Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida (original) (raw)
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Evidence-Based Complementary and Alternative Medicine
The edible herb Sterculia foetida L. has potential nutraceutical and medicinal effects. The present study is performed to assess the possible antidiabetic, neuropharmacological, and antidiarrheal activity of the methanolic extract of S. foetida seeds (MESF) through in vitro, in vivo, and in silico approaches. When compared to standard acarbose, the results of the antidiabetic study provided strong proof that the glucose level in the MESF was gradually decreased by inhibiting the function of α-amylase enzymes. The sedative potential of MESF (200 and 400 mg/kg) was determined by employing open field, hole cross, and thiopental sodium-induced sleeping time tests, which revealed significant reductions in locomotor performance and increased sleep duration following MESF treatment. In addition, mice treated with MESF exhibited superior exploration during elevated plus maze and hole board tests. MESF also showed good antidiarrheal activity in castor oil-induced diarrhea and intestinal moti...
The Journal of Animal and Plant Sciences, 2020
Genus Sterculia possess various types of compounds which have therapeutic potential. This study was aimed to explore the anticonvulsant, CNS depressant, analgesic, anti-inflammatory and anti-pyretic activities of Sterculia diversifolia stem bark and leaves extracts in mice. The secondary metabolites in MESD (methanolic extract of Sterculia diversifolia) was characterized by UV, IR, 1 H-NMR, 13 C NMR and 2D-NMR spectra in combination with EI-MS spectrometric techniques. Anticonvulsant and CNS depressant effect of MESD was assessed using strychnine-induced convulsion and phenobarbitone-induced hypnotic protocol. Analgesic activity was performed by acetic acid induced writhing and hot plate test while anti-inflammatory and anti-pyretic activities were assessed by carrageenan induced right hind paw edema and brewer's yeast induced pyrexia. The isolation of compounds with different elucidation techniques (1 H-NMR, 13 C NMR and 2D-NMR spectra in combination with EI-MS spectrometric techniques) led to luteolin, isoquercitrin and ursolic acid. The current study results showed that crude MESD significantly (p < 0.05) delayed the onset, shortened the duration and offered protection against strychnine-induced convulsion. Crude MESD significantly (p < 0.05) prolonged the time of phenobarbitone-induced hypnosis. The analgesic response of crude MESD stem bark was more significant as compare to crude MESD leaves, while crude MESD also showed significant anti-inflammatory and antipyretic activity through dose dependent phenomenon. These significant results might be due to flavonoids (luteolin, isoquercitrin) and triterpenoids (ursolic acid) presence, though the involvement of other biologically active secondary metabolites cannot be overlooked.
Analgesic activity of Sterculia Foetida Linn. Flowers.pdf
Medicinal plants have been used both in the prevention and cure of various diseases since ancient times. Sterculia foetida Linn. is a medicinal plant used traditionally as herbal remedy for alleviating pain and for treating various skin diseases and disorders. The seeds of Sterculia foetida Linn have been reported to have analgesic and anti-inflammatory activity. The present study intended to evaluate analgesic activity of ethanolic extract of Sterculia foetida Linn. flowers. The qualitative phytochemical analysis of flower extracts in ethyl acetate and ethanol revealed the presence of flavonoids, saponins and carbohydrates. Analgesic activity of Sterculia foetida Linn flowers was evaluated using the Hot plate method at three dose levels (100, 300 and 500 mg/kg). Analgesic activity was found to be significant at 500mg/kg when compared with control. Considering the findings of this study Sterculia foetida Linn. flowers can be considered as a potential source of pain relieving herbal drugs.
2018
Crude ethanolic extract of Sterculia villosa Roxb. were investigated to determine different medicinal activity to assure this plant as a new source of lead compounds. Preliminary phytochemical screenings with the crude extract revealed the presence of alkaloids, glycosides, tannins, flavonoids, aldehyde and reducing sugars. Based on phytochemical analysis, we performed in vitro anti-diabetic, antiinflammatory, anti-oxidant, anti-cancer and thrombolytic investigation in our study. In case of antidiabetic study, plant extract showed dose depended significant (p < 0.001) hypoglycemic action at 0.9 mg/ml,1.1mg/ml1.3mg/ml and 1.5mg/ml dose where dinitrosalicylic acid (DNSA) method was adopted to estimate α-amylase inhibition. Stabilization of human red blood cell membrane by hypo tonicity induced membrane lysis was taken as a measure of the anti-inflammatory activity and extract showed maximum 35.99% protection where standard drug diclofenac displayed 47.42% protection in 1000μg/ml do...
Triterpenoids and coumarins from the leaves of Sterculia foetida Linn
Science and Technology Development Journal, 2020
Introduction: Sterculia foetida Linn. is widely distributed in tropical countries. As the continuous study on the hexane and ethyl acetate extracts of Sterculia foetida leaves, the isolation and structural determination of four triterpenoids and two coumarins were addressed. Method: The crude extract was prepared from dried power of Sterculia foetida leaves by maceration method in ethanol. This extract was then separated by liquid-liquid partition with n-hexane, chloroform, and ethyl acetate, respectively, to obtain the corresponding extracts. The hexane and ethyl acetate extracts were applied to multiple silica gel column chromatography to yield six compounds. Their chemical structures were determined by the NMR data analysis as well as the comparison their spectroscopic data and physical properties with those of reported literature. Results: Four triterpenoid compounds, including betulinic acid (1), conyzasaponin G (2), taraxerol (3), and taraxer-14-ene- 1a,3b -diol (4), and two c...
