Noisomes: as novel vesicular drug delivery system (original) (raw)

Niosomes : as novel vesicular drug delivery system

2018

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Noisome are promising vehicle for drug delivery and being non-ionic, more stable, inexpensive, biodegradable, biocompatible, non immunogenic and exhibit flexibility in their structural characterization. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various c...

Non-Ionic Surfactant Vesicles (Niosomes) as New Drug Delivery Systems

Novel Approaches for Drug Delivery

Lipid vesicular systems composed of hydrated amphihiles with or without bilayer inducing agents such as cholesterol. On the basis of used amphiphilic molecule different nomenclature are used as liposomes, ufasomes and niosomes. Nonionic surfactants with mono-, di- or trialkyl chains form niosomes which are lipid vesicles with more chemical stability in comparison with phospholipids of liposomes. Both hydrophobic and hydrophilic chemicals can be encapsulated in niosomes as a new drug delivery system. This drug carrier system could have administered via injection, oral, pulmonary, vaginal, rectal, ophthalmic, nasal or transdermal routes with penetration enhancing potential. This chapter presents a detailed explain about niosome forming components, methods of preparation and routes of administration. Many examples for drug delivery potential of niosomes are also available in this review. Vaccine adjuvant and genetic substances vector capabilities are not given here.

Niosomes: A Novel Drug Delivery System

Niosome are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Noisome are promising vehicle for drug delivery and being non-ionic; and Niosomes are biodegradable, biocompatible nonimmunogenic and exhibit flexibility in their structural characterization. Niosomes have been widely evaluated for controlled release and targeted delivery for the treatment of cancer, viral infections and other microbial diseases. Niosomes can entrap both hydrophilic and lipophilic drugs and can prolong the circulation of the entrapped drug in body. Encapsulation of drug in vesicular system can be predicted to prolong the existence of drug in the systemic circulation and enhance penetration into target tissue, perhaps reduce toxicity if selective uptake can be achieved. This review article focuses on the advantages, Disadvantages, preparation methods, factors affecting, characterizations, invitro methods, drug release kinetics, and applications of noisome.

Non-ionic surfactant carrier/vesicle drug delivery system

International Journal of Multidisciplinary Research and Growth Evaluation, 2023

Niosomes are one of the prominent Novel Drug Delivery systems. Niosomes are made up of non-ionic surfactants with or without cholesterol. Primarily niosomes are similar to liposomes in terms of physical properties but differ in chemical nature. Due to their higher chemical stability of surfactants than lipids these are unsurpassed when compared with liposomes. As niosomes are amphiphilic they can be utilized as a carrier for both lipophilic, and hydrophilic drugs. The application of niosomes is widely varied and can be used to treat several diseases like cancer, leishmaniasis, Parkinson, Psoriasis disease, etc. This review focuses on all aspects of niosomes including their historical development, structural components, types, formulation techniques, factors affecting their formation, controlling the size, separation of unentrapped materials, characterization, therapeutic potentials, and stability.

Non-ionic surfactant vesicles and their therapeutics potentials

2016

Niosomes are a novel drug delivery system in which drug is encapsulated in vesicles. Niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. Niosomes proved to be a promising drug carrier and has potential to reduce the side effects of drugs and increased therapeutic effectiveness in various diseases. The success of Niosomes as drug carriers has been reflected in a number of surfactant -based formulations, which are commercially available or are currently undergoing clinical trials. This review is mainly focused on the diseases that have attracted most attention with respect to niosome drug delivery. This vesicular drug delivery system having lots of advantage over other type of drug delivery system. Niosomes and liposomes are equiactive in drug delivery potential and both increase drug Efficacy as compared with that of free drug.

Niosomes: A Controlled and Novel Drug Delivery System

Biological & Pharmaceutical Bulletin, 2011

During the past decade formulation of vesicles as a tool to improve drug delivery, has created a lot of interest amongst the scientist working in the area of drug delivery systems. Vesicular system such as liposomes, niosomes, transferosomes, pharmacosomes and ethosomes provide an alternative to improve the drug delivery. Niosomes play an important role owing to their nonionic properties, in such drug delivery system. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant based multilamellar or unilamellar vesicles in which an aqueous solution of solute is entirely enclosed by a membrane resulting from the organization of surfactant macromolecules as bilayer. Niosomes are formed on hydration of non-ionic surfactant film which eventually hydrates imbibing or encapsulating the hydrating aqueous solution. The main aim of development of niosomes is to control the release of drug in a sustained way, modification of distribution profile of drug and for targeting the drug to the specific body site. This paper deals with composition, characterization/evaluation, merits, demerits and applications of niosomes.

Niosome: An Unique Drug Delivery System

Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. This systemic review article deals with preparation methods, characterizations, factors affecting release kinetic, advantages, and applications of niosomes.

A Novel Drug Delivery System: Niosomes Review

Drug targeting is a kind of mechanism in which the drug is administered in the body in such a way that the drug interacts at a cellular or subcellular level with the target tissue to achieve a desired therapeutic response at a desired location without unwanted interactions at other sites. This can be done by modern methods such as niosomes, which target the drug delivery system. Niosomes are the type of non-ionic surfactant vesicles which are a new approach to liposomes that is biodegradable, non-toxic, more durable and cheaper. Their liposome-like structure and therefore they can represent alternate vesicular structures in relation to liposomes. The niosomes appear to load various types of drugs. This review article describes niosome structure, benefits, drawbacks, niosome preparation methods and pharmaceutical NSV characterisation.

Pharmaceutical Niosomes Drug Delivery: A Complete Review of New Delivery System

IJRDO-Journal of Applied Science

Over the past ten years, people working in the field of drug delivery systems have become increasingly interested in designing vesicles as a tool to improve drug delivery. A hydrating mixture of cholesterol and nonionic surfactants forms niosomes, which are vesicles. Liposomes, microspheres, engineering science,small emulsions, antibody loaded drug delivery , magnetic microcapsules,implantable pumps, and niosomes are just a few of the unique methods employed to administer these medications. There are two requirements before designing and developing a novel drug delivery system (NDDS). It must first spread the medication at a preset rate and then release an amount of medication at the site of action that is therapeutically efficacious. These requirements cannot be satisfied by conventional dose forms. In essence, niosomes are non-ionic surfactant-based vesicles in which a group of surfactant macromolecules forms a bilayer to form a membrane that entirely seals off an aqueous solut...

Novel drug delivery system for the vesicular delivery of drug by the niosomes

Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of non-ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. Drug delivery system using colloidal particulate carrier such as liposomes or niosomes has distinct advantages over conventional dosage forms because the particles can act as drug containing reservoirs. Modification of the particle composition or surface can adjust the affinity for the target site and/or the drug release rate. Niosomes proved to be a promising drug carrier and has potential to reduce the side effects of drugs and increased therapeutic effectiveness in various diseases.