Acinar-to-Ductal Metaplasia (ADM): On the Road to Pancreatic Intraepithelial Neoplasia (PanIN) and Pancreatic Cancer
Cécile Haumaitre
International Journal of Molecular Sciences
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Loss of Activating Transcription Factor 3 prevents KRAS-mediated pancreatic cancer
Nawab Azizi
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Recombinant Reg3α protein protects against experimental acute pancreatitis in mice
martin omondi
Molecular and cellular endocrinology, 2015
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A central role for RAF��� MEK��� ERK signaling in the genesis of pancreatic ductal adenocarcinoma
David Dankort
2012
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RPL38, FOSL1, and UPP1 Are Predominantly Expressed in the Pancreatic Ductal Epithelium
Robb Wilentz
Pancreas, 2005
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Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia
Paul Grippo
Scientific reports, 2016
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Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
Pawel K. Mazur
2012
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ERK2-regulated TIMP1 Induces Hyperproliferation of K-RasG12D-Transformed Pancreatic Ductal Cells
Peter Lelkes
Neoplasia, 2013
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Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells
Yaan Kang
Clinical Cancer Research, 2013
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Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
Paul Grippo
Cancer research, 2003
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Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice
Jun-li Liu
AJP: Gastrointestinal and Liver Physiology, 2010
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Ngn3+ endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium
Beatriz Sosa-pineda, Ruth Ashery-Padan
Developmental Biology, 2011
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The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
Michael Lotze
Proceedings of the National Academy of Sciences of the United States of America, 2012
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Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer
Pawel K. Mazur, Roland Schmid
Gastroenterology, 2011
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Amplification, Cloning and Expression of the REG3 Δ Gene from Mouse Pancreas
Tehmina Siddique
2015
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Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
Steven Leach
Proceedings of the National Academy of Sciences, 2008
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Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma
Đức Trịnh
Cancer Science
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The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma
Chính Hoàng
eLife, 2015
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IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation
Gwen Lomberk, Juan Iovanna
Journal of Clinical Investigation, 2014
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Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer
Manuela Baccarini
Cancer Cell, 2013
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REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A–JAK2/STAT3 positive feedback loop
Victor Wang
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Docking protein p130Cas regulates acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
Paola Defilippi
Gastroenterology, 2021
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Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model
Marcel Lee
The American Journal of Pathology, 2016
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Pancreatic reg Gene Expression Is Inhibited During Cellular Differentiation
Riccardo Perfetti
Annals of Surgery, 1997
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Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer
Rolf Brekken
JCI Insight
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Ben Hitt
Cancer Cell, 2004
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Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice
Alberto J. Schuhmacher
Cancer Cell, 2007
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Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α
Bart Vanhaesebroeck
Genes & Development, 2014
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Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
Ingrid Meszoely
Development, 2005
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Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF- B and MMPs
Howard Crawford, Brian Necela
Journal of Experimental Medicine, 2013
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Pancreatic Regenerating Protein (Reg Ⅰ) and Reg Ⅰ Receptor MRNA Are Upregulated In Rat Pancreas After Induction of Acute Pancreatitis
sameer patel
World J …, 2006
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Akt1 signalling supports acinar proliferation and limits acinar‐to‐ductal metaplasia formation upon induction of acute pancreatitis
Theresia Reding Graf
The Journal of Pathology
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PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance
MOHAMEDI BRAHIM
Genes & development, 2016
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In Vivo Lineage Tracing Defines the Role of Acinar-to-Ductal Transdifferentiation in Inflammatory Ductal Metaplasia
Sarah Thayer
Gastroenterology, 2007
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