Ulcerative Colitis: Experience at a Tertiary Care Center (original) (raw)
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International Journal of Research in Medical Sciences, 2014
Ulcerative colitis is a recurrent chronic inflammatory disease of the intestines with unknown etiology and is associated with Crohn's disease which is categorized in IBD class. This disease is caused by abnormal local immune system response to intestinal flora or may be to some self-antigens in genetically susceptible individuals. Ulcerative colitis is a non-granulomatous disease limited to the colon and with exception in severe cases is limited to the mucosa and submucosa. 1 It is estimated that the number of people with this disease in Iran is near to 10000 people. The incidence of the disease has increased in recent decades. The incidence of Crohn's disease and ulcerative colitis in different geographic regions vary from 0.1 to 11 and 0.5 to 24.5 per 1000 person, respectively. 2 The disease is more common in whites in the United States and there was no sexual preference. The incidence of Colitis in North America is 10-12 per 100000 people, with a peak age incidence of 15-25 years old. 3 The incidence of ulcerative colitis is one in a thousand. The overall shape of the data distribution of ulcerative colitis is as a bi-wavelike in which a second peak occurs in the sixth decade of human life and affects women more than men. Geographical distribution of colitis and colonic diseases in the world is the same with high incidence in United States, Canada, United Kingdom and Scandinavia. High incidence has been seen in northern Europe and America than in southern. 4 The most incidence rate of inflammatory bowel disease is ABSTRACT Background: Ulcerative colitis is one of the inflammatory bowel diseases with unknown etiology. Genetic and environmental factors are thought to be effective in this disease. The aim of this study is to assessment of demographic features and clinical symptoms of ulcerative colitis patients refereed to Emam hospital in Ardabil city. Methods: In this retrospective cross-sectional study, 80 cases of ulcerative colitis referred to Emam hospital in Ardabil city were evaluated during 2004-2011. The diagnosis was confirmed based on clinical features, colonoscopy, and pathology and resulting of other causes. Data were collected through direct interview and analyzed by statistical method in SPSS software. Results: Mean age of patients was 36.4 (SD=18.4). Duration of symptoms onset until diagnosis was 8 months. Male to female ratio was 0.8/1. 38(47.5%) of patients were male and 42 (52.5%) were female. 3 (3.75%) of patients have history of positive UC and 4 (5%) history of appendectomy. According to colonoscopy finding, 1 (1.25%) have rectum involvement, 27 (33.75%) recto sigmoid, 23 (28.75%) left side colon and 4 (5%) have pan colitis. Conclusion: Results showed that in compare with other places, clinical signs of ulcerative colitis in Ardabil province are different and so doing other d epidemiologic studies based on population to determine incidence and prevalence ulcerative colitis in Ardabil province is necessary.
Clinical Presentation of Ulcerative Colitis in Pakistani Adults
Euroasian Journal of Hepato-Gastroenterology, 2015
EJOHG MATERIALS AND METHODS Retrospective data were obtained from the vigilant review of all adult patients with UC who attended a busy gastroenterology outpatient clinic between 2008 and 2012. All patients with age 15 years and above, of either ABSTRACT Objective: The aim of this study was to determine the clinical presentation and severity of ulcerative colitis (UC) in Pakistani adult patients. Materials and methods: An observational study. Data were obtained by reviewing the medical records of patients who visited a gastroenterology clinic between 2008 and 2012. Results: There were 54 patients diagnosed as UC. The male to female ratio was 1:1. Mean age at diagnosis of UC was 38.7 ± 11.8 years (median 36.5, range 18-64). The predominant presenting symptoms were mucus diarrhea in 49 (90.7%), gross blood in stools in 42 (77.8%), abdominal pain or cramps in 40 (74.1%) and weight loss in 15 (27.7%). Leftsided colitis was present in 23 (42.6%), pancolitis in 15 (27.8%), extensive colitis in 11 (20.4%), and proctitis in five (9.2%). The severity of UC as judged by the Mayo scoring system showed that 68.5% were suffering from moderate to severe disease while 31.5% had mild disease. The extra-intestinal manifestation were found only in seven patients; arthritis in five patients and anterior uveitis in two patients. The arthritis was unilateral and the sites were knee joint in three patients and sacroiliac joint in two patients. Conclusion: Ulcerative colitis presents in our adult patients may present at any age with no gender preponderance. The disease severity is moderate to severe in the majority of patients and more than half of them have left-sided colitis or pancolitis at the time of presentation. Extraintestinal manifestations were not common.
