Combined modulation of polycomb and trithorax genes rejuvenates β cell replication (original) (raw)

Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus

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Danwei Huangfu

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Glucose metabolism: key endogenous regulator of β-cell replication and survival

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Growth and Regeneration of Adult β Cells Does Not Involve Specialized Progenitors

Simon Long

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Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration

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Pancreatic β cell identity requires continual repression of non-β cell programs

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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation

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Experimental models of β-cell regeneration

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Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

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Pancreatic progenitors: The shortest route to restore islet cell mass

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Overexpression of Reg3α increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells

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IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

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The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling

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Determinants of pancreatic β-cell regeneration

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Islet neogenesis: a possible pathway for beta-cell replenishment

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PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16 ink4a

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Growth and regeneration of adult beta cells does not involve specialized progenitors

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Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro

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