Guidelines ) 1 Extraction and Characterization of Polar Terpenic Constituents from Artemisia maritima (original) (raw)
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Terpenoids from the seeds of Artemisia annua
Phytochemistry, 2003
Fourteen sesquiterpenes, three monoterpenes and one diterpene natural product have been isolated from the seeds of Artemisia annua. The possible biogenesis of some of these natural products are discussed by reference to recently reported experimental results for the autoxidation of dihydroartemisinic acid and other terpenoids from Artemisia annua. #
Journal of Pharmacognosy and Phytochemistry, 2019
Objective: Nowadays a lot of herbal formulations are widely being used in Ayurveda. However, it is not easy to analyse their pharmacological activity unless a phytochemical investigation is conducted of that particular plant extract. Artemisia nilagirica (Clarke) Pamp, a herb belonging to family Asteraceae is reported for its mosquito larvicidal and insect repellent activities. The present study was undertaken to characterize the ethanolic extract, hexane fraction and terpenoid fraction of Artemisia nilagirica using chromatographic techniques. Results: The prepared ethanolic extracts and its fractions were subjected to phytochemical screening which showed presence of terpenoids, flavonoids, saponins, tannins, fixed oils and fats and steroids. HPTLC was used as a tool to detect the presence of polyvalent compounds present in the ethanolic extract and its fractions. The chromatogram showed presence of polyvalent compounds in ethanolic extract and hexane fraction which depicted varied ...
Asian Journal of Pharmaceutical and Clinical Research
Objective: In the present study, the extracts (petroleum ether and methanolic extract) of plant Artemisia maritima were subjected to bioactivity evaluation and compound isolation and characterization.Methods: Antioxidant activity was carried out using ferric reducing power and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The anticancer activity was evaluated by MTT assay using three different human cancer cell lines: Embryonic kidney cancer cell (HEK), lung adenocarcinoma epithelial cell (A-549), and human colon cancer cell (HCT), and isolated compounds were characterized using nuclear magnetic resonance (1HNMR), 13CNMR, DEPT, infrared, and mass spectroscopic techniques.Results: The petroleum ether extract of the plant displayed significant antioxidant and cytotoxic effects, which on phytochemical analysis led to the isolation of two bioactive sesquiterpene lactone compounds. These phytochemicals were identified using different spectral techniques in the light of literature. All the ...
Terpenoids from Artemisia annua and constituents of its essential oil
Phytochemistry, 1994
The hexane extract of the aerial part of Artemisia annua yielded three new cadinanes along with several known compounds of which five have been isolated for the first time from this plant. The essential oil of its aerial part afforded artemisia ketone, cineole and camphor as major components together with several minor components. Structures were elucidated by spectroscopic and chemical transformation methods. INTRODUmION We have recently reported the crystal structure of artemisinic acid (1) [l] and the structure of novel bisnorcadinanes (2,3) [2] from the hexane extract of the aerial part of Artemisia annua. We now describe the identification of other compounds from this plant together with the detailed chemical investigation of the essential oil. CIMAP approval number 93-675. *Author to whom correspondence should be addressed. RESULTS AND DISCUSSION Column chromatographic separations of the hexane extract of the aerial part of A. annua yielded l-6, aamyrenone, a-amyrin, fl-amyrin, taraxasterone, oleanolic acid, stigmasterol, sitosterol, and baurenol. a-Amyrenone, /3-amyrin, baurenol, taraxasterone and oleanolic acid are reported for the first time from A. annua. Compounds 4-6 were new cadinanes and their structure elucidation was carried out mainly by spectroscopic methods. The IR spectrum of 4 showed bands at 3500 and 17OOcm-' for hydroxyl and carbonyl groups, respect-4, R=COCHM% 5 R'=H
Qualitative and quantitative phytochemical analysis of Artemisia indica Willd
2015
Plants have been used for food and also for medicin al purposes since antiquity. Medicinal plants are N ature’s gift to help pursue a disease-free healthy life, and thu s can play an important role in preserving health. In India, Artemisia indica Willd. (Asteraceae) vernacularly k nown as ‘‘Titepati’’ is a perennial herb found in t he western Himalayas and is one of the most utilized locally a s a traditional medicinal plants, especially in the Kumaun hills, though, surprisingly, is also one of the lesser stu died one, with meager information available on its phytochemical analysis. The powdered aerial parts were extracted with methanol (AME), ethanol (AEE) and hydro-methan ol (AHME).The AHME gave the highest yield (20.29%), fo llowed by AME (13.27%) and AEE (7.08%).Out of the t otal of 11 phytocomponents targeted, carbohydrates, redu cing sugars, flavonoids, sterols, tri-terpenoids, p henolics and glycosides were detected in all three extracts. Sap onins and tannins were absent in ...