TAJ: Journal of Teachers Association
Ulcerative colitis is an idiopathic inflammatory bowel disease characterized by continuous mucosal inflammation that starts in the rectum and extends proximally. Ulcerative colitis is considered frequent in majority of European and North American population and exceptional in most of the developing Asian countries. The present study was designed to estimate the disease severity and colonic involvement of ulcerative colitis in a tertiary care hospital of Rajshahi Medical College. The study population includes of 60 ulcerative colitis patients. Patients were categorized on the basis of disease severity ; moderate : 34, and severe: 26 and involvement of colon: 28 (46.40%) pancolitis, 20 (33.96%) left sided colitis and had 12 (19.61%) proctosigmoiditis.
IOSR Journal of Dental and Medical Sciences, 2017
Ulcerative colitis is a chronic disease of the bowel that results in inflammation and ulceration of the colon and rectum. It presents with loose stools mixed with mucous and blood. The exact etiology is unknown. The factors considered frequently are life style changes, smoking, food habits, sanitation, exposure to infections, occupation, disordered immune response and genetic factors. The incidence in Indians is rising. Considering the varied clinical profile in different geographical distribution, it is worth investigating the clinical profile. Indian studies are few in number.Thisresearch is aimed to study the clinical profile of patients with ulcerative colitis attending a tertiary care hospital in central Kerala. A descriptive study conducted in all consecutive patients having a diagnosis of ulcerative colitis attending the medicine, surgery and gastroenterology department was done. The most common clinical feature was loose stools with blood and mucus, with moderate severity and the duration of ranged from 1 month to 7 years. The mean age of onset of symptoms were 40 yrs. Life style modifications including exercise and stress relieving therapies may help reducing the incidence.
Bangabandhu Sheikh Mujib Medical University Journal, 2016
Background: The prevalence of Ulcerative colitis has been increasingly reported from Western countries as well as other Asian countries. Our personal experience shows that Ulcerative colitis is not uncommon in our country and is being diagnosed more commonly. So, there is need to study the disease pattern in our country. Objective: To find out the clinical presentation, among Bangladeshi population. Methods: A hospital (Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University) based study registering previously diagnosed and newly diagnosed cases of Ulcerative colitis, was carried out from January 1990 to June 2010. Data that were obtained are: age and sex of the patients, clinical presentations like bloody diarrhoea, per rectal bleeding, diarrhoea without per rectal bleeding, urgency, tenesmus, abdominal pain, fever, anorexia, weakness, weight loss. Data regarding physical findings and extra intestinal manifestations were also recorded. Results: Out of 164 patie...
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 2016
Background: The prevalence ulcerative colitis (UC) in RSCM Jakarta in 1991-1995 is 2.5%. The disease affects men and women at similar rates or slightly more common in women than in men. Age of onset follows a bimodal pattern, with a peak at 15-25 years and a smaller one at 55-65 years, although the disease can occur in people of any age. The precise etiology of UC is not well understood. UC is precipitated by a complex in Dr. Saiful Anwar General Hospital Malang. Method: This is a retrospective survey analysis from medical record which was taken from 2170 patients who underwent colonoscopy in Dr. Saiful Anwar General Hospital Malang from January 2010 to December 2014. Demographic setting (sex, age), clinical features, lifestyle, diagnosis based on colonoscopy were analyzed as the variables. Results: Total patients with UC was 176 patients. The prevalence of UC during 2010-2014 was 8.2% at Dr. Saiful Anwar General Hospital. There was a similar prevalence of sex between male and female patients, in which 95 (53.4%) were male and 81 (46.6%) were female. The average age of patients with UC was 41,6 years. Most patients were presented with abdominal pain (32.90%) and weight loss (42.1%). The diagnosis based on colonoscopy were pancolitis (36%), proctosigmoiditis/proctitis (31.81%), and left-sided colitis (21.9%). The risk Majority of ulcerative colitis study samples were non-smoker (75%), not consuming herbal treatment/NSAID diet and UC (r =-0.106, p = 0.000). Conclusion: average age was 41.6 years. Patients presented with various clinical symptoms, most are abdominal pain and
Prevalence of Ulcerative Colitis in Patients Who Underwent Colonoscopy in Benha University Hospitals
Background: Colonoscopy is the most accurate diagnostic tool in IBD. It is useful in detection of the severity and extent of UC. the incidence of IBD especially UC increased significantly among Egyptian patients as evidenced in previous studies in the past ten years. Aim of Study: To study the prevalence of UC among patients referred to the internal medicine endoscopy unit to perform colonoscopy and evaluate the most common presenting symptoms of UC. Patients and Methods: Cross sectional study encompassed 190 patients who underwent colonoscopy during the period from October 2018 to October 2019, the main presenting complaint was recorded and the result of colonoscopy. Results: Prevalence of UC was about 11.05% on the other side, internal hemorrhoids was the commonest diagnosis in group I (Non-UC patients) 26.6% followed by nonspecific colitis in 23.6%. Bleeding per rectum was the main symptom and indication for colonoscopy (50.5%) but was not significantly different among studied groups. Conclusion: Prevalence of UC raised in Egypt in the last years. In this study, it was the 3 rd diagnosis after internal hemorrhoids and non-specific colitis constituting about 11.05%.
