC-09 and syringic acid (1676.97 ± 70.35 μg/g) in SEC-20 was detected respectively. The highest amount of flavonoid present was catechin in the accessions SEC-36 (75.83 ± 4.37 μg/g) followed by SEC-20 (19.43 ± 0.64 μg/g). Data were analyzed using principal component analysis method and the obtained scoring plot showed that all nine accessions had formed one cluster. Discrimination of metabolic profiles of different S. edule accessions using principal component analysis showed that accessions grouping was consistent with the LC-MS results obtained. This method of estimation of metabolites can be successfully employed enabling genetic grouping of S. edule accessions in an effective manner for breeding studies.
Molecules
In addition to their own antioxidants, human cells feed on external antioxidants, such as the phenolic compounds of fruits and vegetables, which work together to keep oxidative stress in check. Sechium edule, an edible species of chayote, has phenolic compounds with antioxidant activity and antineoplastic activity. A Sechium hybrid shows one thousand times greater antineoplastic activity than edible species, but its antioxidant and anti-inflammatory activities and the content of phenolic compounds are unknown. The aim of this study was to determine the antioxidant and anti-inflammatory capacity of the extract of fruits of the Sechium hybrid in vitro and in vivo. Phytochemical analysis using HPLC showed that the extract of the Sechium hybrid has at least 16 phenolic compounds; galangin, naringenin, phloretin and chlorogenic acid are the most abundant. In an in vitro assay, this extract inhibited 2,2-diphenyl-L-picrylhydrazyl (DPPH) activity and protected the dimyristoylphosphatidylet...
Molecules
Chayote leaves are known for culinary and traditional medicine applications. This work intended to recover carotenoids and phenolic compounds from chayote leaves using the ultrasound-assisted extraction (UAE). A Box–Behnken design was employed to investigate the impact of extraction time, temperature, and ultrasonic power on the recovery of total carotenoids, total phenolic compounds, and antioxidant activities. For comparative purposes, chayote leaf extracts were prepared by maceration (ME) and microwave-assisted extraction (MAE), using the same time and temperature conditions optimized by UAE. Extraction at 50 °C and 170 Watts for 30 min provided the optimal UAE conditions. UAE showed better extraction efficacy than ME and MAE. The HPLC analysis of the extracts showed that the xanthophyll class was the main class of carotenoids, which constituted 42–85% of the total carotenoid content, followed by β-carotene and tocopherol. Moreover, 26 compounds, classified as phenolic acids, fla...
International journal of pharmaceutical sciences review and research, 2023
Sechium edule, known as Chayote, belongs to the Cucurbitaceae family. It is also grown worldwide in tropical and subtropical regions. Because of its medicinal benefits, Chayote is being used as a traditional medicine in different areas of the northeast. Chayote fruit and vegetables show practical components people use in their regular diet. The current review revealed that the plant's edible parts could be used to treat different illnesses due to the presence of other secondary metabolites. The plant has also been shown to possess several pharmacological properties. The toxicological report in the present review also documented that the plant Sechium edule does not contain any neurotoxic or genotoxic metabolites, which will contribute to the toxicological information. Different parts of the plant, such as young stems and seeds, are also consumed in various forms due to the presence of proteins and vitamins. The plant has also shown high contents in aspartic, glutamic acid, alanine, proline, serine and valine which recommends that the plant can offer medicinal benefits and be used in hospital diets.
Scientific Reports, 2021
Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different variables: five morphological, 19 biochemical, anti-proliferative activity of extracts on five malignant cell lines, and 188 polymorphic bands of amplified fragment length polymorphisms, were used in order to identify the most relevant variables for the design of genetic interbreeding. Significant relationships between morphological and biochemical characters and anti-proliferative activity in cell lines were obtained, with five principal components for principal component analysis (SAS/ETS); variables were identified with a statistical significance (< 0.7 and Pearson values ≥ 0.7), with 80.81% of the accumulation of genetic variation and 110 genetic bands. Thirty-nine (39) variables were recovered ...
Antimicrobial Activity of Nine Extracts of Sechium edule (Jacq.) Swartz
Microbial Ecology in Health & Disease, 2003
The antimicrobial properties of Sechium edule (Jacq) Swartz alcoholic extracts obtained according to the Farmacopea Argentina (6th edn) were tested against bacteria of clinical relevance as nosocomial pathogens. To evaluate antibacterial activity, the disc diffusion assay was carried out with several gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus pyogenes, Streptococcus agalactiae, Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212). This assay was suitable for the screening of a large number of extracts at one time. All ethanolic extracts showed activity against gram-positive bacteria. Minimal inhibitory concentration (MIC) values were determined with a microdilution assay. The highest activity was obtained with the 80% aqueous-ethanolic leaf extract (MIC values of 4.16 Á/8.32 m g/ml against staphylococci and enterococci) and with the 96% ethanolic seed extract (MIC values of 8.32 Á/16.64 m g/ml and/8.32 m g/ml against staphylococci and enterococci, respectively). The results indicate that both fluid extract and tincture have very good antimicrobial efficacy against all strains of multiresistant staphylococci and enterococci. In this study the minimal bactericidal concentration (MBC) values were identical to the MIC values or twofold higher than the corresponding MIC. This may indicate a bactericidal effect. Stored extracts have similar anti-staphylococcal and anti-enterococcal activity to recently obtained extracts. The results obtained might be considered sufficient to warrant further studies aimed at isolation and identification of the active principle.