Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety (original) (raw)
Novel inhibitors of inosine monophosphate dehydrogenase (IMPDH)
Dipesh Risal
2002
View PDFchevron_right
Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity
ganga dhar
Journal of Medicinal Chemistry, 2002
View PDFchevron_right
Novel Inhibitors of Inosine Monophosphate Dehydrogenase in Patent Literature of the Last Decade
Riccardo Petrelli, Loredana Cappellacci
Recent Patents on Anti-Cancer Drug Discovery, 2013
View PDFchevron_right
Cofactor Mimics as Selective Inhibitors of NAD-dependent Inosine Monophospate Dehydrogenase (IMPDH) - the Major Therapeutic Target
Dipesh Risal
Current Medicinal Chemistry, 2004
View PDFchevron_right
Novel inhibitors of IMPDH
Zhongqi Shen
Bioorganic & Medicinal Chemistry Letters, 2003
View PDFchevron_right
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain
Riccardo Petrelli, Krzysztof Pankiewicz
Bioorganic & Medicinal Chemistry, 2011
View PDFchevron_right
3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–Activity relationships
Zhongqi Shen
Bioorganic & Medicinal Chemistry Letters, 2003
View PDFchevron_right
Inhibitors of inosine 5′-monophosphate dehydrogenase as emerging new generation antimicrobial agents
Althaf Shaik
MedChemComm, 2019
View PDFchevron_right
Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors
Riccardo Petrelli, Loredana Cappellacci, Mario Grifantini
Bioorganic & Medicinal Chemistry, 2005
View PDFchevron_right
CONSERVED WATER MIMIC INHIBITOR DESIGN FOR hIMPDH (INOSINE MONOPHOSPHATE DEHYDROGENASE): MD SIMULATION AND DOCKING STUDIES OF IMP-ANALOGS
Subrata Dasgupta
View PDFchevron_right
Crystal structure of human type II inosine monophosphate dehydrogenase: Implications for ligand binding and drug design
Kristen Vanderveen
Proceedings of the National Academy of Sciences, 1999
View PDFchevron_right
Recent Advances on the Enantioselective Synthesis of C-Nucleosides Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH)
Pedro Merino
Current Topics in Medicinal Chemistry, 2014
View PDFchevron_right
Probing Binding Requirements of Type I and Type II Isoforms of Inosine Monophosphate Dehydrogenase with Adenine-Modified Nicotinamide Adenine Dinucleotide Analogues
Daniel Wilson
Journal of Medicinal Chemistry, 2007
View PDFchevron_right
Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3
Zhongqi Shen
Bioorganic & Medicinal Chemistry Letters, 2003
View PDFchevron_right
The Practical Synthesis of a Methylenebisphosphonate Analogue of Benzamide Adenine Dinucleotide: Inhibition of Human Inosine Monophosphate Dehydrogenase (Type I and II) 1
Andrzej Zatorski
Journal of Medicinal Chemistry, 1997
View PDFchevron_right
Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid
Mark Murcko
Cell, 1996
View PDFchevron_right
Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase
Donna Bassolino
Bioorganic & Medicinal Chemistry Letters, 2002
View PDFchevron_right
Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor
Krzysztof Pankiewicz
2007
View PDFchevron_right
Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase
Naoyuki Saito
Journal of Biological Chemistry, 2007
View PDFchevron_right
Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N -(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)
Zhongqi Shen
Journal of Medicinal Chemistry, 2007
View PDFchevron_right
Enterohepatic Recirculation A Powerful Incentive for Drug Discovery in the Inosine Monophosphate Dehydrogenase Field
Mini-Reviews in Medicinal Chemistry MRMC
Bentham Science Publishers
View PDFchevron_right
Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
Elena Matyugina
Acta Naturae, 2012
View PDFchevron_right
Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase
Youngchang Kim
Journal of Medicinal Chemistry, 2013
View PDFchevron_right
Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening
Yeou-guang Tsay
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
View PDFchevron_right
A new efficient synthesis of N-(2-(2-(3-methoxy-4-(oxazol-5-yl)phenylamino)oxazol-5-yl)phenyl)-N-methyl-2-morpholinoacetamide (BMS-337197), A novel IMPDH inhibitor
balu balasubramanian
Arkivoc, 2007
View PDFchevron_right
Triazole-Linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human and Mycobacterium tuberculosis
Daniel Wilson
Journal of Medicinal Chemistry, 2010
View PDFchevron_right
Development and Manufacture of the Inosine Monophosphate Dehydrogenase Inhibitor Merimepodib, VX-497
Adam Looker
Organic Process Research & Development, 2008
View PDFchevron_right
Isosteric Analogues of Nicotinamide Adenine Dinucleotide Derived from Furanfurin, Thiophenfurin, and Selenophenfurin as Mammalian Inosine Monophosphate Dehydrogenase (Type I and II) Inhibitors
Loredana Cappellacci, Mario Grifantini
Journal of Medicinal Chemistry, 1998
View PDFchevron_right
A QSAR model of benzoxazole derivatives as potential inhibitors for inosine 5`-monophosphate dehydrogenase from Cryptosporidium parvum
Surya Dwivedi
Bioinformation, 2016
View PDFchevron_right
The Antibiotic Potential of Prokaryotic IMP Dehydrogenase Inhibitors
George Liechti
Current Medicinal Chemistry, 2011
View PDFchevron_right
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases
Daria Mochly-rosen
2011
View PDFchevron_right
Characterization of Pharmacological Efficacy of VX-148, a New, Potent Immunosuppressive Inosine 5'-Monophosphate Dehydrogenase Inhibitor
Eduardo Leon
Journal of Pharmacology and Experimental Therapeutics, 2002
View PDFchevron_right
Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid
Francisco Talamas
Journal of Medicinal Chemistry, 1996
View PDFchevron_right
Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid 1
David Milan
Journal of Medicinal Chemistry, 1996
View PDFchevron_right
Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues
Zhongqi Shen
Bioorganic & Medicinal Chemistry Letters, 2003
View PDFchevron_right