The Sigmoidoscopic extent of ulcerative colitis and associated factors in Pakistani population
2021
In this retrospective cohort study, patients who underwent sigmoidoscopy from July 2013 to July 2020 at Liver Clinic, Jail Road, Lahore, were categorized into two cohorts: who had ulcerative colitis confirmed on histology and who had no ulcerative colitis. Extent and severity of the disease as well as coexisting pathologies were also noted. SPSS version 25 was used. Independent sample T-test was applied to compare quantitative variables like age and weight, and chi-square test to compare qualitative variables with two cohorts. The p-value less than 0.05 was opted as significant. Odd ratio with 95% confidence interval (CI) were also computed for each association. Results: About 11.55% patients (165 out of 1428) had ulcerative colitis, whose mean age and mean weight were 38.27 ± 14.15 years and 74.08 ± 13.20 Kg respectively. Among ulcerative colitis patients, 18.2% had proctitis, 22.4% had proctosigmoiditis, 27.7% had left-sided colitis, and 31.5% had extensive colitis. May endoscopic severity score was found 0,1,2, and 3 in 12.1%, 23.6%, 31.5%, and 32.7% patients respectively. Ulcerative colitis cohort had significant association with younger age (p<0.01), female gender (p<0.01), non or former smoking (p=0.02) and presentation with bloody diarrhea (p<0.01), and no association with body weight (p=0.311), presence of diabetes mellitus (p=0.311) and family history of IBD (P=0.368). Conclusion: Endoscopic extent and severity of ulcerative colitis is high in our studied population. Ulcerative colitis is more prevalent in younger age and female gender patients who presented with bloody diarrhea, while the presence of active smoking has negative association with finding the ulcerative colitis. However, presence of family history of IBD, diabetes mellitus and body weight of the patient has no statistical correlation with finding ulcerative colitis during sigmoidoscopic examination in our patients.
Revision of the demographic and clinical data of patients with ulcerative colitis in Turkey
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2017
Aim To evaluate the demographic and clinical data of fifty two patients with the diagnosis of ulcerative colitis. Methods A total of 52 patients diagnosed with ulcerative colitis by clinical, endoscopical and histopathological evaluations were included the study. Demographic data, colon involvement site of the disease and disease severity were examined from the patients' records. The patients were divided into groups according to the Baron grading system. Results Distribution of patients according to the colon involvement site was: 10 (9.2%) rectal, 16 (30.8%) rectosigmoid, 13 (25%) left sided, 10 (19.2%) extensive colitis and 3 (5.8%) pancolitis. According to colon involvement sites and Baron classification the results were: five (9.6 %), two (3.8%) and three (5.7%) patients with ulcerative proctitis were at grade 1, 2 and 3, respectively. Two (3.8%), six (11.5 %), six (11.5 %) and two (3.8%) patients with rectosigmoid ulcerative colitis were at grade 0, 1, 2 and 3, respectivel...
Indian Society of Gastroenterology consensus on ulcerative colitis
2012
In 2012, the Indian Society of Gastroenterology's Task Force on Inflammatory Bowel Diseases undertook an exercise to produce consensus statements on Crohn's disease (CD). This consensus, produced through a modified Delphi process, reflects our current recommendations for the diagnosis and management of CD in India. The consensus statements are intended to serve as a reference point for teaching, clinical practice, and research in India.