Triterpenoids and coumarins from the leaves of Sterculia foetida Linn (original) (raw)
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Sterculia foetida, also known as jangli badam in Bangladesh, is a traditionally used plant that has pharmacological activities. A qualitative phytochemical analysis was performed to assess the metabolites in a methanolic extract of S. foetida seeds (MESF), and the cytotoxic, thrombolytic, anti-arthritics, analgesic, and antipyretic activities were examined using in vitro, in vivo, and in silico experiments. Quantitative studies were performed through gas chromatography-mass spectroscopy (GC-MS) analysis. The brine shrimp lethality bioassays and clot lysis were performed to investigate the cytotoxic and thrombolytic activities, respectively. The anti-arthritics activity was assessed using the albumin denaturation assay. Analgesic activity was determined using the acetic acid-induced writhing test and the formalin-induced paw-licking test. A molecular docking study was performed, and an online tool was used to perform ADME/T (absorption, distribution, metabolism, and excretion/toxicit...
Pharmacognosy Journal, 2018
Sterculia macrophylla Vent (Hildegardia macrophylla (Vent.) Schott and Endl.) was present in Sumatra, Maluku, and Papua. Sterculia parkinsonii F.Muell was found in Papua, Sterculia rubiginosa Zoll. ex Miq. was in Sumatra. Sterculia stipulate Korth. (Clompanus stipulate Kuntze) was found in Borneo. Sterculia spectabilis (Welw.) Robert / Sterculia spectabilis Miq. (Heritiera spectabilis Baill) found in Sumatra. 1 The genus Sterculia contains flavonoid compounds and their derivatives, terpenoids mostly as triterpenoids, coumarins, alkaloids and other compounds such as phenolic acids, phenyl propanoids, fatty acids, sugars and some steroids. 2 From the literature study obtained data that the main product of secondary metabolites in the genus of sterculia was flavonoids. Sterculia rubiginosa
The Journal of Animal and Plant Sciences, 2020
Genus Sterculia possess various types of compounds which have therapeutic potential. This study was aimed to explore the anticonvulsant, CNS depressant, analgesic, anti-inflammatory and anti-pyretic activities of Sterculia diversifolia stem bark and leaves extracts in mice. The secondary metabolites in MESD (methanolic extract of Sterculia diversifolia) was characterized by UV, IR, 1 H-NMR, 13 C NMR and 2D-NMR spectra in combination with EI-MS spectrometric techniques. Anticonvulsant and CNS depressant effect of MESD was assessed using strychnine-induced convulsion and phenobarbitone-induced hypnotic protocol. Analgesic activity was performed by acetic acid induced writhing and hot plate test while anti-inflammatory and anti-pyretic activities were assessed by carrageenan induced right hind paw edema and brewer's yeast induced pyrexia. The isolation of compounds with different elucidation techniques (1 H-NMR, 13 C NMR and 2D-NMR spectra in combination with EI-MS spectrometric techniques) led to luteolin, isoquercitrin and ursolic acid. The current study results showed that crude MESD significantly (p < 0.05) delayed the onset, shortened the duration and offered protection against strychnine-induced convulsion. Crude MESD significantly (p < 0.05) prolonged the time of phenobarbitone-induced hypnosis. The analgesic response of crude MESD stem bark was more significant as compare to crude MESD leaves, while crude MESD also showed significant anti-inflammatory and antipyretic activity through dose dependent phenomenon. These significant results might be due to flavonoids (luteolin, isoquercitrin) and triterpenoids (ursolic acid) presence, though the involvement of other biologically active secondary metabolites cannot be overlooked.
Chemical constituent with cytotoxicity from Sterculia diversifolia
Journal of Asian Natural Products Research, 2020
One new coumarin (stercularin), along with eleven known compounds, was isolated for the first time from ethyl acetate fraction of Sterculia diversifolia. The structures of isolated compounds were characterized by spectroscopic techniques such as EIMS, 1 H-NMR and 13 C-NMR. Compound 1 showed significant cytotoxicity by brine shrimp lethality assay (LD 50 : 8.00 lg/ml) and PC-3 cell lines protocol (IC 50 : 3.92 ± 0.20 lg/ml), respectively.