Molecules, 2021
Diverse medicinal plants such as those from the genus Artemisia have been employed globally for centuries by individuals belonging to different cultures. Universally, Artemisia species have been used to remedy various maladies that range from simple fevers to malaria. A survey conducted by the World Health Organization (WHO) demonstrated that 80% of the global population is highly reliant on herbal medicine for their primary healthcare. WHO recommends artemisinin-based combination therapies (ACT) for the treatment of global diseases such as malaria. Artemisinin is a bioactive compound derived from Artemisia annua leaves. It is a sesquiterpene endoperoxide with potent antimalarial properties. This review strives to instill natural products to chemists and others in diverse fields with a heterogeneous set of knowledge compiled from multifaceted researchers and organizations in literature. In particular, the various Artemisia species and effective extraction, isolation, and characteriz...
Journal of Glycomics & Lipidomics
Artemisia, being the largest and widely distributed genus of the plant family Asteraceae encompasses more than 400 species. Some popular species are reported to possess several medicinal properties owing to the rich phytochemical diversity. Altogether, eight thirty-nine chemical constituents including volatile and non-volatile compounds in these species are listed together with their references. These have been categorized into phenylpropanoids, flavonoids, terpenes, sterols, lignans, phenolics, fatty acids, fatty esters hydrocarbons and miscellaneous compounds, many of which are responsible for various biological activities such as analgesic, anti-parasitic, anti-inflammatory, hypolipidemic, antinociceptive, anti-microbial, anti-oxidant, hepato-protective, antiulcerogenic, anti-malarial, anti-leishmanial, anti-cancer, anti-tumor, anti-diabetic, anticonvulsant, anti-promastigote, anti-convulsant, anxiolytic and anti-depressant. The traditional uses and recent advances in the field of phytochemistry of selected Artemisia species and their respective medicinal, insecticidal and nutritional properties, for the period up to 2017, are assessed and compiled in this paper. Meticulous phytochemical and pharmacological studies on Artemisia species and their sustainable conservation will yield reliable molecules of pharmacological importance, for better healthcare.
Phytochemical Contents of Five Artemisia Species
Notulae Scientia Biologicae
In the present study, the fatty acid compositions, vitamin, sterol contents and flavonoid constituents of five Turkish Artemisia species (A. armeniaca, A. incana , A. tournefortiana, A. haussknechtii and A. scoparia) were determined by GC and HPLC techniques. The results of the fatty acid analysis showed that Artemisia species possess high saturated fatty acid compositions. On the other hand, the studied Artemisia species were found to have low vitamin and sterol contents. Eight flavononids (catechin, naringin, rutin, myricetin, morin, naringenin, quercetin, kaempferol) were determined in the present study. It was found that Artemisia species contained high levels of flavonoids. Morin (45.35 ± 0.65 – 1406.79 ± 4.12 μg/g) and naringenin (15.32 ± 0.46 – 191.18 ± 1.22 μg/g) were identified in all five species. Naringin (268.13 ± 1.52 – 226.43 ± 1.17 μg/g) and kaempferol (21.74 ± 0.65 – 262.19 ± 1.38 μg/g) contents were noted in the present study. Present research showed that the studie...
Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles
Oxidative Medicine and Cellular Longevity
Artemisia plants are traditional and ethnopharmacologically used to treat several diseases and in addition in food, spices, and beverages. The genus is widely distributed in all continents except the Antarctica, and traditional medicine has been used as antimalarial, antioxidant, anticancer, antinociceptive, anti-inflammatory, and antiviral agents. This review is aimed at systematizing scientific data on the geographical distribution, chemical composition, and pharmacological and toxicological profiles of the Artemisia genus. Data from the literature on Artemisia plants were taken using electronic databases such as PubMed/MEDLINE, Scopus, and Web of Science. Selected papers for this updated study included data about phytochemicals, preclinical pharmacological experimental studies with molecular mechanisms included, clinical studies, and toxicological and safety data. In addition, ancient texts and books were consulted. The essential oils and phytochemicals of the Artemisia genus hav...