Journal of Ethnopharmacology, 2005
Objective: Mallotus philippensis (Mp) is locally known as kamala and is a large woody multipurpose medicinal tree belonging to the family of Euphorbiaceae. Mp possess a wide variety of activities such as skin problem, bronchitis, antifungal, worm infestation (tapeworm) eye disease, cancer, diabetes, and diarrhea. Hence, the present study was intended to evaluate methanolic fruits extract of Mp for hepatoprotective activities. Methods: The hepatoprotective activity was studied by CCl 4 at the dose of 1 ml/kg of body weight in liquid olive oil in the ratio of 1:1 and ATT (isoniazid − 7.5 mg/kg, rifampicin − 10 mg/kg, and pyrazinamide − 35 mg/kg b.w.) induced models. Acute toxicity study and preliminary phytochemical screening were also studied to evaluate the toxicity. Results: No toxicity profile was observed in rats after oral administration of the methanolic fruits extract at the dose of 2 g/kg body weight. The different dose of 300 mg/kg and 500 mg/kg administered with the extract of Mp. There was a significant (p<0.001) reduction in biochemical parameters with respect to control. Phytochemical screening of the fruits extract revealed the presence of tannins, alkaloids, flavonoids and saponins, and terpenoids. Conclusion: It can be concluded that the hepatoprotective activity elucidated by Mallotus philippensis could be mainly due to the presences of highvalue class of compound like the phenolic group as the major content in the plant.
Qualitative Analysis and Biological Screening of Sterculia Tragacantha Fruit Extract
2020
Utilization of natural materials as an alternative medicine in warding off diseases is increasingly in demand. This study aimed to determine the secondary metabolite content, antioxidant activity, antibacterial activity, fatty acid content and amino acid content of the extract of Sterculia tragacantha fruit. Sample was evaluated for phytochemical content, antioxidant activity, antibacterial activity, fatty acid content and amino acids. The results indicated that the phytochemical compounds of papaya woton fruit simplicia include flavonoid, tannin, hydrolyzable tannin, phenolic, polyphenols and saponin. The extract of methanol has a strong antioxidant activity while that of n-hexane has a potential as antibacterial to Vibrio alginolyticus. The main fatty acids of Sterculia tragacantha fruit extract were methyl palmitate and methyl tricosanoate while the main amino acids were L-Arginine, L-Proline and L-Glutamic acid.
Evaluation of the Anti-Arthritic Effect of Sterculia Tragacantha (LINDL.) Leaf Extract in Rats
American Journal of Pharmacology and Toxicology, 2014
Sterculia tragacantha leaves for years have been used by traditional healers in eastern Nigeria in the treatment of arthritis, edema, gout, whitlow and cold. The aim of this study was to evaluate the folkloric claims of Sterculia tragacantha leaf extract in relieving arthritic conditions. The effects of Sterculia Tragacantha methanol leaf Extract (STEX) on formaldehyde and adjuvant-induced arthritis were studied in rats. Paw thickness, White Blood Cell Count (WBC) count, Packed Cell Volume (PCV), Haemoglobin Concentration (HB), Erythrocyte Sedimentation Rate (ESR), lipid peroxidation, Super Oxide Dismutase (SOD) activity and catalase activity were studied post induction of arthritis. In both formaldehyde and adjuvant-induced arthritis studies, mean paw thickness in animals given 300 mg kg −1 STEX was significantly (p<0.05) lower on days 7 and 14 compared to that of normal saline group. Mean WBC of 100 and 300 mg kg −1 v STEX groups were significantly (p<0.05) lower than that of normal saline group. Mean ESR of normal saline and 100 mg kg −1 STEX groups were significantly (p<0.05) faster than ESR of 300 mg kg −1 group. Mean MDA level of 300 mg kg −1 STEX group was similar to that of non-arthritic group while mean SOD levels of 300 and 100 mg kg −1 STEX groups were significantly (p<0.05) higher than that of normal saline group. Mean catalase level of 100 and 300 mg kg −1 STEX groups were significantly (p<0.05) higher compared to that of normal saline group. These results show that STEX exhibited potent anti-arthritic activity.
Journal of Medicinal Plants Studies, 2021
Stenochlaena palustris is a widely found fern in mangrove forests and other areas of different countries over the world. This plant has many uses in traditional medicine of many countries. This study was conducted on its leaves extract to investigate its different phytochemical and pharmacological properties based on its local medicinal uses. Phytochemical screening indicated the presence of different secondary metabolites in this plant. On silica coated TLC plates, the extract exhibited the presence of different antioxidative compounds. Total phenolic, flavonoid and tannin contents were determined (97 mg GAE/g, 90 mg QE/g and 23 mg GAE/g, respectively). This extract also scavenged DPPH, hydrogen peroxide and superoxide radicals (SC50 = 80, 158 and 236 μg/ml, respectively). It also showed ferric ion reducing capability (RC50 =166 μg/ml). This plant showed significant antihyperglycemic, peripheral analgesic (acetic acid induced), anti-inflammatory (formaldehyde induced) and laxative activities in mice. This plant also showed little cytotoxic activity in brine shrimp lethality bioassay. These results are also compared with respective standard drugs and our findings justified its traditional usage.