International Journal of Research in Ayurveda & Pharmacy, 2015
The objective of this study was to select and identify the sample and to perform extraction of Sterculia lychnophora and to check the presence of phytochemicals by preliminary test along with HPTLC method to be used for qualitative analysis. In present investigation primary screening of phytochemical and qualitative analysis of secondary metabolites like tannins, saponins, phenols, terpenoids, flavonoids, alkaloids and lipids were carried out by HPTLC method. Higher percentage of lipid, tannins and phenol, moderate of flavonoids, saponins and terpenoids while fewer peaks of alkaloids were observed. The present work signifies the use of HPTLC fingerprint for determining the identity, purity of drugs and also for developing standards
Journal of Ethnopharmacology, 2005
Objective: Mallotus philippensis (Mp) is locally known as kamala and is a large woody multipurpose medicinal tree belonging to the family of Euphorbiaceae. Mp possess a wide variety of activities such as skin problem, bronchitis, antifungal, worm infestation (tapeworm) eye disease, cancer, diabetes, and diarrhea. Hence, the present study was intended to evaluate methanolic fruits extract of Mp for hepatoprotective activities. Methods: The hepatoprotective activity was studied by CCl 4 at the dose of 1 ml/kg of body weight in liquid olive oil in the ratio of 1:1 and ATT (isoniazid − 7.5 mg/kg, rifampicin − 10 mg/kg, and pyrazinamide − 35 mg/kg b.w.) induced models. Acute toxicity study and preliminary phytochemical screening were also studied to evaluate the toxicity. Results: No toxicity profile was observed in rats after oral administration of the methanolic fruits extract at the dose of 2 g/kg body weight. The different dose of 300 mg/kg and 500 mg/kg administered with the extract of Mp. There was a significant (p<0.001) reduction in biochemical parameters with respect to control. Phytochemical screening of the fruits extract revealed the presence of tannins, alkaloids, flavonoids and saponins, and terpenoids. Conclusion: It can be concluded that the hepatoprotective activity elucidated by Mallotus philippensis could be mainly due to the presences of highvalue class of compound like the phenolic group as the major content in the plant.
Qualitative Analysis and Biological Screening of Sterculia Tragacantha Fruit Extract
2020
Utilization of natural materials as an alternative medicine in warding off diseases is increasingly in demand. This study aimed to determine the secondary metabolite content, antioxidant activity, antibacterial activity, fatty acid content and amino acid content of the extract of Sterculia tragacantha fruit. Sample was evaluated for phytochemical content, antioxidant activity, antibacterial activity, fatty acid content and amino acids. The results indicated that the phytochemical compounds of papaya woton fruit simplicia include flavonoid, tannin, hydrolyzable tannin, phenolic, polyphenols and saponin. The extract of methanol has a strong antioxidant activity while that of n-hexane has a potential as antibacterial to Vibrio alginolyticus. The main fatty acids of Sterculia tragacantha fruit extract were methyl palmitate and methyl tricosanoate while the main amino acids were L-Arginine, L-Proline and L-Glutamic acid.
Pharmacological activity investigation of Sterculia coccinea Nuzhat Mahbub
2019
Sterculia coccinea plant extract used to assess its different biological activity. Extract was made by soaking the dried plant powder in methanol. After comparing with the standard we found that Methanol extract of the sample gave the activity against all the experimented microbes of ZI (zone of inhibition) against E. coli and B. subtillis. After performing the antioxidant, thrombolytic, antidiarrheal, hypoglycemic and cytotoxic activity assay of methanol extract of sample plant we saw that it has a good biological activity that can be used as a potential traditional medicine.
Analgesic activity of Sterculia Foetida Linn. Flowers.pdf
Medicinal plants have been used both in the prevention and cure of various diseases since ancient times. Sterculia foetida Linn. is a medicinal plant used traditionally as herbal remedy for alleviating pain and for treating various skin diseases and disorders. The seeds of Sterculia foetida Linn have been reported to have analgesic and anti-inflammatory activity. The present study intended to evaluate analgesic activity of ethanolic extract of Sterculia foetida Linn. flowers. The qualitative phytochemical analysis of flower extracts in ethyl acetate and ethanol revealed the presence of flavonoids, saponins and carbohydrates. Analgesic activity of Sterculia foetida Linn flowers was evaluated using the Hot plate method at three dose levels (100, 300 and 500 mg/kg). Analgesic activity was found to be significant at 500mg/kg when compared with control. Considering the findings of this study Sterculia foetida Linn. flowers can be considered as a potential source of pain relieving herbal drugs.